ID   S7XPR1_SPRLO            Unreviewed;       594 AA.
AC   S7XPR1;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Metallopeptidase M24 {ECO:0000313|EMBL:EPR77948.1};
GN   ORFNames=SLOPH_2653 {ECO:0000313|EMBL:EPR77948.1};
OS   Spraguea lophii (strain 42_110) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Spraguidae;
OC   Spraguea.
OX   NCBI_TaxID=1358809 {ECO:0000313|EMBL:EPR77948.1, ECO:0000313|Proteomes:UP000014978};
RN   [1] {ECO:0000313|Proteomes:UP000014978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=42_110 {ECO:0000313|Proteomes:UP000014978};
RX   PubMed=23990793; DOI=10.1371/journal.pgen.1003676;
RA   Campbell S.E., Williams T.A., Yousuf A., Soanes D.M., Paszkiewicz K.H.,
RA   Williams B.A.P.;
RT   "The genome of Spraguea lophii and the basis of host-microsporidian
RT   interactions.";
RL   PLoS Genet. 9:E1003676-E1003676(2013).
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|ARBA:ARBA00008766}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EPR77948.1}.
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DR   EMBL; ATCN01001135; EPR77948.1; -; Genomic_DNA.
DR   AlphaFoldDB; S7XPR1; -.
DR   STRING; 1358809.S7XPR1; -.
DR   VEuPathDB; MicrosporidiaDB:SLOPH_2653; -.
DR   HOGENOM; CLU_011781_2_4_1; -.
DR   InParanoid; S7XPR1; -.
DR   OMA; NARMINI; -.
DR   OrthoDB; 869at2759; -.
DR   Proteomes; UP000014978; Unassembled WGS sequence.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF16189; Creatinase_N_2; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000014978}.
FT   DOMAIN          11..124
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          341..523
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          538..590
FT                   /note="Peptidase M24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
SQ   SEQUENCE   594 AA;  68932 MW;  C6501A0FC1D7EE1B CRC64;
     MNLLPLMNLY KHGLDGYIVF NSDEHLSEFV GDADKRVEFL SGFTGSNGTI TYLKENKFFY
     TDSRYTLMAK KQLKIGFKVR ENIVNDINQL EKGKIGLNKK LISYQRYKSL RNSIKEEIEF
     VDVELIDSLW KDKLKKISKE LFTCVEESIF YKKLIQKPTV KKYLDEIDRL VKQDDIDPLE
     AVKGYLKGDE AYLLTELGDI AWLLNLRGAD IQYVPEFYSY AYVKKDKIYV FLGDLNGKVD
     KNPYTFETVN KDWILEKYKD HNIEILDYNN FYEFLDKIKE EKIYASENIN QYIYEKLEQK
     IHISSFVAET KSIKSRRQLK NVFIANIFDG VALVNLFGYL EYQRPDITEI EVAEKLKDLK
     KRNELFLMES FRSIVGSGDN GAIIHHDSSD KKIDYENTLL LIDAGSQYSI GTTDISRTLG
     FGKPTVDQIK NYTLVLKGQL EASMVMAPQR YFSSAVDIAA RKYLWESQKD YGHGTGHGVG
     YVLDVHEMPP NVSIRGEVKP HQLYSIEPGF YAEGKYGIRL ENLAFSYSKN NFLRSFILTP
     VPIQITLVDK SLLTGNLYEC LDKYNKMVKE LLLDYLDEDG RNWLMNNARM INIH
//