ID S7QHN0_GLOTA Unreviewed; 838 AA.
AC S7QHN0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=GLOTRDRAFT_57811 {ECO:0000313|EMBL:EPQ58682.1};
OS Gloeophyllum trabeum (strain ATCC 11539 / FP-39264 / Madison 617) (Brown
OS rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Gloeophyllales; Gloeophyllaceae; Gloeophyllum.
OX NCBI_TaxID=670483 {ECO:0000313|EMBL:EPQ58682.1, ECO:0000313|Proteomes:UP000030669};
RN [1] {ECO:0000313|EMBL:EPQ58682.1, ECO:0000313|Proteomes:UP000030669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11539 {ECO:0000313|EMBL:EPQ58682.1,
RC ECO:0000313|Proteomes:UP000030669};
RX PubMed=22745431; DOI=10.1126/science.1221748;
RA Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT 31 fungal genomes.";
RL Science 336:1715-1719(2012).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR EMBL; KB469298; EPQ58682.1; -; Genomic_DNA.
DR RefSeq; XP_007863166.1; XM_007864975.1.
DR AlphaFoldDB; S7QHN0; -.
DR STRING; 670483.S7QHN0; -.
DR GeneID; 19307199; -.
DR KEGG; gtr:GLOTRDRAFT_57811; -.
DR eggNOG; KOG2189; Eukaryota.
DR HOGENOM; CLU_005230_0_0_1; -.
DR OMA; FYLWFFL; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000030669; Unassembled WGS sequence.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000030669};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 415..448
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 460..483
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 545..562
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 583..602
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 639..659
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 774..798
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 105..139
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 838 AA; 95033 MW; DF8162551420E237 CRC64;
MSDDYPTLFR SEPMSLVQLF IPTEVAHDAV AELGELGNVE FKDLNPEVNP FQRSFVGEIR
RVDEMARRVR FFTSQIEKEK DVVPIRPLYD SAPLITVGPR AATTIDELDV TLAEHESRLN
QMNESYQTLS DRMKELVEAR YVLRETAVFF DKAQAQESDV RTSIDESSAP LLQHAERDNQ
FSTATVQFDL EFVAGTIERT RLPTFERVLW RVLRGNLYMN YTDIPEPFVD PVTGAETRKN
VFIIFAHGET LLAKIRKVAE SMGGTLYPID ANADKRADSL REVTARLEDL QTVLYNTGLN
RRSELVRIGE SLASWQDVVA KEKLIYQTLN LFNYDVRRKT LIAEGWCPTR DITTIQLALR
HATEESGTNV PPILHEIRTH KMPPTFMRTN KFTEGFQTIM DSYGIATYQE VNPGLFAVIT
FPFLFAVMFG DIGHGFITFT TALLMITFER KLAKADLGEI IGTFFYGRYI ILLMGAFSMY
TGLLYNDIFS RSLHIWHSGW DWPATPSNDS VAATFNGNVY PFGLDPGWHG AENGLVYTNS
YKMKMSIVLG VIHMTFALCL QVPNHIRFKR FSDIYSNFIP QMIFLQSIFG YLVICILYKW
SIDWSTSPTA PPSLLNMLIG MFLTPGSVDP STQLYRGQGF IQTVLLLLAF VCVPWLLCMK
PYLQYQEMKK IQGQGYVGIP HGDEPPRASS DDVLEGEEEG NGRAIAEDAE EEHEQHDFSE
VVVHQVIHTI EFCLGCISHT ASYLRLWALS LAHAQLSEVL WNMTLGPALG MSGLFGWIAL
AIVFCLWFVL TIFILCVMEG LSAFLHALRL HWVEANSKHY EAGGRQFMPL SFAHLNEA
//
