ID S7ZCA9_PENO1 Unreviewed; 4922 AA.
AC S7ZCA9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=PDE_03211 {ECO:0000313|EMBL:EPS28265.1};
OS Penicillium oxalicum (strain 114-2 / CGMCC 5302) (Penicillium decumbens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=933388 {ECO:0000313|EMBL:EPS28265.1, ECO:0000313|Proteomes:UP000019376};
RN [1] {ECO:0000313|EMBL:EPS28265.1, ECO:0000313|Proteomes:UP000019376}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=114-2 / CGMCC 5302 {ECO:0000313|Proteomes:UP000019376};
RX PubMed=23383313; DOI=10.1371/journal.pone.0055185;
RA Liu G., Zhang L., Wei X., Zou G., Qin Y., Ma L., Li J., Zheng H., Wang S.,
RA Wang C., Xun L., Zhao G.-P., Zhou Z., Qu Y.;
RT "Genomic and secretomic analyses reveal unique features of the
RT lignocellulolytic enzyme system of Penicillium decumbens.";
RL PLoS ONE 8:E55185-E55185(2013).
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB644410; EPS28265.1; -; Genomic_DNA.
DR STRING; 933388.S7ZCA9; -.
DR eggNOG; KOG1808; Eukaryota.
DR HOGENOM; CLU_000050_0_2_1; -.
DR OrthoDB; 1221059at2759; -.
DR PhylomeDB; S7ZCA9; -.
DR Proteomes; UP000019376; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 9.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SMART; SM00382; AAA; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000019376}.
FT DOMAIN 4706..4910
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 744..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4072..4547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4568..4598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4107..4124
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4125..4175
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4183..4228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4229..4255
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4256..4273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4274..4305
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4313..4374
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4397..4432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4433..4448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4466..4483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4497..4513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4517..4535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4922 AA; 548152 MW; 010999DDB578C1E9 CRC64;
MNGRPVYERT LTESELLEQL PNELAGLIQS ASETQQLHAL ALSALHSQFT ESVFQLYEPL
IVELGARWIR PDTGADPIDV LAAFARILPI AAYLLPFASQ HASSQSGSLS ALSGSKELTL
RQLGSEEIRK ILLALFRLMS FDLETFAKVV SPIQLQSLFP HEDRVIRYLA IRCFALYMHA
