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Database: UniProt
Entry: S7RHB1_GLOTA
LinkDB: S7RHB1_GLOTA
Original site: S7RHB1_GLOTA 
ID   S7RHB1_GLOTA            Unreviewed;       431 AA.
AC   S7RHB1;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Delta-12 fatty acid desaturase protein {ECO:0000313|EMBL:EPQ51964.1};
GN   ORFNames=GLOTRDRAFT_48373 {ECO:0000313|EMBL:EPQ51964.1};
OS   Gloeophyllum trabeum (strain ATCC 11539 / FP-39264 / Madison 617) (Brown
OS   rot fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Gloeophyllales; Gloeophyllaceae; Gloeophyllum.
OX   NCBI_TaxID=670483 {ECO:0000313|EMBL:EPQ51964.1, ECO:0000313|Proteomes:UP000030669};
RN   [1] {ECO:0000313|EMBL:EPQ51964.1, ECO:0000313|Proteomes:UP000030669}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11539 {ECO:0000313|EMBL:EPQ51964.1,
RC   ECO:0000313|Proteomes:UP000030669};
RX   PubMed=22745431; DOI=10.1126/science.1221748;
RA   Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA   Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA   Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA   Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA   Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA   Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA   Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA   Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA   Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA   Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA   Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA   Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA   Hibbett D.S.;
RT   "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT   31 fungal genomes.";
RL   Science 336:1715-1719(2012).
CC   -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC   -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
CC       {ECO:0000256|ARBA:ARBA00009295}.
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DR   EMBL; KB469309; EPQ51964.1; -; Genomic_DNA.
DR   RefSeq; XP_007869600.1; XM_007871409.1.
DR   AlphaFoldDB; S7RHB1; -.
DR   GeneID; 19306568; -.
DR   KEGG; gtr:GLOTRDRAFT_48373; -.
DR   eggNOG; ENOG502QQNB; Eukaryota.
DR   HOGENOM; CLU_033094_0_0_1; -.
DR   OMA; KSTHRRH; -.
DR   OrthoDB; 4215at2759; -.
DR   Proteomes; UP000030669; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016717; F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   CDD; cd03507; Delta12-FADS-like; 1.
DR   InterPro; IPR005804; FA_desaturase_dom.
DR   InterPro; IPR021863; FAS_N.
DR   InterPro; IPR012171; Fatty_acid_desaturase.
DR   PANTHER; PTHR32100:SF35; DELTA(12) FATTY ACID DESATURASE FAT-2; 1.
DR   PANTHER; PTHR32100; OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC; 1.
DR   Pfam; PF11960; DUF3474; 1.
DR   Pfam; PF00487; FA_desaturase; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030669};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        44..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        85..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        245..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          7..53
FT                   /note="Fatty acid desaturase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF11960"
FT   DOMAIN          90..366
FT                   /note="Fatty acid desaturase"
FT                   /evidence="ECO:0000259|Pfam:PF00487"
SQ   SEQUENCE   431 AA;  50208 MW;  3E9F79264EB6971F CRC64;
     MGIFQNGLEY ERRKITDFAP PKVTLAEIHA AVPKHLFQKS TRKALVYVAR DVFFAALFYY
     AATYIDPACR ALDTRYEGHH RAFVLLRWTL WSVYWFWQGV AFAGWWCLGH EAGHGTMSPH
     SWVNHLLGFT LHTAILVPYY SWRSTHHAHH KATGSMERDE NWVPRTRTDY QLPPEGTAHV
     LDYHDIFEET PIYTLVRIVF QQILGWHAYL TYNALGNKML YPEGFQTNHF IPSSPLFKSH
     ERRDVIISDI GLLAMIGILY YYGTQVGLVN FIKFYFIPYL LANHWIVMLT FLHHSDPTIP
     HYRGKEWSFL RGAVATVDRP LLGWIGRFFL HNVSHDHVAH HFFSIIPFYN QPEVTERIKE
     VLKDDYNYDS TNTFYALYRS FSECCFIEDE GEIVFYKNKD GVAQRHLANN AIGSDSGYSS
     SENEGSDKKK D
//
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