ID S9VX13_SCHCR Unreviewed; 314 AA.
AC S9VX13;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Target of rapamycin complex subunit LST8 {ECO:0000256|ARBA:ARBA00018867};
GN ORFNames=SPOG_04864 {ECO:0000313|EMBL:EPY52208.1};
OS Schizosaccharomyces cryophilus (strain OY26 / ATCC MYA-4695 / CBS 11777 /
OS NBRC 106824 / NRRL Y48691) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=653667 {ECO:0000313|EMBL:EPY52208.1, ECO:0000313|Proteomes:UP000015464};
RN [1] {ECO:0000313|EMBL:EPY52208.1, ECO:0000313|Proteomes:UP000015464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OY26 / ATCC MYA-4695 / CBS 11777 / NBRC 106824 / NRRL Y48691
RC {ECO:0000313|Proteomes:UP000015464};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- SIMILARITY: Belongs to the WD repeat LST8 family.
CC {ECO:0000256|ARBA:ARBA00009890}.
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DR EMBL; KE546990; EPY52208.1; -; Genomic_DNA.
DR RefSeq; XP_013023590.1; XM_013168136.1.
DR AlphaFoldDB; S9VX13; -.
DR STRING; 653667.S9VX13; -.
DR EnsemblFungi; EPY52208; EPY52208; SPOG_04864.
DR GeneID; 25039177; -.
DR eggNOG; KOG0315; Eukaryota.
DR HOGENOM; CLU_000288_57_5_1; -.
DR OMA; VQRNYKH; -.
DR OrthoDB; 650241at2759; -.
DR Proteomes; UP000015464; Unassembled WGS sequence.
DR GO; GO:0010008; C:endosome membrane; IEA:EnsemblFungi.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR GO; GO:0000139; C:Golgi membrane; IEA:EnsemblFungi.
DR GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR GO; GO:0031931; C:TORC1 complex; IEA:EnsemblFungi.
DR GO; GO:0031932; C:TORC2 complex; IEA:EnsemblFungi.
DR GO; GO:0030950; P:establishment or maintenance of actin cytoskeleton polarity; IEA:EnsemblFungi.
DR GO; GO:0031505; P:fungal-type cell wall organization; IEA:EnsemblFungi.
DR GO; GO:0031930; P:mitochondria-nucleus signaling pathway; IEA:EnsemblFungi.
DR GO; GO:0001558; P:regulation of cell growth; IEA:EnsemblFungi.
DR GO; GO:0038202; P:TORC1 signaling; IEA:EnsemblFungi.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR037588; MLST8.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19842; G BETA-LIKE PROTEIN GBL; 1.
DR PANTHER; PTHR19842:SF0; TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015464};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 1..35
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 79..120
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 211..252
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 255..296
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 314 AA; 35119 MW; 9935E048CE4EA8C4 CRC64;
MSVQYPPQHS VLLVSSGYDH TIRFWEALSG ICSRTIQHAD TQVNRLCISP NKRFLAAAGN
PHVRLYDINS NSQLPLMTFE GHTNNVTAVA FHCDGKWLAT SSEDGTVKVW DMRAPSVQRN
YDHKSPVNDL LIHPNQGELI CCDQNGRVSA WDLGEDSCTH ELIPEEDVPM SSVTAASDGS
MLIAGNNKGN CYVWRMLNHQ GASLLQPVVK FQAHQRYITR CVLSPDVKHL ATCSADSTVN
IWSTDDMSFM LERRLQGHQR WVWDCAFSAD STYLVTASSD HVSRLWELSS GETIRQYSGH
HKAAVCVALN DYQI
//
