ID S9XBN1_CAMFR Unreviewed; 426 AA.
AC S9XBN1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 22-FEB-2023, entry version 22.
DE RecName: Full=4a-hydroxytetrahydrobiopterin dehydratase {ECO:0000256|ARBA:ARBA00013252};
DE EC=4.2.1.96 {ECO:0000256|ARBA:ARBA00013252};
GN ORFNames=CB1_000434030 {ECO:0000313|EMBL:EPY84924.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY84924.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY84924.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin =
CC (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96;
CC Evidence={ECO:0000256|ARBA:ARBA00001554};
CC -!- SIMILARITY: Belongs to the pterin-4-alpha-carbinolamine dehydratase
CC family. {ECO:0000256|ARBA:ARBA00006472}.
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DR EMBL; KB016720; EPY84924.1; -; Genomic_DNA.
DR AlphaFoldDB; S9XBN1; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00914; PCD_DCoH_subfamily_b; 1.
DR CDD; cd02999; PDI_a_ERp44_like; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 3.30.1360.20; Transcriptional coactivator/pterin dehydratase; 1.
DR InterPro; IPR036428; PCD_sf.
DR InterPro; IPR001533; Pterin_deHydtase.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR InterPro; IPR042418; TXNDC15.
DR PANTHER; PTHR14684:SF2; THIOREDOXIN DOMAIN-CONTAINING PROTEIN 15; 1.
DR PANTHER; PTHR14684; UNCHARACTERIZED; 1.
DR Pfam; PF01329; Pterin_4a; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF55248; PCD-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Tetrahydrobiopterin biosynthesis {ECO:0000256|ARBA:ARBA00023007}.
FT DOMAIN 119..236
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 426 AA; 47065 MW; 4A1CF67AE243EE8F CRC64;
MSEEEPPVGQ DTPREEANAV LGLDADGDHM VMLSVIPGEA EDRLSSEPSG AGTCGAGGEE
DSRCNLRESL FSLDSAGASF PDREEEYYTE PEAVESDPTP AEDSNSTESL KSPKVNCEER
NVTGLENFTL KILNMSQDLM DFLNPNGSDC TLVLFYTPWC RFSASLAPHF NSLPRAFPAL
HFLALDASQH SSLSTRFGTV AVPNILLFQG AKPMARFNHT DRTLETLKIF IFNQTGTALV
SLLSKQRSFD CIIEISPIRT ADTVNESVCF CALSQQGRLV AFYHIIQHTG FKRPVLTIVS
LVVDVHQVPG ADPAQHIFCF IITLDSQLVI ILQVSMKNRS QNTRKTLGHH FGLHLMQAFG
FNVPHLMQAF GFMSRVALQA EKMNHHPEWF NVYNKVQITL TSHDCGGLTK RDVKLAKFIE
KAAASV
//
