ID   S7XJA5_SPRLO            Unreviewed;       385 AA.
AC   S7XJA5;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Saccharopine dehydrogenase {ECO:0000313|EMBL:EPR79104.1};
GN   ORFNames=SLOPH_2177 {ECO:0000313|EMBL:EPR79104.1};
OS   Spraguea lophii (strain 42_110) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Spraguidae;
OC   Spraguea.
OX   NCBI_TaxID=1358809 {ECO:0000313|EMBL:EPR79104.1, ECO:0000313|Proteomes:UP000014978};
RN   [1] {ECO:0000313|Proteomes:UP000014978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=42_110 {ECO:0000313|Proteomes:UP000014978};
RX   PubMed=23990793; DOI=10.1371/journal.pgen.1003676;
RA   Campbell S.E., Williams T.A., Yousuf A., Soanes D.M., Paszkiewicz K.H.,
RA   Williams B.A.P.;
RT   "The genome of Spraguea lophii and the basis of host-microsporidian
RT   interactions.";
RL   PLoS Genet. 9:E1003676-E1003676(2013).
CC   -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00038048}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EPR79104.1}.
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DR   EMBL; ATCN01000402; EPR79104.1; -; Genomic_DNA.
DR   AlphaFoldDB; S7XJA5; -.
DR   VEuPathDB; MicrosporidiaDB:SLOPH_2177; -.
DR   HOGENOM; CLU_031002_1_0_1; -.
DR   InParanoid; S7XJA5; -.
DR   OMA; KRPVQMH; -.
DR   OrthoDB; 5479972at2759; -.
DR   Proteomes; UP000014978; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR005097; Sacchrp_dh_NADP.
DR   PANTHER; PTHR12286:SF5; SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE; 1.
DR   PANTHER; PTHR12286; UNCHARACTERIZED; 1.
DR   Pfam; PF03435; Sacchrp_dh_NADP; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014978};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        251..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          17..125
FT                   /note="Saccharopine dehydrogenase NADP binding"
FT                   /evidence="ECO:0000259|Pfam:PF03435"
SQ   SEQUENCE   385 AA;  43632 MW;  65560BD3B68CB13B CRC64;
     MDLSQRKYDV IIYGGSSITA KYTLKEFMVY NLKMAVAGRN YDRIDKNVDY VVDILECSIE
     NIEKISKLTK ILVNCAGPFI FCGEEVVKGC INTGTHYIDV TGENIFIEKI LHKYNEEAKK
     KGVLILNACG FDSIPADIGS EYLKRNMEGI NKSITSVLQF EKCQINKTSY ISLVHSLSAI
     GELRKIRGNK KKISKEGKQP IKKLTYSKET KSWWTIFMGT DIAIVKRTQK YFKEHGEEPM
     KYACYIDTGN LFNTILFWIG FFIIFAMAKF SFTKKLLLKF PTFFTNGIVP KTKPTEEEIE
     KGKFKMLFFG ESYVDGVLTK KKLTIEGGDP GYVATPYSAV STAQVLLEMI NQNKVTGGIH
     TPGSVLDIYK MVNLLEDKGI TFKIE
//