ID S7ZTL2_PENO1 Unreviewed; 1072 AA.
AC S7ZTL2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=Protein HIR {ECO:0000256|RuleBase:RU364014};
GN ORFNames=PDE_07070 {ECO:0000313|EMBL:EPS32111.1};
OS Penicillium oxalicum (strain 114-2 / CGMCC 5302) (Penicillium decumbens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=933388 {ECO:0000313|EMBL:EPS32111.1, ECO:0000313|Proteomes:UP000019376};
RN [1] {ECO:0000313|EMBL:EPS32111.1, ECO:0000313|Proteomes:UP000019376}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=114-2 / CGMCC 5302 {ECO:0000313|Proteomes:UP000019376};
RX PubMed=23383313; DOI=10.1371/journal.pone.0055185;
RA Liu G., Zhang L., Wei X., Zou G., Qin Y., Ma L., Li J., Zheng H., Wang S.,
RA Wang C., Xun L., Zhao G.-P., Zhou Z., Qu Y.;
RT "Genomic and secretomic analyses reveal unique features of the
RT lignocellulolytic enzyme system of Penicillium decumbens.";
RL PLoS ONE 8:E55185-E55185(2013).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|ARBA:ARBA00002677,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
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DR EMBL; KB644414; EPS32111.1; -; Genomic_DNA.
DR AlphaFoldDB; S7ZTL2; -.
DR STRING; 933388.S7ZTL2; -.
DR eggNOG; KOG0973; Eukaryota.
DR HOGENOM; CLU_004372_3_1_1; -.
DR OrthoDB; 5478541at2759; -.
DR PhylomeDB; S7ZTL2; -.
DR Proteomes; UP000019376; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF101908; Putative isomerase YbhE; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000019376};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 20..47
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 67..108
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 127..168
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 169..210
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 756..990
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 460..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1072 AA; 115880 MW; F9BF0A30F489694B CRC64;
MHIIKPVWLT HGGERKDFEV YSCDVSPDGK RLVTAAGDGY VRIWSTEAIH NTDKPEFASK
PKQLASMSNH SGTIHTVRFS PNGKYLASGA DDKIVCVYTL DSSPPTHSTF GSDEAPPVEN
WRTIRRLIGH DNDVQDLGWS HDSSILVSVG LDSKIVVWSG HTFEKLKTIV VHQSHVKGIT
FDPANKYFAT ASDDRTVRIF RFTSPGPNST SHDQMNNFML EHTITAPFAN SPLTAYFRRC
SWSPDGMHIA AANAVNGPVS SVAIINRGSW DGDINLIGHE APVEVCSFSP RLYSKEPIDK
HQTDNHVAQH HITVIACAGA DKSLSVWITS NARPIVVAQE MAAKSMSDLA WSPDGKCLYA
TALDGTILAV RFEDGELGWA TEMEENEKSL TKFGTNRKGA GITETTDGLL LEEQSKASEL
RGVEGRMGAL MGDGHAQPAA TNGNSAAAAA AAVATAAAAP SNGTTPARVP SPAPESAKTQ
TNGTSTPATD AAKPDPYMAK LERLKQRPTY TKDGRKRIAP LLVSGAGAGE SSLPQTRLMA
SVSSQVKGDA PTSIVDLSKP FDGLPKGGLT TLLFGNKRRL AQLEGEEEGQ VEKRVAVASQ
NGATPILSNT LDGLLPAVVE SPVSGQQPTP EFIRPAVTNP CMSISQTRLA VPKIRSFILR
ALDPNGKPTE PPNQAGESNA KDKGRIDVVF EAKNPSPASL TGRAVDREPV RLTLFRGEQP
LWQDFLPKCV LLVTGNQNLW AAACEDGSVY LWTPAGRRLV SALVLEAQPV ILECNGPWVL
CISSVGMCYV WNVKHLSSPH PPISLQPVLD AAIHTLGGNP TSAPAVTDAR INSEGRIVVS
LTNGEGYSYS PAMYTWQRVS EAWWAVGSQY WNSTDAPVGN LQAREGSQEN KESKAAVSAG
IIPFLERNTT NETLLRGRAY FLQRLIKVLL SREGYETFES SVSIAHLENR MAAALSLGAK
EEFRLYLNMY AKRIGAEGLK GKVEELLKGL IGGLFDDEDG SETVAKLQAN EHEGRNWREG
SDDLCGWPRE TLLKEVILAL GKYRELQRVT VPYAKLLDMV DTTSEAGDAM DL
//
