ID   S9UZ44_9TRYP            Unreviewed;       758 AA.
AC   S9UZ44;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=cAMP-specific phosphodiesterase {ECO:0000313|EMBL:EPY19911.1};
GN   ORFNames=STCU_09241 {ECO:0000313|EMBL:EPY19911.1};
OS   Strigomonas culicis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Strigomonadinae; Strigomonas.
OX   NCBI_TaxID=28005 {ECO:0000313|EMBL:EPY19911.1, ECO:0000313|Proteomes:UP000015354};
RN   [1] {ECO:0000313|EMBL:EPY19911.1, ECO:0000313|Proteomes:UP000015354}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23560078;
RA   Motta M.C., Martins A.C., de Souza S.S., Catta-Preta C.M., Silva R.,
RA   Klein C.C., de Almeida L.G., de Lima Cunha O., Ciapina L.P., Brocchi M.,
RA   Colabardini A.C., de Araujo Lima B., Machado C.R., de Almeida Soares C.M.,
RA   Probst C.M., de Menezes C.B., Thompson C.E., Bartholomeu D.C., Gradia D.F.,
RA   Pavoni D.P., Grisard E.C., Fantinatti-Garboggini F., Marchini F.K.,
RA   Rodrigues-Luiz G.F., Wagner G., Goldman G.H., Fietto J.L., Elias M.C.,
RA   Goldman M.H., Sagot M.F., Pereira M., Stoco P.H., de Mendonca-Neto R.P.,
RA   Teixeira S.M., Maciel T.E., de Oliveira Mendes T.A., Urmenyi T.P.,
RA   de Souza W., Schenkman S., de Vasconcelos A.T.;
RT   "Predicting the Proteins of Angomonas deanei, Strigomonas culicis and Their
RT   Respective Endosymbionts Reveals New Aspects of the Trypanosomatidae
RT   Family.";
RL   PLoS ONE 8:E60209-E60209(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EPY19911.1}.
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DR   EMBL; ATMH01009241; EPY19911.1; -; Genomic_DNA.
DR   AlphaFoldDB; S9UZ44; -.
DR   EnsemblProtists; EPY19911; EPY19911; STCU_09241.
DR   OrthoDB; 125826at2759; -.
DR   Proteomes; UP000015354; Unassembled WGS sequence.
DR   GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.1300.10; 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain; 1.
DR   InterPro; IPR002073; PDEase_catalytic_dom.
DR   InterPro; IPR036971; PDEase_catalytic_dom_sf.
DR   PANTHER; PTHR11347:SF222; CAMP-SPECIFIC PHOSPHODIESTERASE-RELATED; 1.
DR   PANTHER; PTHR11347; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; 1.
DR   Pfam; PF00233; PDEase_I; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51845; PDEASE_I_2; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015354}.
FT   DOMAIN          138..294
FT                   /note="PDEase"
FT                   /evidence="ECO:0000259|PROSITE:PS51845"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          117..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          690..758
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   758 AA;  83114 MW;  F59861E4BC116F25 CRC64;
     MSSQLPKITP GKPTKGAKTA PKPVSTLLNN SSPEETLRLL STDTSLPLYV QKSLQGIVDK
     MNSKKGVQSF YETSKHTPIQ VFLSDTITDG MPLRQSNLRM LHEHTRVHEF NICRSPSQHL
     SASPRTMGKR SAPAIQDPSN TFEKMNRIMM QTLRYIDSVT ELEFDIMDIR EHDGTIMNDS
     ERLFLSVTCS IFANFSLCTS LNIDLKKLLN FLTGIHTYYQ DENPYHNATH AADSLQMLSL
     LFREPSISFL FTDEEILLSF LCVLSMDVAH AGLTTTSLAA LNHPLVAVFG DTATQVHASL
     LVFLHELFRD ENFIFPDVTS NPNSMTIQLI RESLNAVVLN TVPRGRCFLM ARLHKISEEG
     SVKGEDMMYI MAALAVLAES AFALRPRKQC FGMGSKLLIE LQREAKEMTR KNVPSSVQQL
     SSCDPAEFIM ETCRLIVRPI ADAVSALITM DLLDNLERNT DADTFASERK LVPPPTQEGR
     ATAWIDNSSA VIDILKKATT HANSLDRKAS KRAILNASPP RTNAASAAAS MDPKAGTASM
     SLGSPICGNS LVNLGASLSE GDFSHSMRHS NRAEHYFSFL RLYNQCENEG ATSSDFFSRI
     IFLALQLDPS YVANYAKEKY GADGNAAQCG EMARFIMLNE EVPSTAEGIA SRVPGTNSFS
     VSEAGSSTDG FLLLLMDMYM EREAATAAQA VQADPPAAAE GVPQNWGGSD SGSTLAPSEP
     DTADPLMDFR PQRDSPIRLP VTTDGSSKVE FPAAPHHQ
//