ID S9X2H5_SCHCR Unreviewed; 4726 AA.
AC S9X2H5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=SPOG_02466 {ECO:0000313|EMBL:EPY51292.1};
OS Schizosaccharomyces cryophilus (strain OY26 / ATCC MYA-4695 / CBS 11777 /
OS NBRC 106824 / NRRL Y48691) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=653667 {ECO:0000313|EMBL:EPY51292.1, ECO:0000313|Proteomes:UP000015464};
RN [1] {ECO:0000313|EMBL:EPY51292.1, ECO:0000313|Proteomes:UP000015464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OY26 / ATCC MYA-4695 / CBS 11777 / NBRC 106824 / NRRL Y48691
RC {ECO:0000313|Proteomes:UP000015464};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR EMBL; KE546991; EPY51292.1; -; Genomic_DNA.
DR RefSeq; XP_013023861.1; XM_013168407.1.
DR STRING; 653667.S9X2H5; -.
DR EnsemblFungi; EPY51292; EPY51292; SPOG_02466.
DR GeneID; 25036789; -.
DR eggNOG; KOG1808; Eukaryota.
DR HOGENOM; CLU_000050_0_2_1; -.
DR OMA; ILEQWHR; -.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000015464; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:EnsemblFungi.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR CDD; cd01460; vWA_midasin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 8.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000015464}.
FT DOMAIN 4514..4716
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 3885..3912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3924..4359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4370..4389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3891..3911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3924..3942
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3962..3980
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3981..4005
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4006..4020
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4029..4059
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4083..4141
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4170..4185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4271..4285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4286..4316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4333..4349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4726 AA; 537048 MW; 6F8867AF8809DFB8 CRC64;
MDELIEWVAI YPQIYDILEH IQYVPTTLLQ RIRLHRSWSE VDYDLWFLYA SDEKRKSCKI
DYNGQLCSYD EFLVLEDQRI ARLNELAEAR SSNENADFLR QLLSNANINS VPLIELGGNL
FFQFHEPLPT TLVQTESAKE NLNRVSPFLV RKQPLLLAGP EGMGKTYFIT QIAALLGQRI
