ID S7VWQ1_9FLAO Unreviewed; 803 AA.
AC S7VWQ1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit {ECO:0000313|EMBL:EPR74546.1};
DE EC=1.2.4.4 {ECO:0000313|EMBL:EPR74546.1};
GN ORFNames=ADIWIN_0446 {ECO:0000313|EMBL:EPR74546.1};
OS Winogradskyella psychrotolerans RS-3.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Winogradskyella.
OX NCBI_TaxID=641526 {ECO:0000313|EMBL:EPR74546.1, ECO:0000313|Proteomes:UP000014962};
RN [1] {ECO:0000313|EMBL:EPR74546.1, ECO:0000313|Proteomes:UP000014962}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS-3 {ECO:0000313|EMBL:EPR74546.1,
RC ECO:0000313|Proteomes:UP000014962};
RX PubMed=23950132;
RA Kumar Pinnaka A., Ara S., Singh A., Shivaji S.;
RT "Draft Genome Sequence of Winogradskyella psychrotolerans RS-3T, Isolated
RT from the Marine Transect of Kongsfjorden, Ny-Alesund, Svalbard, Arctic
RT Ocean.";
RL Genome Announc. 1:e00630-e00613(2013).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPR74546.1}.
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DR EMBL; ATMR01000030; EPR74546.1; -; Genomic_DNA.
DR RefSeq; WP_020896919.1; NZ_ATMR01000030.1.
DR AlphaFoldDB; S7VWQ1; -.
DR STRING; 641526.ADIWIN_0446; -.
DR PATRIC; fig|641526.4.peg.443; -.
DR eggNOG; COG0022; Bacteria.
DR eggNOG; COG1071; Bacteria.
DR OrthoDB; 9769337at2; -.
DR Proteomes; UP000014962; Unassembled WGS sequence.
DR GO; GO:0003863; F:3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity; IEA:UniProtKB-EC.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR033248; Transketolase_C.
DR PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR Pfam; PF00676; E1_dh; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EPR74546.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000014962}.
FT DOMAIN 469..643
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 803 AA; 90183 MW; 8C4C4045ADE47156 CRC64;
MKTDPNTKTE ITFDDFKTEV LSDYKLAVTS RECSLLGRRE VLTGKAKFGI FGDGKEIPQI
AWAKAFRNGD FRSGYYRDQT FMMAIGELTI EQFFAGLYAN TDIKEEPMSA GRQMGGHFAT
HSLDENGQWK NLTEQKNSSA DISPTAGQMP RLLGLAQASK IYREVKGIDT TMFSKEGNEI
AWGTIGNAST SEGLFFETIN AAGVLQVPMV ISIWDDNYGI SVHARHQTTK ENISEILKGF
QREEDQKGYE IFRVDGWNYP QLIDTYQRAA KISRNEHVPV MIHVQELTQP QGHSTSGSHE
RYKNKERLAW EAEYDCNVQM RLWIIDNNIA TDEELTAIER IIKKSVREGK KAAWEACINP
IITERKEALS LLEQLAASSP NGVFITKLKN ELEGFDEPLR RNILTASRKA LRYVVSESSS
EKEALQNWIT NYINTIQPKY SSHLHSESPK SALKQAEILP TYDSNTEEVD GRVVLRENFD
AIFSNYPEAL IFGEDAGYIG DVNQGLEGLQ EKHGELRVSD TGIREATIIG QGIGMAMRGL
RPIAEIQYLD YIMYAIQIMS DDLATVQYRT KGRQKAPLIV RTRGHRLEGI WHSGSQMGGI
LNLIRGIHVL VPRNMTKAAG FYNTLLDSDE PALVIECLNG YRLKEKLPNN IGEFKTPIGV
VETIREGNDI TLISYGSTLR LVEKAAKELQ VVGIDSEIID VQSLLPFDLN HDIVKSIAKT
NRVMVIDEDV KGGASAYILN EILNTQDAFQ YLDSTPKTLA AKPHRPAYGT DGDYFSKPSA
EDIFEAIYDV MHELSPADYP KLR
//
