ID S7RKM8_GLOTA Unreviewed; 728 AA.
AC S7RKM8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Acid protease {ECO:0000313|EMBL:EPQ54930.1};
GN ORFNames=GLOTRDRAFT_62321 {ECO:0000313|EMBL:EPQ54930.1};
OS Gloeophyllum trabeum (strain ATCC 11539 / FP-39264 / Madison 617) (Brown
OS rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Gloeophyllales; Gloeophyllaceae; Gloeophyllum.
OX NCBI_TaxID=670483 {ECO:0000313|EMBL:EPQ54930.1, ECO:0000313|Proteomes:UP000030669};
RN [1] {ECO:0000313|EMBL:EPQ54930.1, ECO:0000313|Proteomes:UP000030669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11539 {ECO:0000313|EMBL:EPQ54930.1,
RC ECO:0000313|Proteomes:UP000030669};
RX PubMed=22745431; DOI=10.1126/science.1221748;
RA Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT 31 fungal genomes.";
RL Science 336:1715-1719(2012).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447}.
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DR EMBL; KB469303; EPQ54930.1; -; Genomic_DNA.
DR RefSeq; XP_007867146.1; XM_007868955.1.
DR AlphaFoldDB; S7RKM8; -.
DR GeneID; 19307470; -.
DR KEGG; gtr:GLOTRDRAFT_62321; -.
DR eggNOG; KOG1339; Eukaryota.
DR HOGENOM; CLU_014988_0_0_1; -.
DR OMA; SSPMYDI; -.
DR OrthoDB; 1449676at2759; -.
DR Proteomes; UP000030669; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd05471; pepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR034164; Pepsin-like_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF92; PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00026; Asp; 2.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:EPQ54930.1};
KW Membrane {ECO:0000256|SAM:Phobius}; Protease {ECO:0000313|EMBL:EPQ54930.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030669};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 465..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 54..399
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT REGION 600..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..625
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..728
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 728 AA; 76924 MW; 61EA0B8E639ADA17 CRC64;
MSARAGIPLR RWKGKGREVL LESRSASTTE GNGGNDGVVM PMQMTGDGTY NVEYTVPITV
GNGQTLSVQV DTGSSDLWLA STSCSSSACS STNGRLYNPG QALPTGQTFN INYLIGNVSG
PIVWDEVQLG GYSITNQALA AASKVDGEPL SQNFDGVLGL ALPGNSIIQA AIMPTLGDSP
DGAAFSSNLF GITPVSQAPP VRFLSLSLER PGSDRTPSLL GIGRHPSQVA PDPSKIAYST
LLASSSAGVR FWETSIRAIT VYVDGGAKAV SLGHSHTGAV YPIAVVDSGV PYIITTSAIA
NGIYGAIGIN PAANGQYYVP CSTPLNMTIS LDGQPELPLH PLDLTAVPLQ DASSPNCIGL
IQAADGALAN IPGDMILGVP FLRNVYTVLA YDVPDSNGAF PQVSASTTAN SINPRLGLLS
LTNATTALDE FHTVRVLNQP LSKTPKTSDT NGVAGKKGLS VGLDVLIGLL SFFGLCAVLF
GLRWVLAKRQ WRRSHPRGEE GQLDAKDSGY ALAALHPNGD GPSEETLRTL RYEAYKRNKR
MHSEYSTDSA LTKVDVDERE DSGYLPDHEL GFRPSFYDKG RHDPHASIAT DWRDTLVGEA
DSAGTPRAKD ESPSPEMHRR HLSDPEAPVT APLLAHARTH SQTSQGSDVG QAGDRVSMAG
IGSASRGSRH LEHGLRDSVG SFGSFHDVDG SGNRVYAPSP LRPHPTHAPD RPRSPLEDRG
GARPEYEP
//
