ID S9WHJ5_CAMFR Unreviewed; 713 AA.
AC S9WHJ5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Interferon-induced GTP-binding protein Mx2 {ECO:0000256|ARBA:ARBA00039835};
DE AltName: Full=Myxovirus resistance protein 2 {ECO:0000256|ARBA:ARBA00042030};
GN ORFNames=CB1_001148001 {ECO:0000313|EMBL:EPY77962.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY77962.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY77962.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
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DR EMBL; KB017369; EPY77962.1; -; Genomic_DNA.
DR AlphaFoldDB; S9WHJ5; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR039477; ILEI/PANDER_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF46; INTERFERON-INDUCED GTP-BINDING PROTEIN MX2; 1.
DR Pfam; PF01031; Dynamin_M; 2.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 2.
DR Pfam; PF15711; ILEI; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU003932};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003932}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684}.
FT DOMAIN 222..495
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 608..713
FT /note="GED"
FT /evidence="ECO:0000259|PROSITE:PS51388"
SQ SEQUENCE 713 AA; 80696 MW; B61E384C3D802666 CRC64;
MSLSGLYLPL ICAQHAGLTK KPFDITFVIT GFKHHRDNFI FHKDEVQTPP EVVQASGTLK
AAFLVFASLC AWYSGYLLAE LIPAVPLSGT IYSIRSIGER PVLRAPAPKR QKCDHWTPCP
TNSYAYRLLS GGGRDKYAKI CFEDEILKED AKKAIEALGS KEIRNMRFRS SWVFLAAKGF
ELPAEIQREK GPENSLFSPY EERVRPCIDL VDSLRALGVE QDLALPAIAV IGDQSSGKSS
VLEALSGVAL PRGSGIVTRC PLVLQLKKQL HECTWRGTLS YRNTELQLQD PSQVEREIRK
AQDAIAGSGV GISHELISLE VTAPEVPDLT LIDLPGIARV AVGNQPQDIG QQIKALITKY
IRRQETINLV VVPCNVDIAT TEALSMAQEV DPDGDRTIGI LTKPDLVDKG TEKCVLNVMQ
NLTYCLKKGY MIVKCRGQQD ILDKMSLAEA TRRETLFFQM HPYFRGLLEE GKATVPRLAE
RLTAELTVHI RKSLPLLENQ IKESQQRAIE ELRQCGANVP SHDADKMFFL IEVALHVSVP
TVKNVIHEEV SRYEKQYRGK ELLGFVNYRT FETIVKQYLE RLVDPAVVML QKVVETVWHT
FTDTARKHFS EFSNLSQTAQ ETSKRLSNQI PLIIQYFMLQ ENGDHVQKAM MQTLQEKQQY
SWLLQAMMQT LQEKQQYSWL LQEQSDTSAK RRVLKEKIHR LDQARRALYQ FSL
//
