ID S7XVJ4_SPRLO Unreviewed; 386 AA.
AC S7XVJ4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=NADPH cytochrome p450 reductase {ECO:0000313|EMBL:EPR79908.1};
GN ORFNames=SLOPH_1387 {ECO:0000313|EMBL:EPR79908.1};
OS Spraguea lophii (strain 42_110) (Microsporidian parasite).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Spraguidae;
OC Spraguea.
OX NCBI_TaxID=1358809 {ECO:0000313|EMBL:EPR79908.1, ECO:0000313|Proteomes:UP000014978};
RN [1] {ECO:0000313|Proteomes:UP000014978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=42_110 {ECO:0000313|Proteomes:UP000014978};
RX PubMed=23990793; DOI=10.1371/journal.pgen.1003676;
RA Campbell S.E., Williams T.A., Yousuf A., Soanes D.M., Paszkiewicz K.H.,
RA Williams B.A.P.;
RT "The genome of Spraguea lophii and the basis of host-microsporidian
RT interactions.";
RL PLoS Genet. 9:E1003676-E1003676(2013).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPR79908.1}.
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DR EMBL; ATCN01000076; EPR79908.1; -; Genomic_DNA.
DR AlphaFoldDB; S7XVJ4; -.
DR STRING; 1358809.S7XVJ4; -.
DR VEuPathDB; MicrosporidiaDB:SLOPH_1387; -.
DR HOGENOM; CLU_060137_0_0_1; -.
DR InParanoid; S7XVJ4; -.
DR OMA; FISFIRN; -.
DR OrthoDB; 9164at2759; -.
DR Proteomes; UP000014978; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR19384:SF84; METHIONINE SYNTHASE REDUCTASE; 1.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000014978}.
FT DOMAIN 54..221
FT /note="Sulfite reductase [NADPH] flavoprotein alpha-
FT component-like FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF00667"
SQ SEQUENCE 386 AA; 45616 MW; 09514F9C2B097333 CRC64;
MLNLPHPLPI FTFKPSDDSW KENLIISSIG NDLFQPVKIL DNFLTFKNIF YNNISKANIN
KIEKLSTTWK KVYKVELDST LSYNPGDSVG IIVSNREIYV NEIFKILNIK DRSIEIKIKD
KKSKEFKIVY RGLISDYFRN VFSFTEIPKK SFLKAIIECS EEKEIIKFLV SKEGSKKYFE
LLKYNLIEIL TFLKAKPTLE HLVYFANNIK PRYYSLTNED KNLEFYIGVE NTEHIKGHCS
SFFDNIYFNS KTHKEKHVYV LGVKKNEFFN LRKSKKYLFI SCGIGITPFI SFSNHIDNYW
VIHGTRSKQD DLTTHLRKKG EITTIISKHE RIENFIKNEL VGDFIKENCL LYICGPIEMQ
KKVYNTIKEF YNFVLNEKRV FFDSWL
//