ADAATEKMLH INTGVEPIEG HWEGITIDYR LLGLWEERRW ETLEDHKRLK STTSLESEEM
ALVDGMKNAL TARSANVCGI LVPRMKDAEA FESSVVKTPT TTANIRRIAR SLLETKPILL
VGLPNSGKTS LINDIAGNMG QADTMITLHL NEQTDAKSLL GMYATSSATG SFSWQPGVLT
KAAREGRWVL IEDLDRAPSE VLGLILPIIE RGELTIASRR ERIKCAEGFK IIATMKSSYN
MTGEEIAPSS SMLGSRLWQR VHVQSLSIDE MKDVILQKFP LLESRVPTIM EVYRRVCSAF
HGSLAIKGSQ GRTPGFRDLI KLCNRLHRRL QLIGAKTGFE AAPESIEDEI LLDVVDVFLK
YLPEKSMQSS LAGVVAEALH ISPQRARFCL EERAPTYHDK SSSLVLGREV LQKIKVPSGA
AQRLAAAASR FASTRSALSI MEQVAASVQM AEPVLLVGET GIGKTTVIQQ LATLMRQKLT
VVNLSQQSES TDLLGGFKPV SIRTMAVPML DEFTQLFELT FSAKKNQKFL ASVSRSVASG
NWVRLVNLWH EAVRLANGVF NPARKANADD DEQQPAKKRK LDSPKYQQLR QRWESFESQL
SDFEAQVSQG DAKFAFAFVQ GKIVRALRNG EWVLLDEINL ASPDTLENIA SLLNHGSEGS
PSVLLSEAGD VERVFGHSDF RIFGAMNPAT DAGKRDLPPG LRSRFTEFYV HSPDTELDDL
LALIDKYLGN LTIGDQRAVS DLAQLYLETK KLSNSNKLTD GAGQRPHFSI RTLVRALIYV
IDHAHVYGLR RAIYEGFSMS FLTVLSLESE QSLSPLLEKY IFENAKNAKS LLGRTPRAPD
DGLDYVQFKH YWMRRGPMTP EEQPHYIITP FIEKNLKNLV RASSTRRFPV LLQGPTSAGK
TSMIEYLAKV SGNKFVRINN HEHTDLQEYL GSYISSDDGS LRYQEGVLVE ALRNGYWIVL
DELNLAPSDV LEALNRLLDD NRELFIPETQ EVVHPHPNFM LFATQNPAGL YGGRKVLSRA
FRNRFLELHF DDIPESELEF ILKERSQIAP SFCSRIVSVY RRLSLLRQSN RLFEQKNSFA
TLRDLFRWAL RDADDREQLA VNGYMLLAER VRNPQEKAAV KSVIEEVMKV KLDDDLLYSE
NQLRLSIPEA AELPSGIVWT KAMRRLFVLV SRALKNNEPI LLVGETGCGK TQLCQAVAEA
FKRELFIVNA HVNLETGDLI GAQRPIRNRA AIEKQVLEDL QHLFHGQEVA GLSLEQLKHE
FFSLDGQRKQ EMDQSVVYRI EKNLIRCNAL FEWSDGSLIT AMRTGQFFLL DEISLADDSV
LERLNSVLEP ARSILLAEKG PIDSMVVAHA GFQFMSTMNP GGDYGKRELS AALRNRMTEI
WAPQLSEDED ILPILQMRLT LKDEKIARSM LLFAKWFKST FQNATNTSLS LRDLLAWVDF
VNTCENQDVQ FAVVQGAAMV FVDTLGANPA AMLAVSLSNL DENRQKCLEK VGELFSVDAS
KIYWQNSTVS LDSGHLKIGP FSLPVVGDAN PDPQFTMDAP TTVANSVRIA RGLQSSKPIL
MEGSPGVGKT TLVTALAKAL GKPLTRINLS EQTDLTDLFG SDVPVEGGDV GQFTWRDAPF
LRAMQRGDWV LLDEMNLASQ SVLEGLNSCL DHRQQVYIAE LDQTFKRHPD FVLFAAQNPH
HQGGGRKGLP ASFVNRFTVV YADSFTDADL KKICAKLFPG SPQSQTEKLV DFISSLNKAI
VTERRLGAVG GPWEVNLRDI QRWLQLADRG DLQISTRHFL DVVISQRFRT LEDRTQVSQI
YDRIFSAPEA DEKSYFHNLT PDYMQVGLGI LNRDPLLQRS FGPNVRVLPR DLQILESLIL
CIDNSWPSIL VGPAGCGKTT LIKKLAAING ASLEELALSA DTDTMDLIGG FEQIDHRREI
SSLVHDVQVF LQRQVIESFS SAAVSESVAL ALQVCQHFQL QELPLETVLS SLASLCQSFP
DSTLEGFHKR AQDLVHAMEN SDKMKVGFEW TEGVLTRAVQ NGSWVILDNA NLCNPSVLDR
LNSLTEPNGM LILNEQRTED GSARVITPHP AFRLFMTMDP RHGELSRAMR NRCTEICFMA
NQQLELTPSL TPSYTCESSL YRLRHVWKST KTLASTSSAT REEDFLEICF DHLSPADINY
LGGSSHIFLP NSTGPDLKER VSDNLQRYVS LVQENENWKP QDVLNEQVSM SGALLAIKGR
RQPVHPLINE PLLSVIGGRR YRAKVIVLAY LQEFKLELYR LKKRLVQSNE SANQHKPSQM
TRLERSLASD RIPSLMKDST QPVGSFLSDC GQALYDYINA FGEESLESSE FVSALRMVFS
LCYDIYRITN LSQLNEGEFQ VYLQIGRTVC ASLRDSSPTL QPLGRALANA LSRFQAGWAL
