ID S9UAA4_9TRYP Unreviewed; 3047 AA.
AC S9UAA4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Dynein heavy chain, axonemal {ECO:0000313|EMBL:EPY25664.1};
GN ORFNames=STCU_06579 {ECO:0000313|EMBL:EPY25664.1};
OS Strigomonas culicis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Strigomonadinae; Strigomonas.
OX NCBI_TaxID=28005 {ECO:0000313|EMBL:EPY25664.1, ECO:0000313|Proteomes:UP000015354};
RN [1] {ECO:0000313|EMBL:EPY25664.1, ECO:0000313|Proteomes:UP000015354}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23560078;
RA Motta M.C., Martins A.C., de Souza S.S., Catta-Preta C.M., Silva R.,
RA Klein C.C., de Almeida L.G., de Lima Cunha O., Ciapina L.P., Brocchi M.,
RA Colabardini A.C., de Araujo Lima B., Machado C.R., de Almeida Soares C.M.,
RA Probst C.M., de Menezes C.B., Thompson C.E., Bartholomeu D.C., Gradia D.F.,
RA Pavoni D.P., Grisard E.C., Fantinatti-Garboggini F., Marchini F.K.,
RA Rodrigues-Luiz G.F., Wagner G., Goldman G.H., Fietto J.L., Elias M.C.,
RA Goldman M.H., Sagot M.F., Pereira M., Stoco P.H., de Mendonca-Neto R.P.,
RA Teixeira S.M., Maciel T.E., de Oliveira Mendes T.A., Urmenyi T.P.,
RA de Souza W., Schenkman S., de Vasconcelos A.T.;
RT "Predicting the Proteins of Angomonas deanei, Strigomonas culicis and Their
RT Respective Endosymbionts Reveals New Aspects of the Trypanosomatidae
RT Family.";
RL PLoS ONE 8:E60209-E60209(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPY25664.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ATMH01006579; EPY25664.1; -; Genomic_DNA.
DR EnsemblProtists; EPY25664; EPY25664; STCU_06579.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000015354; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000015354}.
FT DOMAIN 205..611
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 739..1065
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1233..1362
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 1583..1678
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 1735..1995
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2008..2354
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 2383..2603
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 2849..2961
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 2993..3047
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT COILED 2003..2108
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2239..2301
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2593..2623
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3047 AA; 348730 MW; 1159E3C60E42A4A5 CRC64;
MVDCRRRLSS KCGKVVSRIL DVMASRALDK EKEIHENFCD IHDTLTKPVN TPEEVVATKD
YIKTIPEKVF ELQMVIQEVR EIHDVLDFFH RGLSDDEFDK KWRTVAWPSQ LDDTINTRTL
ELEEVKRSLV GTMNRSQEQF DSDVTFAQKV VETYGQHCSL ARASETATDV RNVLQQIQQL
REKANTFNTH ESLFNLEKTD YNAVHQLSTD FEPYASLWLT IDHWTTSLKG WQEAVFSTID
AEDMEQQVVE DYKVIGKCCR STLLSPDLIE IAESVRAQIE EFKPTVPVVK CLRTEGMKER
HWEQLSKETG KEVNPLTTLT SLADVETLGL MSSETTVQRI TEIAAREYQI EMALVRMNTV
