ID S9WBZ5_CAMFR Unreviewed; 1123 AA.
AC S9WBZ5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=DNA repair protein REV1 {ECO:0000256|PIRNR:PIRNR036573};
DE EC=2.7.7.- {ECO:0000256|PIRNR:PIRNR036573};
GN ORFNames=CB1_001577030 {ECO:0000313|EMBL:EPY75732.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY75732.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY75732.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- FUNCTION: Deoxycytidyl transferase involved in DNA repair. Transfers a
CC dCMP residue from dCTP to the 3'-end of a DNA primer in a template-
CC dependent reaction. May assist in the first step in the bypass of
CC abasic lesions by the insertion of a nucleotide opposite the lesion.
CC Required for normal induction of mutations by physical and chemical
CC agents. {ECO:0000256|PIRNR:PIRNR036573}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR036573}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|PIRNR:PIRNR036573}.
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DR EMBL; KB017732; EPY75732.1; -; Genomic_DNA.
DR AlphaFoldDB; S9WBZ5; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0042276; P:error-prone translesion synthesis; IEA:InterPro.
DR CDD; cd12145; Rev1_C; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 6.10.250.1490; -; 1.
DR Gene3D; 6.10.250.1630; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR Gene3D; 1.20.58.1280; DNA repair protein Rev1, C-terminal domain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR012112; REV1.
DR InterPro; IPR031991; Rev1_C.
DR InterPro; IPR038401; Rev1_C_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR45990; DNA REPAIR PROTEIN REV1; 1.
DR PANTHER; PTHR45990:SF1; DNA REPAIR PROTEIN REV1; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF21704; POLH-Rev1_HhH; 1.
DR Pfam; PF16727; REV1_C; 1.
DR PIRSF; PIRSF036573; REV1; 5.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|PIRNR:PIRNR036573};
KW DNA repair {ECO:0000256|PIRNR:PIRNR036573};
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634,
KW ECO:0000256|PIRNR:PIRNR036573};
KW DNA-binding {ECO:0000256|PIRNR:PIRNR036573};
KW Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR036573};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036573};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Transferase {ECO:0000256|PIRNR:PIRNR036573}.
FT DOMAIN 493..578
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT REGION 311..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 981..998
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1123 AA; 122923 MW; 4F5270717FDE6567 CRC64;
MQSHCPALGE TILLFIPAAV PCLWSVYPVG PLAGLSSLLA VLAFVASATP GAPGHKAAAK
TENAALRTVR ELSSPPWWEV AVHTDERLLA LGHSGARSST MRRGGWRKRA ENDGWENWGE
YMAAKVQKLE QQFRSDAALQ KDGTSSTIFS GVAIYVNGYT GTVNRDDGDG QCRFCDRKVI
SALDMNRRSI KAGRLLSYIP YQLYSKQSTV QRSLPFNPVC RPEDPAPGPS SVTRQLNDRV
NHIIKKIETE SEVRVGGVNN WKEEDAENDF GFVELEPIFP GRKQNRIMHP GDSSAICNGH
AHSSCNGALQ TQDCSAPPGH SGRLSPGPAE KHEPGVQQPP HSPGDTAALR SPHRTHPFSL
PPLHSNTKIN GAHHSSVPGP SSTKSTSSGP PLRRAAPSGQ PRPWDCSFIS DFYSRSRLHH
ISTWKCELTE FVNTLQRQSR KPVAVTSNRG TGRAPLRPGA NPQLEWQYYQ NKILKGKADT
DFIIMGSAED GTQVGIRNGM FFGQAKQLCP NLQAVPYDFH AYKEVARTMY ETLASYTHNI
EAVSCDEALV DITEILAETR LTPDEFASAV RTEIKDQTKW LRPVCPWPCA GRAWRSSTIA
ASSGGGKTEA EGLPRAPAAV YGVPLALASL VYGTSVPLGF SSPSPSQEAP GRASLRVSPV
GEGVGHSMES KLTSLGIKTC GDLQYMTMAK LQKEFGPKTG QMLYRFCRGL DDRPVRTEKE
RKSVSAEINY GIRFTQPKEA EAFLLSLSEE IQRRLEAAGV KGKRLTLKIM VRKPGAPAET
AKFGGHGICD TVTRTVTLGQ AADSAQVIGK AALNMFQTMK VNISDMRGHR HIKMPLEQTE
ERAADMGKPE FTFLKDDPGQ QTVCARTYVG IHVNQLAPAG PSPPARAARP SAQSGPVPGG
SHSILDLLQA QKAQKATEEE HKEALEIVSR GLVREGFLTA FADSSFNRAL PDTGPSVDPE
VFAALPAELQ KELKAAYDQR QRQGENPNPQ QQASTSDPME EDILQVVKYC TDLIEEKDLE
KLDLVIKYMK RLMQQSVESV WNMAFDFILD NVQVVLQQTY GSTLKVTREL HRADSGLAEL
AAQVCFFIGV QNCARYSDSR DYTSRRQQPA IVSHKAGKEY QNA
//
