ID S8A4D4_DACHA Unreviewed; 1140 AA.
AC S8A4D4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=H072_10549 {ECO:0000313|EMBL:EPS35981.1};
OS Dactylellina haptotyla (strain CBS 200.50) (Nematode-trapping fungus)
OS (Monacrosporium haptotylum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Orbiliomycetes;
OC Orbiliales; Orbiliaceae; Dactylellina.
OX NCBI_TaxID=1284197 {ECO:0000313|EMBL:EPS35981.1, ECO:0000313|Proteomes:UP000015100};
RN [1] {ECO:0000313|EMBL:EPS35981.1, ECO:0000313|Proteomes:UP000015100}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 200.50 {ECO:0000313|EMBL:EPS35981.1,
RC ECO:0000313|Proteomes:UP000015100};
RX PubMed=24244185;
RA Meerupati T., Andersson K.M., Friman E., Kumar D., Tunlid A., Ahren D.;
RT "Genomic mechanisms accounting for the adaptation to parasitism in
RT nematode-trapping fungi.";
RL PLoS Genet. 9:E1003909-E1003909(2013).
RN [2] {ECO:0000313|Proteomes:UP000015100}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 200.50 {ECO:0000313|Proteomes:UP000015100};
RA Ahren D.G.;
RT "Genomic mechanisms accounting for the adaptation to parasitism in
RT nematode-trapping fungi.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPS35981.1}.
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DR EMBL; AQGS01000992; EPS35981.1; -; Genomic_DNA.
DR RefSeq; XP_011116004.1; XM_011117702.1.
DR AlphaFoldDB; S8A4D4; -.
DR STRING; 1284197.S8A4D4; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_005431_1_0_1; -.
DR OMA; HIAKWVA; -.
DR OrthoDB; 4819765at2759; -.
DR Proteomes; UP000015100; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000015100}.
FT DOMAIN 624..749
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 880..1124
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 188..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1140 AA; 126811 MW; 75B7C1E32CAA9DF2 CRC64;
MAIFEINDVD SNSERRLHFC LSLLLTRVLP HTSQGPHQHS KMITAAGAGA SFCLATPARL
RPQNQRNPRI VGAGQPSQTT LGSYNLQRTQ SAASNYSQTA GSTYAPSISS PTRADRIPEV
TEISKSRPFF PAPISPPPIS HPVFRNPSFS ASSAALYHDA LLHEEGYLRP KSPGSLYSYN
TSSSGATARQ FSSLSESLEP EDLSDDDGEI SPTSPAAPRQ FQTYMTSPLP GLPSHVHNSQ
LDLQAAFTGN TSDLVVLQSD SPTGLEQAHK IADAMTYSLD QSSQEICIVV LGMENSGKST
FIQKYNGSKR MPINGVSQRV YRFDDLRYVV RLVEMDLSAL DIRNSNFTWP SLHDGTEIMT
ADGILVLFDV TDRTSVEKIP DVIDFFFKAD IPTLLVASKC DSPAQMRDLQ PDSVEELRRT
LGVEVMETSS SDAGQSQKRC VSLMLSNIIH RKAEVKAASQ ANARRRANSS ALSGRSVSPL
SDPKPSHGRA SSELSISVSK SREQPEAGKG HHGRTTRSLS ASNGTLLSPN RTSVSTPNSP
LSHHIRPYMQ DFNPSFGKEN LDEDDFSYMN ADGATYGSMA ANFLRSKSTS AASPHAPHEK
LEHSTSMSEV MFDRDNGIQR ISSGSGKYTG LAWEDLVDRL LAYPMSRADQ DFATVMLCFF
RKFAAPVDLL DSILAKFARV NKEESIFLLQ MNEKIRILSR LHWWVWECPG DFANVSTRQR
TIDFARSLEG NRTFAGMAKD IIAILNQPSI EDEDQIWGKK DTDSHRLSMP SYFIHSPSSP
TTPNHSLPWV QPNALPPRNM SIVSTLSLKS GGSDDTAPAL HSPHSDRPRK DSYVSTASLS
PTLDAQAGMM NISSMLEGLS HGQTSPQMIK EQYSIFMELP DEDIAHELTR IDWTLFSRIK
PRDFVRHVSV PAAEKERTPS LKYMNKLIEH FNRVAYWVAS IILERPKAKH RARALEKFMN
IAWILRHMNN YNSLGAVIAG VNGLAIHRLA LTRSLVNETI HKNFMRLELL MGTHKSHFAY
RLALENTTTE HIPFIALHRR DLVSADEGNR SFLGDGGRIN WRKFQIMGDI LLTLTNSQSM
PHRDLRPNPM TNQLISDATG TMKDEQLMEG FQELYERSVH LEPSNNPADV QRAKRGWFKR
//
