ID S8ADG8_DACHA Unreviewed; 608 AA.
AC S8ADG8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=MPN domain-containing protein {ECO:0000259|PROSITE:PS50249};
GN ORFNames=H072_7065 {ECO:0000313|EMBL:EPS39146.1};
OS Dactylellina haptotyla (strain CBS 200.50) (Nematode-trapping fungus)
OS (Monacrosporium haptotylum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Orbiliomycetes;
OC Orbiliales; Orbiliaceae; Dactylellina.
OX NCBI_TaxID=1284197 {ECO:0000313|EMBL:EPS39146.1, ECO:0000313|Proteomes:UP000015100};
RN [1] {ECO:0000313|EMBL:EPS39146.1, ECO:0000313|Proteomes:UP000015100}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 200.50 {ECO:0000313|EMBL:EPS39146.1,
RC ECO:0000313|Proteomes:UP000015100};
RX PubMed=24244185;
RA Meerupati T., Andersson K.M., Friman E., Kumar D., Tunlid A., Ahren D.;
RT "Genomic mechanisms accounting for the adaptation to parasitism in
RT nematode-trapping fungi.";
RL PLoS Genet. 9:E1003909-E1003909(2013).
RN [2] {ECO:0000313|Proteomes:UP000015100}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 200.50 {ECO:0000313|Proteomes:UP000015100};
RA Ahren D.G.;
RT "Genomic mechanisms accounting for the adaptation to parasitism in
RT nematode-trapping fungi.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M67C family.
CC {ECO:0000256|ARBA:ARBA00010981}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPS39146.1}.
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DR EMBL; AQGS01000487; EPS39146.1; -; Genomic_DNA.
DR RefSeq; XP_011112838.1; XM_011114536.1.
DR AlphaFoldDB; S8ADG8; -.
DR STRING; 1284197.S8ADG8; -.
DR MEROPS; M67.A14; -.
DR eggNOG; KOG2880; Eukaryota.
DR HOGENOM; CLU_023304_4_0_1; -.
DR OMA; SWGVFRL; -.
DR OrthoDB; 5490729at2759; -.
DR Proteomes; UP000015100; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0061578; F:K63-linked deubiquitinase activity; IEA:InterPro.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR CDD; cd08066; MPN_AMSH_like; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR044098; STAMBP/STALP-like_MPN.
DR InterPro; IPR015063; USP8_dimer.
DR PANTHER; PTHR12947; AMSH-LIKE PROTEASE; 1.
DR PANTHER; PTHR12947:SF13; FI19924P1; 1.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF08969; USP8_dimer; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR SUPFAM; SSF102712; JAB1/MPN domain; 1.
DR SUPFAM; SSF140856; USP8 N-terminal domain-like; 1.
DR PROSITE; PS50249; MPN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015100};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 432..560
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
FT REGION 138..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..296
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 608 AA; 69680 MW; 6EBD8511B6547D6C CRC64;
MSRTVFHASS AGPPVPSKDI SKRALDYEYS DQIQLATWLR TAATLIREAD VYYKEGNEEQ
AFLLYMRHMD LIVTHLPSHP QARESRYEKQ LVAMNEKFPA IASRMEKLKT NINTRYEAYA
RERQRQAQKE LEEKQALLRQ HRRSRGSSIS SSNGSTSQYT YGQMVDGRGS YFPDQGRGRP
GELEKMGRRL SMQTSVSSNT SPSLHPAFTP REHFEEHGWN YEPAIPTPTE SNKRISWKKP
QDEEFDLQKR LQDLHLRTQT PVPLALQPGQ GRRDDKDKER ERDKEREKEK ERLKGPRPMS
LQYPPLAEGK ARMEYPLVPK RTPYTPIQTQ MPNIDDFANP AKLEQYRQSI DRMPIVPPKI
KDEYDPNYIS PQTTAPPPRP LKERTQSMTS TPTTSFQAKP GAMEPPEKPK RTEANHIFDC
VAYTEGGKSL RTIFIPRDLR KTFLAVAAPN TKRNLETCGI LAGFLRNNAF FVNRLVIPQQ
EATSDTCNMM DESSLFDYID SEDLMVLGWI HTHPSQTCFM SSVDLHTHCG YQMMLRESIA
IVCAPSSNPS WGVFRLTDPD GVRAIKNCNN TGLFHPHSSP HVYTDALRPG HVCEVDKLQF
KIHDLRTS
//
