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Database: UniProt
Entry: S9XAJ1_CAMFR
LinkDB: S9XAJ1_CAMFR
Original site: S9XAJ1_CAMFR 
ID   S9XAJ1_CAMFR            Unreviewed;      1371 AA.
AC   S9XAJ1;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   11-DEC-2019, entry version 35.
DE   SubName: Full=Toll-like receptor 9 {ECO:0000313|EMBL:EPY84634.1};
GN   ORFNames=CB1_000460012 {ECO:0000313|EMBL:EPY84634.1};
OS   Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX   NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY84634.1, ECO:0000313|Proteomes:UP000030684};
RN   [1] {ECO:0000313|EMBL:EPY84634.1, ECO:0000313|Proteomes:UP000030684}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX   PubMed=23149746;
RG   Bactrian Camels Genome Sequencing and Analysis Consortium;
RA   Jirimutu null, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H.,
RA   Wang L., Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S.,
RA   Zhang W., Batmunkh M., Ts B., Narenbatu null, Unierhu null, Bat-Ireedui S.,
RA   Gao H., Baysgalan B., Li Q., Jia Z., Turigenbayila null,
RA   Subudenggerile null, Narenmanduhu null, Wang Z., Wang J., Pan L., Chen Y.,
RA   Ganerdene Y., Dabxilt null, Erdemt null, Altansha null, Altansukh null,
RA   Liu T., Cao M., Aruuntsever null, Bayart null, Hosblig null, He F.,
RA   Zha-ti A., Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C.,
RA   Chen Y., Tang X., Guo C., Liu W., Ming L., Temuulen null, Cui A., Li Y.,
RA   Gao J., Li J., Wurentaodi null, Niu S., Sun T., Zhai Z., Zhang M., Chen C.,
RA   Baldan T., Bayaer T., Li Y., Meng H.;
RT   "Genome sequences of wild and domestic bactrian camels.";
RL   Nat. Commun. 3:1202-1202(2012).
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DR   EMBL; KB016744; EPY84634.1; -; Genomic_DNA.
DR   Proteomes; UP000030684; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro.
DR   GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro.
DR   GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro.
DR   GO; GO:0034162; P:toll-like receptor 9 signaling pathway; IEA:InterPro.
DR   Gene3D; 3.40.20.10; -; 2.
DR   Gene3D; 3.40.50.10140; -; 1.
DR   InterPro; IPR002108; ADF-H.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR041283; LRR_12.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR027181; TLR9.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR47410:SF3; PTHR47410:SF3; 1.
DR   Pfam; PF00241; Cofilin_ADF; 2.
DR   Pfam; PF18837; LRR_12; 1.
DR   Pfam; PF13516; LRR_6; 1.
DR   Pfam; PF13855; LRR_8; 3.
DR   Pfam; PF01582; TIR; 1.
DR   SMART; SM00102; ADF; 2.
DR   SMART; SM00369; LRR_TYP; 16.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52200; SSF52200; 1.
DR   PROSITE; PS51263; ADF_H; 2.
DR   PROSITE; PS51450; LRR; 16.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Receptor {ECO:0000313|EMBL:EPY84634.1};
KW   Repeat {ECO:0000256|SAAS:SAAS00938886}.
FT   DOMAIN          3..137
FT                   /note="ADF-H"
FT                   /evidence="ECO:0000259|PROSITE:PS51263"
FT   DOMAIN          175..311
FT                   /note="ADF-H"
FT                   /evidence="ECO:0000259|PROSITE:PS51263"
FT   DOMAIN          1206..1347
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   COILED          184..211
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1371 AA;  153613 MW;  2AB1ACDEE02A037F CRC64;
     MFLVLLATEE LKEFFAKARA GSVRLIKVII EDEQLVLGAS RELVGCWDQD YDRAVLPLLD
     AQQPCYLLYR LDTQNAQGFE WLFLAWSPDN SPVRLKMLYA ATRATVKKEF GGGHIKDELF
     GTVKDDLSFA GYQKHLSSCA APAPLTSAER ELQQIRINEV KTEISVESKH QTLQGLAFPL
     QPQAQRALQQ LRQKEINYIQ LKLDLERETI ELVHTEPTDV AQLPSRVPRD AARYHFFLYK
     HTHEGDPLES VVFVYSMPGY KCSIKERMLY SSCKSRLLDS VEQDFQLEIA KKIEIGDGAE
     LTAEFLYDEV HPKQHAFKQA FAKPKGPGGK RGHKRLIRGP GAQGIGRSCP AGSRNWTAAL
     AAALAQGTLP AFLPCELQPH GLVNCNWLFL KSVPHFSAAA PRANITSLSL LSNRIHHLHN
     SDFAHLSSLR SLNLKWNCPP AGLSPMHFPC HMTIEPNTFL AVPTLEELNL SYNSITTVPA
     LPSSLVSLSL SRTSILVLDP THLAGLHALR FLYMDGNCYY KNPCPRALEV APGALLGLGN
     LTHLSLKYNN LTEVPRRLPP SLESLLLSYN HIVTLAPEDL ANLTALRVLD VGGNCRRCDH
     ARNPCIECPK GFPKLHPDTF SHLSRLEGLV LKDSSLYRLD TRWFRGLGSL RVLDLSENFL
     YTCITKTTAF QGLARLTKLN LSFNYHKKVS FAHLHLASSF RGLLSLKELD MHGIFFRSLS
     ETTLQPLAHL PKLQTLHLQM NFINQAQLSI FEAFPGLLYV DLSDNRISGA MRPAATTGKA
     DGRGKLRLPT RNLAQGPLNT LGSEDFMPNC KPFSFTLDLS RNNLVTVQPE MFAHLSRLQC
     LRLSHNSISQ AVNGSQFVPL TSLRVLDLSH NKLDLYHGRS FTELPRLEAL DLSYNSQPFS
     MQGVGHNLSF VAQLPALRYL SLAHNGIHSR VSQQLCSASV RALDFSGNAL SQMWAEGDLY
     LHFFQGLRSL VLLDLSQNHL HTLLPRNLDN LPKSLRLLRL RDNKLAFFNW SSLALLPELE
     ALDLAGNQLK ALSNGSLPSS TQLRRLDLSG NSITFVAPGF FALAKVLQEL NLSANALRTV
     EPSWFGSLVG TLKILDVSAN PLHCACGAVF VDFLLEVQAA VPGLPSRVKC GSPGQLRGRS
     IFAQDLRLCL DEALSWGCFG LSLLTVALGL AVPMLYHLCG WDLWYCFHLC LAWLPRRGQR
     RGADTLLYDA FVVFDKAQSA VADWVYNELR VQLEERRGRR ALRLCLEERD WLPGKTLFEN
     LWASIYSSRK TLFVLAHTDR VSGLLRASFL LAQQRLLEDR KDVVVLVILR PDAYRSRYVR
     LRQHLCRQSV LLWPQQPSGQ GSFWAQLGMT LTRDNRHFYN QNFCRGPTTA G
//
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