ID S9W759_SCHCR Unreviewed; 979 AA.
AC S9W759;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=Exportin-T {ECO:0000256|ARBA:ARBA00018928, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=Exportin(tRNA) {ECO:0000256|RuleBase:RU366037};
DE AltName: Full=tRNA exportin {ECO:0000256|RuleBase:RU366037};
GN ORFNames=SPOG_03042 {ECO:0000313|EMBL:EPY53725.1};
OS Schizosaccharomyces cryophilus (strain OY26 / ATCC MYA-4695 / CBS 11777 /
OS NBRC 106824 / NRRL Y48691) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=653667 {ECO:0000313|EMBL:EPY53725.1, ECO:0000313|Proteomes:UP000015464};
RN [1] {ECO:0000313|EMBL:EPY53725.1, ECO:0000313|Proteomes:UP000015464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OY26 / ATCC MYA-4695 / CBS 11777 / NBRC 106824 / NRRL Y48691
RC {ECO:0000313|Proteomes:UP000015464};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex.
CC {ECO:0000256|RuleBase:RU366037}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU366037}. Nucleus
CC {ECO:0000256|RuleBase:RU366037}. Note=Shuttles between the nucleus and
CC the cytoplasm. {ECO:0000256|RuleBase:RU366037}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|ARBA:ARBA00009466, ECO:0000256|RuleBase:RU366037}.
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DR EMBL; KE546988; EPY53725.1; -; Genomic_DNA.
DR RefSeq; XP_013021155.1; XM_013165701.1.
DR AlphaFoldDB; S9W759; -.
DR STRING; 653667.S9W759; -.
DR EnsemblFungi; EPY53725; EPY53725; SPOG_03042.
DR GeneID; 25037361; -.
DR eggNOG; KOG2021; Eukaryota.
DR HOGENOM; CLU_004414_0_1_1; -.
DR OMA; HEMFLFG; -.
DR OrthoDB; 2546268at2759; -.
DR Proteomes; UP000015464; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952:SF11; EXPORTIN-T; 1.
DR PANTHER; PTHR15952; EXPORTIN-T/LOS1; 1.
DR Pfam; PF19282; Exportin-T; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU366037};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366037};
KW Reference proteome {ECO:0000313|Proteomes:UP000015464};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU366037};
KW Transport {ECO:0000256|RuleBase:RU366037};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555,
KW ECO:0000256|RuleBase:RU366037}.
FT DOMAIN 101..253
FT /note="Exportin-1/Importin-beta-like"
FT /evidence="ECO:0000259|Pfam:PF08389"
FT DOMAIN 322..973
FT /note="Exportin-T C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19282"
SQ SEQUENCE 979 AA; 110006 MW; FBE0739DDA19A844 CRC64;
MSAQDVEKAV EVALDPSVDV GIKQQATDFI STVRTSPEGW KVCQEIFVGK TAFKEASRLV
SLQILCEKAR EWKREVNGME LEMVKEHVWA YVKEQRFLDD PAYIINAIQH LLTLLFIQLY
PVMWNDFFQS LQSMAASSPQ VEPSEFYLKM LLSIGEEVAD SLIPKSTTQA QQSTAVKDAI
REKDMSEIVS FVFEMMVAYS NAKNYSPVVL SLQVFGQWVS WINISLIVNE PCMNLLYSFL
QIPELRCAAC ETITEIVNKK MKPLDKYNLL VLLNLNYFFT QFQEQSSDPT FDEHIAKLVN
AQGVELIAIK SDPTEMTPEA LENCSYQLYN LFPYLIRYLS DDYDETSSAV FPFLSDLLTS
LRKESSSKPL ADSSKHLLNS LLQALAKKMT YDESQEWDDD PESEEEAEFQ ELRKKLKTFQ
DTINLIDHSL YANFMYSVIT SSISSAAAMP IENSWQLVEF ALHETYIFGE GLRGPTAYVN
DADKSPSPLS QILLLVIESQ VGQHPHPLVQ LLYMEIIVRY SGFFEYQPSA IGPIMEYFVG
PTGIHNSNER VRVRAWYLFY RFVRSVTKYV ATYAESSLAL LGDLLNIDVQ PSTDIDSPEP
TLNSSIRNSS FNSQLYLFET AGILISSGTL PREEQVLFCD SLIDALLYKA NAALSGNASS
LESIISIYCS LMAIGNFAKG FPARDSQEIA WLSTFNKASD AIFSILNSMG FSEDIRSAVR
FASGRIINVV GPDMLPKVPQ LVSLLLSSIS LNELVDVLSF ISQLIYIYKE NMMGVISSLL
PSLLNTVFAS LSETPQGTDD AIKQSDLRKA YISFILHLLN KGFGSAFFSE QVQSYFDPLI
NSIIHFANLY GEPSTQKSSI ALLSKMVSLW GGPDGIEGFE RVIFGSLTPL CFEMPVNPVF
NANDGQSHIV LGELANLQRT ILEMCGEAYR SYLTGVYFPS VNFPEMLASE YLQVLVNSDS
RTFKQFFQKF IQAIKKGQA
//
