ID S9WSS7_CAMFR Unreviewed; 709 AA.
AC S9WSS7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN ORFNames=CB1_000950002 {ECO:0000313|EMBL:EPY79213.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY79213.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY79213.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}. Cell
CC projection, ruffle {ECO:0000256|ARBA:ARBA00004466}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Membrane raft
CC {ECO:0000256|ARBA:ARBA00035630}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00035630}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Recycling endosome
CC {ECO:0000256|ARBA:ARBA00004172}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR EMBL; KB017190; EPY79213.1; -; Genomic_DNA.
DR AlphaFoldDB; S9WSS7; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR Gene3D; 4.10.1240.30; -; 1.
DR Gene3D; 6.20.50.10; -; 1.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR040622; I-EGF_1.
DR InterPro; IPR015439; Integrin_b-2_sf.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF61; INTEGRIN BETA-1; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF18372; I-EGF_1; 1.
DR Pfam; PF08725; Integrin_b_cyt; 1.
DR Pfam; PF07965; Integrin_B_tail; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR PIRSF; PIRSF002512; Integrin_B; 2.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01241; Integrin_b_cyt; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Pyrrolidone carboxylic acid {ECO:0000256|ARBA:ARBA00023283};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 640..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..375
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 551..639
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT DOMAIN 663..709
FT /note="Integrin beta subunit cytoplasmic"
FT /evidence="ECO:0000259|SMART:SM01241"
FT REGION 16..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 150..156
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 204..244
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 346..602
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 373..377
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 388..400
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 397..436
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 402..411
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 413..427
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 442..447
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 444..479
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 449..464
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 466..471
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 485..490
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 487..518
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 492..501
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 503..510
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 524..529
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 526..572
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 531..541
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 544..547
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 551..560
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 557..634
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 576..610
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 709 AA; 78219 MW; 868F764684D4295B CRC64;
MPTSARCDDL EALKKKGCHP DDIENPRGSK DIKKNKNVTN RSKGTAEKLQ PEDITQIQPQ
QLVLQLRSGE PQTFTLKFKR AEDYPIDLYY LMDLSYSMKD DLENVKSLGT DLMNKMKRIT
SDFRIGFGSF VEKTVMPYIS TTPAKLRNPC TSEQNCTSPF SYKNVLSLTD KGEVFNELVG
KQRISGNLDS PEGGFDAIMQ VAVCGSLIGW RNVTRLLVFS TDAGFHFAGD GKLGGIVLPN
DGQCHLENDV YTMSHYYELK NLIPKSAVGT LSANSSNVIQ LIIDAYNSLS SEVILENSKL
PEGVTINYKS YCKNGVNGTG ENGRKCSNIS IGDEVQFEIS ITSNKCPNKD SETIKIKPLG
FTEEVEIILE FICECECQSE GIPSSPRCHD GNGTFECGAC RCNEGRVGRQ CECSTDEVNS
EDMDAHCRKE NSSEICSNNG ECVCGQCVCR KRDNTNEVYS GKFCECDNFN CDRSNGLICG
GNGVCKCRVC ECNPNYTGSA CDCSLDTSSC LAVNGQICNG RGVCECGACR CTDPKFQGPT
CEMCQTCLGV CAEHKECVQC RAFDKGEKKD TCAQECSHFN VTKVESRDRL PQPGQVDPLS
HCKEKDVDDC WFYFTYSVNG NNEATVHVVE TPECPTGPDI IPIVAGVVAG IVLIGLALLL
IWKLLMIIHD RREFAKFEKE KMNAKWDTGE NPIYKSAVTT VVNPKYEGK
//