VRIHLTDSTD PKMLIGTYTC PRPGEFEWQP GVLTQAVRHG KWLLLSNIEK APAEVLSILL
PLLERRQLVV PSRGETIYAS NSFQMFATTS TKSTILGQRL WKTVEMVSAP HECIEIVSTI
YPELSSIARI LFSVYNDIYE LFLNRTFLAV SRVYRRLCLR DFYKFTKRVA FLYRHFNVSV
DHATIPQELQ DAIFKEAIDV FSAFIPNKQG VDHVVRNIAI ELNVSPEKAE HFFETIPSFH
DSETTVKIGR SKLPKISSNV FSTSNSYAFT SSSLSLLEKV SVSVQANEPL LLVGETGTGK
TTTVQLLANL LGQRVTVINM SQQTESSDML GGYKPINVTT LGLPLHEEFI SLFEATFSVK
KNMKFLAAAS TAARRFKWKT CLKIWNEALS LSKSLFFKTR SQENPMKRQK RLANQPALEA
RWKNFREEVE QFGKMLEGGS KSFMFSFVEG ALVKAIRSGH WVLLDEINLA CMETLEPIGQ
LLNSYEPGIL LSDRGDVNPV APHPNFRLFG CMNPSTDVGK RELETSLRSR FTEIYVESPD
KNLSDLLSII SKYIGTLCIG DDLVIRDIAE LYQTAKRLSI DGSLVDGAGQ KPHYTIRTLS
RTLCYVAEIV PIYGLRRSLY EGFCMSFLTL LDQNSENLLY KYIERYTLGE LTVQQKNAVL
KQIPKRPEVG DYIAFCHYWL SKGSFPVRDQ EHYIVTPFVQ KNLLNITRAC STRMFPILIQ
GPTSSGKTSM IEYIAGKTGH RFVRINNHEH TDLQEYLGSY VTDDKGSLVF REGILVEALR
NGYWIVLDEL NLAPTDVLEA LNRLLDDNRE LFIPETEALV KPHPDFMLFA TQNPPGVYAG
RKHLSRAFRN RFLEIHFDDI PENELETILH MRCKIAPSYA AKIVQVFREL SLRRQSTRIF
EQKNSFATLR DLFRWAFREA VGYQQLAENG YMLLAERARD PKDKFAVQEV IEKVMKTKIN
TEHLYNLDFI DSIRSDATVG PLKNVVWTAP MIRLFSLVWH CLQAREPVLL VGDTGCGKTT
VCQVLAECFS KQLHIVNAHQ DTENGDIIGA QRPLRNRSLI SNTLHIQLSE KFNVAQEQYS
VEELISKFES LSPLEKNDDL SVVIEKHIKK SNSLFEWHDG ALVSAMKGGD FFLLDEISLA
DDSVLERLNS VLEISRTLTL VEHSDAATVL TAKDGFAFFA TMNPGGDYGK KELSPALRNR
FTEIWVPPMT SVDDIFQIVQ GKLIPAKKHL SEPLVQYAHW HSKVYQNGTN ISIRDVLSAV
DFINLSELSD DKLTLFHAVS MVFVDALGAV STFAFGNNRN MLSDERKKCA SKLGELCDCD
FSSSVTEDLM IRFTESSFYI GDFGIELGPS VNPDSTYNLK THTTKINAAK VVRAMQVRKP
ILLEGSPGVG KTSLISALAR ECGYPLVRIN LSDQTDLMDL FGSDAPVNGG EGGQFTWRDA
PFLSAMRLGH WVLLDELNLA SQTVLEGLNA CLDHRSEAYI PELDRVFKAH PNFRVFAAQN
PQNQGGGRKG LPKSFVNRFT VVYVEPLLQS DMLEIAGQNY RQVDENLRLH IIQFMFKLQE
YVENDASFGI SGRPWEFNLR DAMRWLQLLS EAEKYTCVSP AEYLEVVVLH RMRTDNDRQR
VIELFEQVFG VKYEPRTISS EIDVNILKVG HSFFTRNSVT QRTALDNTKL LQCQYDVLES
MITCINKNWP CILVGPSASG KTCTIRLLAA ACGAELKEMA INSEIDTMDL LGEYEQVDIS
RKISAFLLDL SHEVLNLLIQ YRDFEEILKR TALLRVLQSN FLTLDEGLHI LEWVVAEIRS
IRHHTALFKH LRPYFTLAGK LIKEAFVPAT GKFEWIDGYL LRAVENGHWL VLDNANLCSP
AVLDRLNSLL EYGGTLTVNE RPTESGMPKV IKPHLNFRLF LTVNPYYGEL SRAMRNRGVE
IYMLNNGLTS FDHRQLSKLL PSPICSAVDA RSSSLSFVID VHKRLRDLPA GLVSPYVVAA
VVFSYFSSDQ LDCLRNLCDD QKMLAIDRTP YVNALDRANF SSGQIPNEVL TYIKTYGYPL
LPASMSLVSL MNDFSFITSS NRESEVFWKA YLLNILYAAQ FDLQQINQDV YSSVQSGSID
TYVLKSAYAF LHGISYYRGA LSSVWKLLND LSVYIFNSID KLRKDSSLAS SADLQNLISL
IALWKSMYEW TGTAEFDFSR FHCYSLMLKE WSSKFIADHN SGYLDAPLNL INKFSEALQL
STGEYMQNIW SECHPLVPKT MDHWSLWLRI DTLLKEYLRA NTPSLGMEAT ASHVVSTTLS
