ID S9TXM0_9TRYP Unreviewed; 618 AA.
AC S9TXM0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 22-FEB-2023, entry version 31.
DE SubName: Full=Elongation factor 1 alpha-like protein {ECO:0000313|EMBL:EPY21388.1};
GN ORFNames=STCU_08568 {ECO:0000313|EMBL:EPY21388.1};
OS Strigomonas culicis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Strigomonadinae; Strigomonas.
OX NCBI_TaxID=28005 {ECO:0000313|EMBL:EPY21388.1, ECO:0000313|Proteomes:UP000015354};
RN [1] {ECO:0000313|EMBL:EPY21388.1, ECO:0000313|Proteomes:UP000015354}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23560078;
RA Motta M.C., Martins A.C., de Souza S.S., Catta-Preta C.M., Silva R.,
RA Klein C.C., de Almeida L.G., de Lima Cunha O., Ciapina L.P., Brocchi M.,
RA Colabardini A.C., de Araujo Lima B., Machado C.R., de Almeida Soares C.M.,
RA Probst C.M., de Menezes C.B., Thompson C.E., Bartholomeu D.C., Gradia D.F.,
RA Pavoni D.P., Grisard E.C., Fantinatti-Garboggini F., Marchini F.K.,
RA Rodrigues-Luiz G.F., Wagner G., Goldman G.H., Fietto J.L., Elias M.C.,
RA Goldman M.H., Sagot M.F., Pereira M., Stoco P.H., de Mendonca-Neto R.P.,
RA Teixeira S.M., Maciel T.E., de Oliveira Mendes T.A., Urmenyi T.P.,
RA de Souza W., Schenkman S., de Vasconcelos A.T.;
RT "Predicting the Proteins of Angomonas deanei, Strigomonas culicis and Their
RT Respective Endosymbionts Reveals New Aspects of the Trypanosomatidae
RT Family.";
RL PLoS ONE 8:E60209-E60209(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPY21388.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ATMH01008568; EPY21388.1; -; Genomic_DNA.
DR AlphaFoldDB; S9TXM0; -.
DR EnsemblProtists; EPY21388; EPY21388; STCU_08568.
DR OrthoDB; 125722at2759; -.
DR Proteomes; UP000015354; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR CDD; cd04093; HBS1_C_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR PANTHER; PTHR23115:SF295; FACTOR 1-ALPHA, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:EPY21388.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:EPY21388.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000015354}.
FT DOMAIN 196..417
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 17..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 618 AA; 67840 MW; E829C3B227132EDC CRC64;
MNRHQKFFAE LEHTLDEEEY YDEEDYEEEY EEEYYNEEGE EYYDPEAAAA EARHAKVVNP
HTCISPEVDA DFELLDAMLP VLHQEWKEKA PRELPLMEIA AVEALRHAEY DVNSAVDYAL
ERRLEGKKGQ VKKALHVTGC ASKHDESQRS NTEAATNDVS EAQGPSTLAL GTSANAPKKS
TKRAKGLEGL MPDASKPDCT FVIAGHVDSG KSTTLGHLLL LLGKVSMEDV SRNEQEAHGT
NKESFKYAWL LDQSEEERRR GVTIDSGSQC FETAHRRVHI LDAPGHKDYV LSMMSSATQA
DAALLVINAS TSEFETGFAH GTRDHLLVLK TLGIGSIIVA VNKMDSVNYS KDRYNYIIQQ
LKLLFKELRI KESCIVGYCP VSGMSGVNLC ELMPLQTPWY DGPCLIDLLD RCPLESRLLE
APLRLSLQDV QGSSLYAKVE SGKLLKGDTL HFVPCDVKVA VRQIVKPTVG GVVQAAFAGE
PVEISTNSNL VGLYPGCVGS LQGESACRAA RRFEAHVQTF PTLQKAVIPG ASFMMVAHAL
TVPVKVTLLV SKMKPSDGSW SKGMVKCVPA GAQAIVQLQA EQKVALENSE DCRALGRFIL
QQDGETVAGG LVKNVIVD
//
