ID S9WGV6_CAMFR Unreviewed; 1276 AA.
AC S9WGV6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Solute carrier family 12 member 1 isoform 2 {ECO:0000313|EMBL:EPY75638.1};
GN ORFNames=CB1_001602008 {ECO:0000313|EMBL:EPY75638.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY75638.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY75638.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR EMBL; KB017752; EPY75638.1; -; Genomic_DNA.
DR AlphaFoldDB; S9WGV6; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IEA:UniProt.
DR CDD; cd07557; trimeric_dUTPase; 1.
DR Gene3D; 2.70.40.10; -; 1.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR029054; dUTPase-like.
DR InterPro; IPR036157; dUTPase-like_sf.
DR InterPro; IPR033704; dUTPase_trimeric.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002445; Slc12a1.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF93; SOLUTE CARRIER FAMILY 12 MEMBER 1; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF00692; dUTPase; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01209; NAKCLTRSPRT2.
DR SUPFAM; SSF51283; dUTPase-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 567..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 90..157
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 211..631
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 640..1006
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 1125..1198
FT /note="dUTPase-like"
FT /evidence="ECO:0000259|Pfam:PF00692"
FT REGION 29..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1020..1039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1247..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 770..797
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 29..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1020..1035
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1255..1276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1276 AA; 141191 MW; 2D4451669FCD52A1 CRC64;
MSLNNSSNVF LDSMPSNTNR FQVNVISESH ESSAAVNDNT DPPHYEETSF GDEAQNRFRI
SFRPGNQQCY DSFLQNGETA KTDASFHAYD SHTNTYYLQT FGHNTVDAVP KIEYYRNTGS
ISGPKVNRPS LLEIHEQLAK NVAVAPGSAD LVANGDGIPG DEQAENKEED DQAGGVKFGW
VKGVLVRCML NIWGVMLFIR LSWIVGEAGI GGAYYLISRS LGPEFGGSIG LIFAFANAVA
VAMYVVGFAE TVVDLLKESD SMMVDPTNDI RIIGSITVVI LLGISVAGME WEAKAQVILL
IILLIAIANF FIGTVIPSNN EKRSRGFFNY QASIFAENFG PHFTKGEGFF SVFAIFFPAA
TGILAGANIS GDLEDPQDAI PKGTMLAIFI TTVAYIGVAI CVGACVVRDA TGSMNDTIIS
AMNCSGSAAC GLGYDFSRCR HEPCQYGLMN NFQVMSMVSG FGPLITAGIF SATLSSALAS
LVSAPKVFQA LCKDNIYKAL QFFAKGYGKN NEPLRGYFLT FVIAMAFILI AELNTIAPII
SNFFLASYAL INFSCFHASY AKSPVMFVIN WWAAVITYVI EFFLYIYVTY KKPDVNWGSS
TQALSYVSAL DNALGLTTVE DHVKNFRPQC IVLTGGPMTR PALLDITHAF TKNSGLCICC
EVFVGPRKLC VKEMNSGMAK KQAWLIKNKI KAFYAAVAAD CFRDGVRSLL QASGLGRMKP
NTLVIGYKKN WRKAPLTEIE NYVGIIHDAF DFEIGVVIVR ISQGFDISQV LQVQEELEKL
EQERLALEAT IKDNECEEGS GGIRGLFKKA SKLNITKPTA KKDNSINTIQ SMHVGEFNQK
LVEASTQFKK KQGKGTIDVW WLFDDGGLTL LIPYILTLRK KWKDCKLRIY VGGKINRIEE
EKIAMASLLS KFRIKFADIH IIGDINVKPN KESWKVFEEM IEPYRLHESC KDLTTAEKLK
RETPWKITDA ELEAVKEKSY RQVRLNELLQ EHSRAANLIV LHSPYPAPWS YLLQPGSGPY
RDEDHVREEE KETDGPQQLG AQWRGTSALR EEVWARPGEG AGQAVVGGKF RIFVPLLFRL
LLVALTFGAA MPCSQETRVV SPSKRPRPAA EEGGIRLRFA RLSEHATAPT KGSGRAAGYD
LYSAYDYTVP PMEKALVKTD IQIALPSGCY GRVAGVIDED YRGNVGVVLF NFGKEKFEGC
RFTLQGPKRQ RRNGQLWKSL GQRVTSPELS FRNIDINLMS ATVRLKGHRQ NSQVMGTEDG
RRKMDGNDTE KLQKQK
//
