ID   S7X6S3_9FLAO            Unreviewed;       316 AA.
AC   S7X6S3;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=dTDP-glucose 4,6-dehydratase {ECO:0000313|EMBL:EPR74759.1};
DE            EC=4.2.1.46 {ECO:0000313|EMBL:EPR74759.1};
GN   ORFNames=ADIWIN_0123 {ECO:0000313|EMBL:EPR74759.1};
OS   Winogradskyella psychrotolerans RS-3.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Winogradskyella.
OX   NCBI_TaxID=641526 {ECO:0000313|EMBL:EPR74759.1, ECO:0000313|Proteomes:UP000014962};
RN   [1] {ECO:0000313|EMBL:EPR74759.1, ECO:0000313|Proteomes:UP000014962}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS-3 {ECO:0000313|EMBL:EPR74759.1,
RC   ECO:0000313|Proteomes:UP000014962};
RX   PubMed=23950132;
RA   Kumar Pinnaka A., Ara S., Singh A., Shivaji S.;
RT   "Draft Genome Sequence of Winogradskyella psychrotolerans RS-3T, Isolated
RT   from the Marine Transect of Kongsfjorden, Ny-Alesund, Svalbard, Arctic
RT   Ocean.";
RL   Genome Announc. 1:e00630-e00613(2013).
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|ARBA:ARBA00001911};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EPR74759.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ATMR01000007; EPR74759.1; -; Genomic_DNA.
DR   RefSeq; WP_020895724.1; NZ_ATMR01000007.1.
DR   AlphaFoldDB; S7X6S3; -.
DR   STRING; 641526.ADIWIN_0123; -.
DR   PATRIC; fig|641526.4.peg.122; -.
DR   eggNOG; COG0451; Bacteria.
DR   OrthoDB; 9801785at2; -.
DR   UniPathway; UPA00796; UER00771.
DR   Proteomes; UP000014962; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0048040; F:UDP-glucuronate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042732; P:D-xylose metabolic process; IEA:InterPro.
DR   GO; GO:0033320; P:UDP-D-xylose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05230; UGD_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR044516; UXS.
DR   PANTHER; PTHR43078:SF6; UDP-GLUCURONIC ACID DECARBOXYLASE 1; 1.
DR   PANTHER; PTHR43078; UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:EPR74759.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014962}.
FT   DOMAIN          4..239
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
SQ   SEQUENCE   316 AA;  35695 MW;  A6B89F243D5ECCE2 CRC64;
     MKRILVTGGA GFVGSHLCER LLNEGNEVIC LDNYFTGSKQ NIEHLMDHHY FELVRHDIIN
     PYMIEVDEIY NLACPASPVH YQYNPIKTIK TSVMGAINML GLAKRVGAKI LQASTSEVYG
     DPSVHPQPES YWGNVNPIGL RSCYDEGKRC AETLFMDYHK QNEVDVKIIR IFNTYGPRMH
     PQDGRVVSNF IMQALKGDDI TIFGEGTQTR SFQFVDDLVE GMIRMMSSRD GFVGPVNIGN
     PVEFTMLELA QHVIALTNSK SKIIHLPLPQ DDPMQRQPNI DLAKKELNDW EPNVHLKEGL
     GKTIAYFDEL IKANKA
//