WEGLRLNAKS YKETGCYILG KDVIDDTQET LDDQVLTTQS LLFSPFKKLF EADISNWEAS
LTLVQNVLDE WLKCQKSWLY LEPIFQSEDI ARQLPAEDKR FQQVNKNWKF LTASAHTIDL
IMPFCTQTEK CLELLKENND LLEMVEKGLN QYLESKRASF ARFYFLSDDE LLTILSEARD
PQKIQPQFRK LFENIAKIDM RLPDNEMFGM YSQMNEYIPF IQSVAPRKYV ESWLTEIESM
MKLSIRAQLE KGVTDFKTMD REAFILQSPG QVAIAVNQIM WTYECETTLK EHGSLAPYAP
TAMKNLMVLV ETVRKPLSNL QRMNLSGLIT IEVHARDIVE QLAKDGVDSV FAFEWVSQLR
SYWENNDCFL RQVEAQFRYG GEYLGNTTRL VITPLTDRIY LTLTGAMHMF LGGAPAGPAG
TGKTETVKDL AKAVAKQCVV FNCQEGMTFA SMGKFFKGLA QAGAWACFDE FNRIDVEVLS
VVSQQVSSLQ EAARTRQYRI PFEGTEIVVD PSYSVFITMN PGYAGRTELP DNLKVLFRPV
ACMVPDYAMI AEIRLFSFGY AESRKLAQKM VATFRLSSEQ LSSQDHYDFG MRAVNTVISA
AGLMKREHPE EAEDVLLLRA LRDSNAPKFL DEDLLLFDGI ISDLFPGLQL SPSDYGDFVV
VMRETAQEMN LQPTTMFIKK CVELYEMSVL RHGQMSVGPT MGGKTSATRV LQATMTKMRT
EKENERFAVV KTYSLNPKSI TMAQLYGGFD DVTGEWREGL VGELFRTAAR DTTDARHLIV
FDGPVDALWI ESMNTVLDDN KKLCLISGEI IAMTPYMCCW FEVEDLAVAS PATVSRAGMI
YFLPDTCIGV SNFIKSWQMY ELPSTLEPYK EGLQELCERL FPSLIQFVQT QVTEYSPSVW
PNLVTSCFKI FSCFMEPYTP TRTYDVSQEM LDMLRENYLH ILVFSIVWSF GVTGDRPSRQ
KFDKFLRDEL RLRGVNIELP VIGCLLDYQF VPEERAWVSW TERLPPFAEH VTTANMADII
VPTADVVRYK FINRLLLTNS YHTLCCGPTG TGKSVLLEQL LMSEMPKQFT PIFFTFSART
SANQTQDLIF SKLEVRRRAT PQIWGAPLNK KFVVKIDDMN MPMKEQYGAQ PPIEILRQFM
DYGGWYDRKT REFFNIVDVI YVAAMGPPGG GRNQVSNRFL RHFNQIAFPE IDDDSMKRIY
LSLLESYFSD FPEDIRGKVS TIVTASIDVF NTVSKELRPT PARPHYLFNL RDLSKVMGGV
IYAKHNTVTS VHALARLWIH EEKRTFADRL VSTKDNEWFD ALLQKQITKQ FKLAYDEVMP
PQSEDSPCKE LLFCDFVGPK TDQRTYTEVT DFNSLVKTLE KQIEEYNSQS VSNHLNLVMF
ADAVQHVCRI SRVLGKPNGH VLLLGVGGSG RQSLSRLAAH LSELDLKQVE ISKGYTVNAW
REDIKAVLRL VAFKNKQVLF LFSDTQIVFE SMLEDVNNLL NSGEVPNLFL GTEFDDLLNA
MKPICLAENI PLDKVSVFGR FVRGCRVNLH ISLCMSPLGE VFRSRLRMFP SLVNCCTIDW
FSAWPHQALR SVAKQNFSDF ELLTTSEEIE ACTEVCVDMH LSVEEFSKRF LEECHRYNYV
TPTSFLELLR TFRELLTQQT TANNQTKNRL QNGLKKLKET EDAVAGLQQT LAENQPILLE
KNEAIKKLVA EMDVQTKSAE ETKREAEREQ TAVAAKQAEC AGIEAEAQEQ LSEALPELDR
ALESLKNLKS AQITEVSGYK APTPGVIMTM QGICILFQIK PLMKAASAME EKKADYWATA
REQLLSNPNQ LLQKLFNFDK EHIPEKLIQQ VMPLVSSEDF TPKRIAGASQ ACAAMCQWTH
AMVRFHQVNK KVEPLRARLA IAQAANHEAQ TKLQAAEARL EQVARSLEEM QRKKESAEEE
MKELDATVKN TELKLERAAM LIDGLAGEKK NWLKTIEDIT EKLKFVTGDM LVAAGQVAYC
GPFIASYRRD LLLKWRDTLS QRSMLHSDQL SVFHSLQDPV QTREWGINGL PQDLLSVENA
LFLTNARRWP LMIDPQTQAN KWIKQTYKDS LEVLKPSQRD LVKRIEYCIR AGRSVLLENV
SEDIDASLNP LLGRQTFFQG GTEMIRISDT AIPWNDKFKF FMTTKLPNPH YTPEVMVRVT
LLNFFITPQG LEDQLLGVVV GQERKELETR RSDLIQKNAS MKADLANIQK TILRKLEEVK
GDVLDDVELI AYLNESKEKT VEITTKVAEA EEAEKEINDT REEYRPVARH AACLYFCCST
LSSVDPMYQY SLQWFVQLFI AGIDQSARAD ELEKRLQNLN EYFTYSFYQN VSRSLFEKHK
LMFSFFLCIR ILQQDNGVNE TEFRFLLQGP TVTEKATDNP DPSWIVASTW NDLCYLAKHF
KCFNNFIEHF KSNLKAYQEL FMSSNAHTLP LPDGWTEKIT PMQHMLFLRC LRPDKLMEAV
QIYVTQQMGE QFIRPPQFDL LTSYKDATAT TPLIFILSQG ADPYEDWKKF AETQQMSKKL
YDISLGQGQG PRAERMLQEG MENGAWVLLQ NCHLATSWMP SLERVVESMT SAVHPKFRLW
LTSMPSPHFP VAVLQNGVKM TNEPPKGMQA NVTRSILSYT NDYLETCKKT DAFKKLFFSF
TFFHALIQER RKFGPLGWNI AYEYTSGDLG CCVDQVKMFL DKYDEVP
//