LLMNVTNQHE SQDLQSYMQI LEEGVLALKK SKQDQLPEAF YSAFNCLAAL DLLTIYTADY
NNFNVSSEAF TNYIRAALYT RGSTSPLSII TSLNFNASQI PFVVLFDYDF FSLVNGTTFD
LVTRAFASID ENLNIASVKR FEDVRQTLMR HIAERSEQLS ENPLERASIL LLQRIPMFMI
SGIKSGKPSA DEDTILRPLA LPYGELKEQS LSIIDNILSY AERTTDINAS YKKHFLNALE
YLQLSLTAAN HETACKNQAA AYIHFAYGLL LAYVPDKPYD PALLPLLSST NCKDVLKALS
GELKVVEMME DNKSGKKENL LTKSISSCME EINESTPTTT SVFRSLESNS TSLFDELQFL
MDNVVNNSYA LELSLKLMQN PDDSSLEEAK IFKYKWTAFV ERLREAYPYY TDIFEIVISL
ISYMVYGIDI LVAAAKRFLD NRVNASSSLM SHLVSPQKLS KLLMYEDVQD IIQLTSDLQL
NAALKFEVLL FATAKLCKEK KDLPQSSAAN SFTILANEFF TYHAKLVQKE QEEEEEKNRL
FRQRGLNLDN NEYMQIFIDY DEEVEPQPEE KLERTRFSQL QYAFWSLYKS FFIGTEEACS
TDQLLDIGSY LVRKLGLSDF EKSVPADFDI VAAILCLGVK SSKDVDNYWS PPVYNFYSDP
LPYKLIEVRE ILVGLHLHTN SLLKLWPDNF VLRSLKEATD LTLGMSVFIP VAQMLAKFER
LYHLLSEWEK LASRQFSLES DMDLVKSKII EWRQFELSNW KNLLQWEEYK LVEKTYPRLY
TILDYVVLQP LFQKYSLDRS SLNEIASVIL QFFNGLSVGE YRPCLSNLLT FAKHVEALNE
SGGLCATLQQ IYSYLKLFEN NVTHFITVQR RDLENSIKER ILLMSWKDTN VYALKENARK
SHMELYKTLH KYREVLRQPV TPHLSQKLNW EMLLKPTSLS IHNFKDEVKV DYSGLTLDNA
VYANLPARFY NTESTVRVMK SLLKFSHPAN TLFTQAIDEI VSSAHELFKL TPSSANDENI
SEIKHLKTRK HLLMVNAYKT LHAFGFQYRV KAGVEETMKS LQNLFSNIPS FPISFDLIDD
SNTSLSTVLD LIPKVHRLPG NQHDDLTTPE VTRAIGLFDS ALSWLLEERL TLVKFAESLN
RIKLAYQGVG VDGSLKLNFT ASLFKHSESF NYKDFKDYLK ELSSLCSIYS VVLSKHHQIM
SKDTYASVSS CLSEYSTQFT EDTIGSPNPL FISSEQYDCL ESMKMAVNGL VCYCKNHASS
MPEALYWSKS MLSSVKPESA FLGKKVTDLD IRYSTFEKLT ALFDQLLSSA EEVSKCVDSL
GNENTDSTLF DESALVSKLL ASFKLDLFAS KLSDLKKHFE DKYLDEDSTR LFVHFLPVCE
QYIFSAEKAL THFLVKHVKE SQSLHKIASL FLMVATNGYC TPDIPQDDNV QEGGSLESGT
GLGSGSGAKD ISETLNEDDD LEELANEEDT NEQDELEENS EARELDTEMS GATKDAPASD
AEESNSEEDE ELDEEINKDN EGLSEDLNEK MWDEPNEEEL GANEEKSNEQ SVQNNTGELV
SKEEENGDSN ELETSENENK EEESDNEAPG VEDEVQQEAP EDNQNQPENN EVLELPEDLK
LDEGNEGNEE ESDGDEDMPE NVEDTKESEE AEKEDTGEQV DQFEEYDAQD NIEEDIKEED
GFTSQDDAVN GEEQQESQES QEVEEAEDKE SLENDKGHQE SEPDEEVPEE SHNEDVADDF
KDSTTGQDDQ SKSASAQMDT DETVEGADED VTEGAAENGE QGAGATAGEM QADVQETNDQ
ENKLSDEADS ADRQYQSLGD QLREWQQTRQ IHERQPENAE KEAADQQKNI DESTEFAHIA
EEEEEDTQAL GNADKDQVKS LNVNENQEDI SPPEPMEIDS QLDLNDTQLK EEQEAGVESK
QVSESTDKSK FDELNTRNVI HQPNFDQGLE EYDDTEDALV NEGIITTTKL PPSMSIDEAR
VLWQQHEEST RQLSIELCEQ LRLILEPTLA TKMQGDFRTG KRLNMKRIIP YIASQFKKDK
IWMRRVKPSK RTYQVMIAID DSKSMSESKS TKLALETLAL VTKSLSLLEV GQIAVMKFGD
QPELLHPFDK PFSSEVGAEM FSHFSFEQSG TNVLSLTDAS MRLFNYASTN LQVRNKTDQR
QLEIIISDGI CEDHETIRRI LRRAEEEKVM IVFVILDNVN DMKKSSVLDI NKVHYITKDD
GTMELNIQPY IDEFAFEYYL VVRNIEELPQ LLSSALRQWF QQMSNT
//
