ID S9V6R4_9TRYP Unreviewed; 1700 AA.
AC S9V6R4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN ORFNames=STCU_08194 {ECO:0000313|EMBL:EPY22636.1};
OS Strigomonas culicis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Strigomonadinae; Strigomonas.
OX NCBI_TaxID=28005 {ECO:0000313|EMBL:EPY22636.1, ECO:0000313|Proteomes:UP000015354};
RN [1] {ECO:0000313|EMBL:EPY22636.1, ECO:0000313|Proteomes:UP000015354}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23560078;
RA Motta M.C., Martins A.C., de Souza S.S., Catta-Preta C.M., Silva R.,
RA Klein C.C., de Almeida L.G., de Lima Cunha O., Ciapina L.P., Brocchi M.,
RA Colabardini A.C., de Araujo Lima B., Machado C.R., de Almeida Soares C.M.,
RA Probst C.M., de Menezes C.B., Thompson C.E., Bartholomeu D.C., Gradia D.F.,
RA Pavoni D.P., Grisard E.C., Fantinatti-Garboggini F., Marchini F.K.,
RA Rodrigues-Luiz G.F., Wagner G., Goldman G.H., Fietto J.L., Elias M.C.,
RA Goldman M.H., Sagot M.F., Pereira M., Stoco P.H., de Mendonca-Neto R.P.,
RA Teixeira S.M., Maciel T.E., de Oliveira Mendes T.A., Urmenyi T.P.,
RA de Souza W., Schenkman S., de Vasconcelos A.T.;
RT "Predicting the Proteins of Angomonas deanei, Strigomonas culicis and Their
RT Respective Endosymbionts Reveals New Aspects of the Trypanosomatidae
RT Family.";
RL PLoS ONE 8:E60209-E60209(2013).
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPY22636.1}.
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DR EMBL; ATMH01008194; EPY22636.1; -; Genomic_DNA.
DR EnsemblProtists; EPY22636; EPY22636; STCU_08194.
DR OrthoDB; 5474327at2759; -.
DR Proteomes; UP000015354; Unassembled WGS sequence.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF1; CLATHRIN HEAVY CHAIN; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 6.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 6.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000015354};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 338..356
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
FT REGION 1635..1700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1667..1688
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1700 AA; 190739 MW; 27420CDA55400A73 CRC64;
MANSPLGINE VFQLNSVNGG LRPGSVSFKN VTITSDKYVC VRDVQQEGQV SLVIVDLEKR
ESMRNNVRDA ESAVMNPAKK ILALRSGRNL QIFDVEASKR LKAVVFTDDV LYWSWVDEKT
VGIVTGTAVY HWDLEGAADG SPTRFFDRPA DYDAAVQVLS YKVDADKRWA VVCGVTRDAS
GAMVGKALLY SVDNAVARVM EGHAVTFIST ATPSDSRKSN IMCLAWNSPQ QGGQVMIMEL
PTASKSDITV PRRVYPVQIA QGDFPVALHV SERHKLLTGI TSRGKCFLMD VFTGTLLYEQ
QFTQAVIFSG AGDKRTGGVV MVNNQGAVVR VGPDDGSIIN YVKNRMQNAG LALRIAGTAN
LGGVDDLFRV QLDNCLRSGN VEEAIRVCLK APNNSLRTRE VLTRFLQLPQ QPGQAPAIST
YFKMALAEGS LNESESVELA RAVVPKGGVA YVKQQFDEGK LTASEELGDL VAQADPDMAM
KLFHSGSAHA KVVNVLLQRN ETQKAVEYCK RANYTPDWRV IMQNFVRVNP QDAVNLGVML
YRDLADKPVI DAGEMVDMFV SSQHTQQATE LLLEILRDHN GEDTMDLQTK LLEINLKYSH
PSVSEKIFAR NICQFYDGMK LAPLCERTGL HQRAIECYIT AQKQDPDLDN LANIRRCLQQ
AQTFNPEWLV EFFGKLNKED SLKCLSDLTE NARKNFKVMV QVATKYNDAL GAKELIDLFL
DKNLYDVLYY YLGAIVPYTR DPEVHFRYIE AAAEMGQMQE LERMTRESPC YDAERTKNYL
KNKKLTDLWP FINVCDQHDM IGEMVHYLVE TGNEACIEQF VTRRSPAKAP QVAKALIECN
VSEEFIKSVL NAVGSMCPVE ELVAATEEVG RLHLIKEWLE ERKNEKKTDR ALFTALAKIY
VDIGQRPEEF LASNDYYDAE VVGTYCESRN PNLAFVAYMK GHASVPLIDL CRRNGLYKQE
ARYLVREQNL ELWAEVLASD DADRRQLIDA VQQTALPESE VSEEVSTTVR AFMNANLTEE
LTSLLDQIVV HGRFRKNRFL ENLLIMSAVR ARKDRVMEYV TGLEDYDAKD IANIATGAGM
HDVAFVVYDK HGLHKEAAHV LLHDLNDVAR GRAYTQKVDQ PAVWSELGAH LVSVDEVHEG
IECLIKAKNA ELVQEVTSAA ERTNQYGDLI KYLTMARKYS KTKDNKIDTA LVITYAKTGR
LGELEEFLKE THNVKIAAIA DKCFADELYE SAKVLYSVGN NFAKLALTEV KLHNLAAAVE
AANKAKSTTT FKEVNLACIE AKEMKLASIC AVPVVLRAEE VSGMCNRYES RGLWEDLYNV
LKTAAGNQGA HMGVFTEMGV ILAKYRPEKL LEHINMYLKK LNTHKMLSVC EQYHHWVPLR
VLHVNNEDYL AAANCMMEHY ADAWDHEIFK DVINHLGSSD VVYVAIGFYL KTHPELLNDF
LTAVFKKVDP ERVMVEVRRR APIYIIRQYL QAAQERNAKN VNEALNTLYM EEEDFNALRH
SVETYNNFDA QELTAVLEKK EMFEFRRIAL LLHRRNKRFA HAIAVAKENK LYEEAIATAA
ESSDAEIVDD LLDFFAKDFP ECFAACLYTC YDLLEPASVL QKAWLYGRTE IAMPYLVQAI
QEFTGKVNRM ERSMTDAQSA AKDAARRAGP AAGGPGPLMI EQGTGVPPPN MMPPPQAMHM
PPPQQAHYGA PPQFGSGRPF
//
