ID S9WPL9_CAMFR Unreviewed; 770 AA.
AC S9WPL9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Alpha-2-HS-glycoprotein {ECO:0000256|ARBA:ARBA00019375};
DE AltName: Full=DnaJ homolog subfamily B member 11 {ECO:0000256|ARBA:ARBA00039611};
DE AltName: Full=ER-associated DNAJ {ECO:0000256|ARBA:ARBA00041948};
DE AltName: Full=ER-associated Hsp40 co-chaperone {ECO:0000256|ARBA:ARBA00042329};
DE AltName: Full=Endoplasmic reticulum DNA J domain-containing protein 3 {ECO:0000256|ARBA:ARBA00041532};
DE AltName: Full=Fetuin-A {ECO:0000256|ARBA:ARBA00032001};
GN ORFNames=CB1_001118013 {ECO:0000313|EMBL:EPY78118.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY78118.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY78118.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC {ECO:0000256|ARBA:ARBA00004319}.
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DR EMBL; KB017341; EPY78118.1; -; Genomic_DNA.
DR AlphaFoldDB; S9WPL9; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR CDD; cd00042; CY; 2.
DR CDD; cd06257; DnaJ; 1.
DR CDD; cd10747; DnaJ_C; 1.
DR Gene3D; 3.10.450.10; -; 2.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 2.60.260.20; Urease metallochaperone UreE, N-terminal domain; 2.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR025760; Cystatin_Fetuin_A.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR002939; DnaJ_C.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR008971; HSP40/DnaJ_pept-bd.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR001363; Prot_inh_fetuin_CS.
DR PANTHER; PTHR44298; DNAJ HOMOLOG SUBFAMILY B MEMBER 11; 1.
DR PANTHER; PTHR44298:SF1; DNAJ HOMOLOG SUBFAMILY B MEMBER 11; 1.
DR Pfam; PF00031; Cystatin; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF01556; DnaJ_C; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00043; CY; 2.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF54403; Cystatin/monellin; 2.
DR SUPFAM; SSF49493; HSP40/DnaJ peptide-binding domain; 2.
DR PROSITE; PS51529; CYSTATIN_FETUIN_A; 2.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS01254; FETUIN_1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..770
FT /note="Alpha-2-HS-glycoprotein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004559288"
FT DOMAIN 25..90
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT DOMAIN 409..515
FT /note="Cystatin fetuin-A-type"
FT /evidence="ECO:0000259|PROSITE:PS51529"
FT DOMAIN 526..645
FT /note="Cystatin fetuin-A-type"
FT /evidence="ECO:0000259|PROSITE:PS51529"
SQ SEQUENCE 770 AA; 84732 MW; D938BDB2327BD416 CRC64;
MAPQNLGTFC LLLLYLIGAV IAGRDFYKIL GVPRSASIKD IKKAYRKLAL QLHPDRNPDD
PRAQEKFQDL GAAYEVLSDS EKRKQYDTYG EEGLKDGHQS SHGDIFSHFF GDFGFMFGGS
PRQQDRNIPR GSDIIVDLDV TLEEVYAGNF VEVVRNKPVA RQAPGKRKCN CRQEMRTTQL
GPGRFQMTQE VVCDECPNVK LVNEERTLEV EIEPGVRDGM EYPFIGEGEP HVDGEPGDLR
FRIKVVKHPI FERRGDDLYT NVTISLVESL VGFDMDITHL DGHKVHISRD KITRPGAKLW
KKGEGLPNFD NNNIKGSLII TFDVDFPKEQ LTEEAREAEF CLGSLNALLP QWRALLTSAG
DLVASSAAIL ELRHGPHGAP HSKLCPAPCC HLLELSGCLS VPHGPMPGYR EPACDDPETE
QAALVAVDYI NKRLLRGYKH TLNQIDSIRV WPRQPTGEVY EVEIDTLETT CHVRDPTPLA
NCSVRQMKEH AVEGDCDFHV LKQDGQLSVL SAKCDSSPDS AEDVHRVCPN CPLLAPLNDS
RVVHAVEVAL AASNAQSNGS YLQLVEISRA QFASCCFMNS FIYPHQPLQA AAVYVEFAVA
ATDCVAKDVT DPATCNLLAE KQYGFCRGTF IEKVGGGEDV TVTCTLFPTQ LSMKRVTLLV
KISHKPVIPQ PQPEAPTPVA EADALGLEPV VQPEPEPLEM IPPNPIPEPL NRAHYDLRHA
FAGVASVESS SGEAFHVGKT PKGVLPGIPA AGGLGPVIRP CPGRIRYFKI
//
