ID S9W1N9_SCHCR Unreviewed; 756 AA.
AC S9W1N9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=cysteine--tRNA ligase {ECO:0000256|ARBA:ARBA00012832};
DE EC=6.1.1.16 {ECO:0000256|ARBA:ARBA00012832};
DE AltName: Full=Cysteinyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00031499};
GN ORFNames=SPOG_00352 {ECO:0000313|EMBL:EPY51930.1};
OS Schizosaccharomyces cryophilus (strain OY26 / ATCC MYA-4695 / CBS 11777 /
OS NBRC 106824 / NRRL Y48691) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=653667 {ECO:0000313|EMBL:EPY51930.1, ECO:0000313|Proteomes:UP000015464};
RN [1] {ECO:0000313|EMBL:EPY51930.1, ECO:0000313|Proteomes:UP000015464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OY26 / ATCC MYA-4695 / CBS 11777 / NBRC 106824 / NRRL Y48691
RC {ECO:0000313|Proteomes:UP000015464};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR EMBL; KE546990; EPY51930.1; -; Genomic_DNA.
DR RefSeq; XP_013023315.1; XM_013167861.1.
DR AlphaFoldDB; S9W1N9; -.
DR STRING; 653667.S9W1N9; -.
DR EnsemblFungi; EPY51930; EPY51930; SPOG_00352.
DR GeneID; 25034684; -.
DR eggNOG; KOG2007; Eukaryota.
DR HOGENOM; CLU_013528_3_1_1; -.
DR OMA; YEGLGWA; -.
DR OrthoDB; 2140072at2759; -.
DR Proteomes; UP000015464; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR GO; GO:0005739; C:mitochondrion; IEA:EnsemblFungi.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004817; F:cysteine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006423; P:cysteinyl-tRNA aminoacylation; IEA:EnsemblFungi.
DR CDD; cd00672; CysRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR HAMAP; MF_00041; Cys_tRNA_synth; 1.
DR InterPro; IPR015803; Cys-tRNA-ligase.
DR InterPro; IPR024909; Cys-tRNA/MSH_ligase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR032678; tRNA-synt_1_cat_dom.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR NCBIfam; TIGR00435; cysS; 1.
DR PANTHER; PTHR10890:SF3; CYSTEINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR10890; CYSTEINYL-TRNA SYNTHETASE; 1.
DR Pfam; PF01406; tRNA-synt_1e; 1.
DR PRINTS; PR00983; TRNASYNTHCYS.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EPY51930.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000015464};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 38..454
FT /note="tRNA synthetases class I catalytic"
FT /evidence="ECO:0000259|Pfam:PF01406"
FT COILED 654..681
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 756 AA; 85953 MW; F88130CF4DBF6EFC CRC64;
MSSEKSQLSP WFAPTGHKTE LNVFNTITHS KVPFKTNGSM VTWYCCGPTV YDASHMGHAR
NYVTTDILRR ILQSYFGYNV TFVQNVTDID DKIILRARQQ YLFEQYKQQN EHNYASPTVK
AKVTEAWLAY AKKNLPESPQ SVDEWSNWLA THDITTLALA APKVPLYADS LTQGVEGLKI
AEEAKSEDSE LFWSKVQEVL IPVLDSELGN TVTDPAIFRK LSAYWENDYN EDMRALNVLP
PTTVTRVSEF VPEIVEYVQK IIDRGYAYPV TDGSVYFDTE AFSKGGHFYA KLEPWNKGNR
DLIAEGEGSL AALTGKKRPG DFALWKSSKP GEPSWDSPWS NGRPGWHIEC SVMASAVLGP
NVDIHSGGVD LAFPHHDNEL AQSEAYHDCP QWINYFLHTG HLHIEGQKMS KSLKNFITIK
EILKKFTPRQ LRLAFLLQQW NSQLDFKDAL LAHVLNVEQT LENFFQNVRA LNIESQGLSQ
QGGHVTEKYG ELERQLLNDL QTAQRNAHSA LCDNFNTPLV MFHIDSLVGK SNIYIRDVGQ
KPCTRLLNEI AMWITKMLQV FGLDDEGRPN AIGWSSKSSA SVSNSNDAIP YVRAVSTFRD
RIRELCIAKA PIQEILQACD VFRDYDMAEL GVSLNDRQQG PALIKLVDPQ VLIQARDQKI
AEEQEKEAKK LKAKAEQENK YIERIMKGKV APSEMFKLFE EFLSFDESGF PTKVRAEDGS
EVELPKSRKK KLQKEYTTQE KLHKEYLAYI EKKNQD
//
