ID S9WUI9_CAMFR Unreviewed; 1370 AA.
AC S9WUI9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Transmembrane channel-like protein {ECO:0000256|RuleBase:RU310713};
GN ORFNames=CB1_000951073 {ECO:0000313|EMBL:EPY79204.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY79204.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY79204.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU310713}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU310713}.
CC Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the TMC family. {ECO:0000256|ARBA:ARBA00006510,
CC ECO:0000256|RuleBase:RU310713}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB017191; EPY79204.1; -; Genomic_DNA.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.4070; -; 1.
DR Gene3D; 1.10.246.90; Nop domain; 1.
DR InterPro; IPR012974; NOP58/56_N.
DR InterPro; IPR042239; Nop_C.
DR InterPro; IPR002687; Nop_dom.
DR InterPro; IPR036070; Nop_dom_sf.
DR InterPro; IPR012976; NOSIC.
DR InterPro; IPR038900; TMC.
DR InterPro; IPR012496; TMC_dom.
DR PANTHER; PTHR23302:SF17; TRANSMEMBRANE CHANNEL-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR23302; TRANSMEMBRANE CHANNEL-RELATED; 1.
DR Pfam; PF01798; Nop; 1.
DR Pfam; PF08156; NOP5NT; 1.
DR Pfam; PF07810; TMC; 1.
DR SMART; SM00931; NOSIC; 1.
DR SUPFAM; SSF89124; Nop domain; 1.
DR PROSITE; PS51358; NOP; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU310713};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU310713};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU310713}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 247..270
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU310713"
FT TRANSMEM 291..313
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU310713"
FT TRANSMEM 387..408
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU310713"
FT TRANSMEM 461..480
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU310713"
FT TRANSMEM 557..579
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU310713"
FT TRANSMEM 600..621
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU310713"
FT TRANSMEM 657..681
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU310713"
FT TRANSMEM 765..785
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU310713"
FT DOMAIN 1067..1185
FT /note="Nop"
FT /evidence="ECO:0000259|PROSITE:PS51358"
FT REGION 1..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1221..1370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1245..1265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1276..1295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1302..1342
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1356..1370
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1370 AA; 155513 MW; 6223EB4770FD20D1 CRC64;
MLKSQWKSQV EEKTLRCLQE GDRSRKRPSR KQTYKAEDAP GRCGAQPGQK ERAGGSPRPG
SPRRKQAERR GRQEQLGERE RRSAAERTSE GRRKWDRTAS LREQRAPPKK ENEAMWKQLK
KHRSSSSASS ASCGESLSEE ELARILEQVE DKKKLIATMR SKPWPMARKL MELREAQEFV
EKYEGALGKG KGKRLYACRM LMAKKWAKFK RDFDNFKTQC IPWEMKIKDI ESHFGSSVAS
YFIFLRWMYG VNLVLFGLIF GLVIIPEGYI KYSALFYGYY NNQRTIGWLR YRLPMAYFMV
GVSVFGYSLM IVIRSMASNT QGSTSEGEND NFTFSFKMFT SWDYLIGNSE TADSKYASIT
TSFKESIVDE QESNKEENVH LTRFLRVLAN FLIICCLCGS GYLIYFVVKR SQEFSKMQNI
SWYERNEVEI VMSLLGMFCP PLFETIAALE NYHPRIGLKW QLGRIFALFL GNLYTFLLAL
MDDVHLKEFM RLTVSDMLVT YITILLGDFL RACFVRFMNY CWCWDLEAGF PSYAEFDISG
NVLGLIFNQG MIWMGSFYAP GLVGINVLRL LTSMYFQCWA VMSSNVPHER VFKASRSNNF
YMGLLLLVLF LSLLPVAYTI MSLPPSFDCG PFSGKNRMYD VIQETIENDF PTFLGKIFAF
LANPGLIIPA ILLMFLAIYY LNSVSKSLSR SNAQLRKKIQ ALREIEKSHK SVKGRATARD
SEETANGNSK NSTQLQLPKD RTEIYLQYRA APERSKSIPG SCSEALHILI LVLFIFQGPC
VTLPAKARPS TRRHRALRPP VLRARLCRPP LSTFLYLGPL APDQALAKPG LRLILGGQPL
ERVLRDLTTD HGDWRKPRPG VEECVLNLGK FHNIVRLVAF CPFSSSQVAL ENANAVSEGV
RLHFHNLVKG LTDLSACKAQ LGLGHSYSRA KVKFNVNRVD NMIIQSISLL DQLDKDINTF
SMRVREWYGY HFPELVKIIN DNATYCRLAQ FIGNRRELNE EKLEKLEELT MDGAKAKAIL
DASRSSMGMD ISAIDLINIE SFSSRVVSLS EYRQSLHTYL RSKMSQVAPS LSALIGEAVG
ARLIAHAGSL TNLAKYPAST VQILGAEKAL FRALKTRGNT PKYGLIFHST FIGRAAAKNK
GRISRYLANK CSIASRIDCF SEVPTSVFGE KLREQVEERL SFYETGEIPR KNLDVMKEAM
VQAEEAAAEI TRKLEKQEKK RLKKEKKRLA AMALASSENS STPEECEATS EKPKKKKKQK
PQEVPQENGM EDPSVSFSKP KKKKSFSKEE LVSSDLEETA GNVSLPKRKK SFPKEEPVSD
LEESGNKSVP KKKRKFSKEE TLSSGPEEPA VAKNSGSKKK KKLRKLSQQD
//
