ID S9QID5_9RHOB Unreviewed; 190 AA.
AC S9QID5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=HTH-type transcriptional regulator BetI {ECO:0000256|HAMAP-Rule:MF_00768};
GN Name=betI {ECO:0000256|HAMAP-Rule:MF_00768};
GN ORFNames=thalar_00666 {ECO:0000313|EMBL:EPX81216.1};
OS Litoreibacter arenae DSM 19593.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Litoreibacter.
OX NCBI_TaxID=1123360 {ECO:0000313|EMBL:EPX81216.1, ECO:0000313|Proteomes:UP000015351};
RN [1] {ECO:0000313|Proteomes:UP000015351}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19593 {ECO:0000313|Proteomes:UP000015351};
RX PubMed=24501650; DOI=10.4056/sigs.4258318;
RA Riedel T., Fiebig A., Petersen J., Gronow S., Kyrpides N.C., Goker M.,
RA Klenk H.P.;
RT "Genome sequence of the Litoreibacter arenae type strain (DSM 19593(T)), a
RT member of the Roseobacter clade isolated from sea sand.";
RL Stand. Genomic Sci. 9:117-127(2013).
CC -!- FUNCTION: Repressor involved in choline regulation of the bet genes.
CC {ECO:0000256|HAMAP-Rule:MF_00768}.
CC -!- FUNCTION: Repressor involved in the biosynthesis of the osmoprotectant
CC glycine betaine. It represses transcription of the choline transporter
CC BetT and the genes of BetAB involved in the synthesis of glycine
CC betaine. {ECO:0000256|ARBA:ARBA00024936}.
CC -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC choline pathway [regulation]. {ECO:0000256|ARBA:ARBA00004719,
CC ECO:0000256|HAMAP-Rule:MF_00768}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPX81216.1}.
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DR EMBL; AONI01000006; EPX81216.1; -; Genomic_DNA.
DR RefSeq; WP_021101735.1; NZ_KE557312.1.
DR AlphaFoldDB; S9QID5; -.
DR STRING; 1123360.thalar_00666; -.
DR PATRIC; fig|1123360.3.peg.658; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_069356_15_4_5; -.
DR OrthoDB; 7618612at2; -.
DR UniPathway; UPA00529; -.
DR Proteomes; UP000015351; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR HAMAP; MF_00768; HTH_type_BetI; 1.
DR InterPro; IPR039538; BetI_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR InterPro; IPR017757; Tscrpt_rep_BetI.
DR NCBIfam; TIGR03384; betaine_BetI; 1.
DR PANTHER; PTHR30055:SF254; HTH-TYPE TRANSCRIPTIONAL REGULATOR BETI; 1.
DR PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR Pfam; PF13977; TetR_C_6; 1.
DR Pfam; PF00440; TetR_N; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_00768, ECO:0000256|PROSITE-
KW ProRule:PRU00335}; Reference proteome {ECO:0000313|Proteomes:UP000015351};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00768};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00768};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00768}.
FT DOMAIN 8..68
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 31..50
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00768,
FT ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 190 AA; 20703 MW; DFE5B005D3091917 CRC64;
MPKLGMEPIR REALVTAAIA EIGAAGSLDV TVSAISKRAG MSSALAHHYF GNKDQIFLAA
MRHILAGFAV EVRSRLSMAD TPRDRLTALV EASFAQSCFD PEVISAWLNF YVKAHSSPDA
MRLLRVYQHR LRSNLIHTLR PIAREPEALA DTIAALIDGL YIRAALGAVK TNDPASAILA
FTAPHLEDER
//