TTGLSMQKMW DAWRQVTPAS PDQLALLIDL ENTVAHFTDL ALQTRVEVSQ LSAVWNSLMN
AHKFILQDGA DGDLLLNEIK QTVTQLNQAV RRSNATQQPY FSKEFEALCQ YHDIEAIHSK
QFVQSVVPLL AGRRARSLDA SISHSRVPEM LNRLALFSGA GVKSSGALAI GGVLSLSLLE
RLTSVNGTTL GQMDLLQAET KALSEAITLS TGHVGTEQAR VLSRAIAALT AELVSCHSEF
FDSTSVGQLL STLKQLERGH SDENWNYPSV VTDSTLPPNH YFVSFAQVAL PALVSSLIKS
ITSDQAVRVT GRAAVQLAVI LLRLFVPDKA FDPSLDLVVQ RQRYQRRLDE FTSKSNAILA
FEHNFSGESS NLRSNLLKEE IQQLGSAPPP SSVTRPEKSE LSLLHGEFLN LINSVVKRSP
EKMVESSDMI AESRETIQLL RDNIAQLCSR LSTNYRSYDD ITVPIVRFLQ LLDLGLFVAS
SEDTQPSTVQ DIQPLSERTP FMGGYQHPVL SSSVVAPSHS QGNAVEMRLH ELTALWTAKD
ADSSIIHVKS FRDSLRRIFS DFHYLWKTQL KEDQEKEAEK NELYRYRGSW EDEEEVNDAE
LHQLFPTYDD GQIEAAVNDR IDPRAIAVRI SALHAKIVNA QRSGDALPQF VKESGQLLGS
MWSSSQTSFS PVSPQSHLPA VLLLLEDVMN TGSEMKTKKN YNFYTDPNLA EARKLVDLTL
SVQSRFAQIQ IAWPEHAVLQ EVINCCSEIL QFKHTEPVAK FLTKLEKLHS YVHEWQLVAS
REYSAAALYD EITATTVGWR RLELTTWAKL LDLEKERCNE DVSSWWFVAY EALLAVPLQM
AENGEKEMGA HIQGVIFTLE QFFQSTSLGQ FARRLQLVSD FQSLLVAFTR DYDCLTPLVT
ALANFLSHYR PFEPSVEKIL HDKRAVLEKD IKEQIQLASW KDTNIVALKE SARRSHVKLF
KLVRKYREAL AQPIQAVLEQ GLPDLTEVHG SQSPTQATLA PVLLTDVLPA CQSQQGIWSS
RALRFQNPDG TARNMTNLYS SIPTEFDIAK DLDDFTVSII ENINEFKSAT PKTLTEENKD
DVQHLKVQKR RLFADTLKRL FEMGVKRNAG TSLIEAQLSL SQVLSTSSAF DLVNVTKGHG
QLQSADSYFH RLLDLLPRAR LASRNYSDEL SNVEVSRSMG SIEYLLFIIR RQRGVLSPAL
SDLSELGSTL DKARQLWTVG SGKLIKDGDA GGDETLGLTR LIAWLSPILG LALQIIEVHS
RFSGISVTSL SQELKAKKAA LDDLCLALRS QPSLPAGIAS SGQKELVQRA RQLLSQLGHD
IQTWVSDRPD LSFALEQIRP WIKSEHVPTA GQIGAGSVPI ERFDASLMSA VDKMLVGLQQ
LKDVPNGLTF DGLMSRSDEF FSRASKALHL KEITGSLAGV LDRLQNLQDE SSSALPLAAA
LVASILPIAT QFYEICQDLT LRFTSVHREI CKTSYVLTKT FTQVASEGFC SPAEASQDEG
KEGKMESGTG LGDGEGAEDI SKDVGDDEDL SELAQQAQKE DAEKDEMEDS AEAVNMDQEE
LEGETGDHKE EEGEDEDKGD EDDENEDDID EEVGSVDGLD SGAVDEKLWD GANDEQQKET
ENEEGKGQAE DDQQTAAQEQ KKDGEEGPKG EEGEEDEDEE EDEEAPDDEG EAIGREDMDV
TDPQAKEQET LELPEEMQLD GDDQGEGDEG EDDDGMDDLS DMGPLPEEEQ NEKQQADGDE
DEDEDMDMNA DEQAVGDDEE MGEEGEETNE GEGQEEENEA GGDEAEDPEQ EEFLTQRDEN
EAAGDEVAPS DAVNGGLAAD QDQNENKGAS GDAQQESGST DPTANAEQQT GAAKDSEESK
RSRDAGGAED SAPNEPQMQA FKKLGDILEQ WHRRQKEVLN PSQEEEDSQP LPQDTDMADA
DFEHLKDDDD VADTQALGQA NDDQAQGLDQ NKGVESENQP GERDALPDIT DDMQETLENQ
LQDEMQIDRE APPRDGESAG AFIPGDRPSG NSTDGALGTE DINEELDEVD SQLAAIHLSS
SLPPLTPESE ARRLWSHYEN ATNDLSLSLT EQLRLILAPT MATKLRGDFR TGKRLNIKRI
IPYIASQYKR DKIWMRRSIP SKRNYQIMLA VDDSKSMLES GSGQLAFETL ALVAKSLSML
EAGDLCVLGF GNEDHVRVAH EFGKPFSSEA GSQVFQHFSY QQTGTNVRKL IADSIALFRE
ARWKRSPGSG SADLWQLQLI ISDGICEDHD TIRRLVRQAL EERIMIVFII VDAVKGSSIL
DLSQASFEAD PNSGGEMKLR MKRYLENFPF PYYLVVRDVR ELPSVLATAL KQWFAEVVDV
SS
//
