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Database: UniProt
Entry: S7W144_9MICO
LinkDB: S7W144_9MICO
Original site: S7W144_9MICO 
ID   S7W144_9MICO            Unreviewed;       406 AA.
AC   S7W144;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   05-JUN-2019, entry version 27.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   ORFNames=ADILRU_1440 {ECO:0000313|EMBL:EPR76306.1};
OS   Leifsonia rubra CMS 76R.
OC   Bacteria; Actinobacteria; Micrococcales; Microbacteriaceae; Leifsonia.
OX   NCBI_TaxID=1348338 {ECO:0000313|EMBL:EPR76306.1, ECO:0000313|Proteomes:UP000017024};
RN   [1] {ECO:0000313|EMBL:EPR76306.1, ECO:0000313|Proteomes:UP000017024}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CMS 76R {ECO:0000313|EMBL:EPR76306.1,
RC   ECO:0000313|Proteomes:UP000017024};
RX   PubMed=23950134;
RA   Kumar Pinnaka A., Singh A., Ara S., Begum Z., Reddy G.S., Shivaji S.;
RT   "Draft Genome Sequence of Leifsonia rubra Strain CMS 76RT, Isolated
RT   from a Cyanobacterial Mat Sample from a Pond in Wright Valley,
RT   McMurdo, Antarctica.";
RL   Genome Announc. 1:e00633-13(2013).
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003423}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EPR76306.1}.
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DR   EMBL; ATIA01000084; EPR76306.1; -; Genomic_DNA.
DR   RefSeq; WP_021809552.1; NZ_ATIA01000084.1.
DR   STRING; 1348338.ADILRU_1440; -.
DR   EnsemblBacteria; EPR76306; EPR76306; ADILRU_1440.
DR   PATRIC; fig|1348338.3.peg.1431; -.
DR   OrthoDB; 1626282at2; -.
DR   Proteomes; UP000017024; Unassembled WGS sequence.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; -; 1.
DR   Gene3D; 4.10.320.10; -; 1.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF02817; E3_binding; 1.
DR   SUPFAM; SSF47005; SSF47005; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS00189; LIPOYL; 1.
DR   PROSITE; PS51826; PSBD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:EPR76306.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017024};
KW   Lipoyl {ECO:0000256|RuleBase:RU003423, ECO:0000256|SAAS:SAAS00065550};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017024};
KW   Transferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:EPR76306.1}.
FT   DOMAIN        3     78       Lipoyl-binding. {ECO:0000259|PROSITE:
FT                                PS50968}.
FT   DOMAIN      122    159       Peripheral subunit-binding (PSBD).
FT                                {ECO:0000259|PROSITE:PS51826}.
FT   REGION      163    191       Disordered. {ECO:0000256|MobiDB-lite:
FT                                S7W144}.
SQ   SEQUENCE   406 AA;  41618 MW;  3330C36920526EC8 CRC64;
     MAELPLTMPK MSMTMEEGTM VAWLKQVGDP VRSGEPICEV ATDKVDMEVE SPFDGVLARI
     IAEPDDVYPV GDVIAYITTD ADDLLGGLFD EPADEAPAAA PANDDVAPVA AAPAPIETGW
     VSAVPAARGV AEQHNIDLAT VTPTGPDNTV RVADVEAAAA AAEGQGSAAA TPAAAAPAAA
     TPAKTEDPVE ARRLRTRKQV AKVMSASALV PQFTAYVDLD LSALAAVRKT TLGGASWTAL
     FVRAQAIALA ENAALNGTWT DEGVAANDHI GIALAIDSPS GLIAPVLMNS HEGTLAELVA
     EIATVVGETR SGTLPPARLG GGTSVFSNLG GFGVESFNAL LTPPQSTALS SGAVKPRMRV
     FDDETFGVRL SCTIGLTVDH RVADGADAAR MLAIITNLVA TPERLL
//
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