ID S8EAN5_9LAMI Unreviewed; 664 AA.
AC S8EAN5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
DE Flags: Fragment;
GN ORFNames=M569_01828 {ECO:0000313|EMBL:EPS72923.1};
OS Genlisea aurea.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Lentibulariaceae; Genlisea.
OX NCBI_TaxID=192259 {ECO:0000313|EMBL:EPS72923.1, ECO:0000313|Proteomes:UP000015453};
RN [1] {ECO:0000313|EMBL:EPS72923.1, ECO:0000313|Proteomes:UP000015453}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23855885;
RA Leushkin E.V., Sutormin R.A., Nabieva E.R., Penin A.A., Kondrashov A.S.,
RA Logacheva M.D.;
RT "The miniature genome of a carnivorous plant Genlisea aurea contains a low
RT number of genes and short non-coding sequences.";
RL BMC Genomics 14:476-476(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPS72923.1}.
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DR EMBL; AUSU01000641; EPS72923.1; -; Genomic_DNA.
DR AlphaFoldDB; S8EAN5; -.
DR OrthoDB; 1330770at2759; -.
DR Proteomes; UP000015453; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 2.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000015453};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 633..657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..69
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
FT DOMAIN 95..200
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EPS72923.1"
SQ SEQUENCE 664 AA; 71342 MW; 90711D6C4067596E CRC64;
FESVPDLEKS MYVPIEGFPC VRLLNLSGEI GCSNPGRSSV VAPVVRLKDV EDLVGSAAIL
VSLEEFETII GRHCFSFFLL GGKKKKSSSY SPSFTFSRFS NSSFYSKVAG ILVKSGARDQ
NGLNGFSPDI KFPQAELAPY KSNFQWNPAG SGIMRNAYDF PVFLLSKAST TVLEEVATAN
ENGRKFRGEV VAEFDIVMQT TKSGTRDSDS CLKEGTCLPL GGYSVWSALP PINPSSSSNV
KPLIMTMASM DSASFFRDQS LGAESPISGL IALLAVVDSL SRLGGLDKLN KQFVFVVFTG
EAWGYLGSRR FFLESEQMSA AMKGLDLAAI ETIIEIGSVG KSSPTERTFF AHTTGDASSL
NGTLRAFQNA QSSSVADERI NIKAASKTNP GIPPSSLMTF LSKNPNASGV VVEDFDYAFS
DAFYHSHLDD SSNINSSSIV AAATLVARTL YILAGGEETP SSVMNINATL VEELVGCLLD
CDPGLSCDLA KHYISPSSAA TCPNNYVGVV LGDPSDPTAP YAGDVSRLVW NFMAEKASVP
SKNATSSSCP DECRGEGESC IRKEPDGRGV CVVSTTRYVP AYSTRLKYES GSWTVLPPNV
SDRLGSEDPV WTESNWDAIQ VRVYKVQNGS YDAFILVSGI VVTVLSYVLV IISRAVIRKA
VKRD
//
