ID S7RND1_GLOTA Unreviewed; 499 AA.
AC S7RND1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Acid protease {ECO:0000313|EMBL:EPQ54274.1};
GN ORFNames=GLOTRDRAFT_62809 {ECO:0000313|EMBL:EPQ54274.1};
OS Gloeophyllum trabeum (strain ATCC 11539 / FP-39264 / Madison 617) (Brown
OS rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Gloeophyllales; Gloeophyllaceae; Gloeophyllum.
OX NCBI_TaxID=670483 {ECO:0000313|EMBL:EPQ54274.1, ECO:0000313|Proteomes:UP000030669};
RN [1] {ECO:0000313|EMBL:EPQ54274.1, ECO:0000313|Proteomes:UP000030669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11539 {ECO:0000313|EMBL:EPQ54274.1,
RC ECO:0000313|Proteomes:UP000030669};
RX PubMed=22745431; DOI=10.1126/science.1221748;
RA Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT 31 fungal genomes.";
RL Science 336:1715-1719(2012).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; KB469304; EPQ54274.1; -; Genomic_DNA.
DR RefSeq; XP_007867573.1; XM_007869382.1.
DR AlphaFoldDB; S7RND1; -.
DR GeneID; 19307506; -.
DR KEGG; gtr:GLOTRDRAFT_62809; -.
DR eggNOG; KOG1339; Eukaryota.
DR HOGENOM; CLU_013253_1_1_1; -.
DR OMA; ITIWMEL; -.
DR OrthoDB; 4946at2759; -.
DR Proteomes; UP000030669; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd05471; pepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR034164; Pepsin-like_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF51; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750,
KW ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454, ECO:0000313|EMBL:EPQ54274.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030669};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..499
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004544597"
FT DOMAIN 179..496
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 197
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 387
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 210..218
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 499 AA; 52762 MW; 8FC999C6164A1C53 CRC64;
MKVNMNFSGL LAAVVLAVSL GTPSDARPAP SGSGLVTVPI TRIHKTSHRD IIDTQAIHLQ
HVNRGNQRLA LMSGRPAPTP EELQEIHRRT GELPADLSKR YWREGVVKWL EDLKTQMKGA
GSAMSKVESF MDTDGSGSSS GGFNPMDLDA ANENTLTPAN APSYDHSLGL DISANDIGYL
ATIQIGTPPR DFKVLVDSGS SDLWVGAENC AANGGGSCGN HTFIGSSSST SFNDTQKTWA
ITYGSGFLSG TIAQDDIEIA GMKLPAHQFG AAQNESSQFT GSDTLFDGIM GLGGSQLSNQ
GIPTIVEALH SAGLIQAPVT SYKLARLADG NNDGEITFGG MDPAKFDASS KVTVKNVSPK
GYWEANVDSF KVDGKDVNLS GRTAILDTGT TLIVGPGLDV DALHEAMPVS RFDGFNWIIP
CTTTTKVSLT FSGKEFEIDS RDLTFLPVSS TNLTGDCYSS ITRGTVGGDQ EWLVGDVFLK
NVYFSTDVGS NEISLASLA
//
