ID S9V7L3_9TRYP Unreviewed; 933 AA.
AC S9V7L3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:EPY22946.1};
GN ORFNames=STCU_08013 {ECO:0000313|EMBL:EPY22946.1};
OS Strigomonas culicis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Strigomonadinae; Strigomonas.
OX NCBI_TaxID=28005 {ECO:0000313|EMBL:EPY22946.1, ECO:0000313|Proteomes:UP000015354};
RN [1] {ECO:0000313|EMBL:EPY22946.1, ECO:0000313|Proteomes:UP000015354}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23560078;
RA Motta M.C., Martins A.C., de Souza S.S., Catta-Preta C.M., Silva R.,
RA Klein C.C., de Almeida L.G., de Lima Cunha O., Ciapina L.P., Brocchi M.,
RA Colabardini A.C., de Araujo Lima B., Machado C.R., de Almeida Soares C.M.,
RA Probst C.M., de Menezes C.B., Thompson C.E., Bartholomeu D.C., Gradia D.F.,
RA Pavoni D.P., Grisard E.C., Fantinatti-Garboggini F., Marchini F.K.,
RA Rodrigues-Luiz G.F., Wagner G., Goldman G.H., Fietto J.L., Elias M.C.,
RA Goldman M.H., Sagot M.F., Pereira M., Stoco P.H., de Mendonca-Neto R.P.,
RA Teixeira S.M., Maciel T.E., de Oliveira Mendes T.A., Urmenyi T.P.,
RA de Souza W., Schenkman S., de Vasconcelos A.T.;
RT "Predicting the Proteins of Angomonas deanei, Strigomonas culicis and Their
RT Respective Endosymbionts Reveals New Aspects of the Trypanosomatidae
RT Family.";
RL PLoS ONE 8:E60209-E60209(2013).
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPY22946.1}.
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DR EMBL; ATMH01008013; EPY22946.1; -; Genomic_DNA.
DR AlphaFoldDB; S9V7L3; -.
DR EnsemblProtists; EPY22946; EPY22946; STCU_08013.
DR OrthoDB; 622692at2759; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000015354; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000015354}.
FT DOMAIN 426..609
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 614..679
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 933 AA; 102821 MW; DB46B46B66C45452 CRC64;
MERAKLLYSH LQTNNYVRTE RHGAFFIIQL LNHAYGPAVG GALSSFRRVA LLGALREAEA
INDQLDAAAA APAAKNASER IRYVLLTSED PRIFSIGVNP ECFADGLYDT EAPGHLDERA
ATTAEQAAAE QGQLLRLLRA QGTAAEGVDA VDAAHVRVPS LRTLAQVIEN CSIPVVAAVQ
GICASWAVEL ILACHYRVAG GTARMRFPDV FLGLVPCGGG ALRLARLVGL RHAIDMLCTG
RKVGAAQAKR MGLVDAVVHV DAPPGAVGGM RSTFLRAVQQ LLVHSPSAQR HIAERMAVPP
SAKRAEGGRA PRVGFPVYNA ALFAWIKHRI HESASYEQRA PFFPLELMQL VCQHGHEPQV
YYAKEQTFVL SCLGSKEAKA SQHVMRGANG PLRQWLREHH RDALTASLLP SPQFTYSQPV
PSLRSIVIIG AGTMGTSIAM TLLHHLPHKH VTFVEIDESR QRIAQQGIRD YLDLSMYEGR
MTALERQHIL ARLRFAGSGE DPLPRAALSE ADLVIECTPE VTALKERIFA NIDPICKPSC
VFATGMSTRL LHELAQLTSR PSRFLGLHFY PPANETPLVE IASSSATDPA VMRYMVELML
RIHKHPIITC DRPGYGGARM LRAGLYQAYA MVEDGSFPYE VDRTLKKVFH FRFGIFELED
LVGLDVNALA RHSYFQQQRL SADSGAMPEV VTEVLRRAQL PPVAAAAPLP HRAAGQLPPR
DVFTVADELV KRGRLGRKSG EGWYRYAYNP LFALHRRAQR AEPPLPPPAA EGGAAAPPAR
SSFAFFTSDM VDTRSRHALL SIREMQVVHN REVEFLVLAN SKRKSIMRRD IADKELVERI
LLVMINEAAQ LLSEHYVKAA TDVDCLTVFG FGFPAWKGGL LYYADRVWGI AKVVTLMKMY
HRALSAATFP WPCSVLLEME ACGDTFASRF PQK
//
