ID S9XDW6_CAMFR Unreviewed; 754 AA.
AC S9XDW6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Angiotensin-converting enzyme {ECO:0000256|RuleBase:RU361144};
DE EC=3.4.-.- {ECO:0000256|RuleBase:RU361144};
GN ORFNames=CB1_000313018 {ECO:0000313|EMBL:EPY86413.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY86413.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY86413.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361144};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361144};
CC -!- COFACTOR:
CC Name=chloride; Xref=ChEBI:CHEBI:17996;
CC Evidence={ECO:0000256|ARBA:ARBA00001923};
CC -!- SIMILARITY: Belongs to the peptidase M2 family.
CC {ECO:0000256|ARBA:ARBA00008139, ECO:0000256|RuleBase:RU361144}.
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DR EMBL; KB016605; EPY86413.1; -; Genomic_DNA.
DR AlphaFoldDB; S9XDW6; -.
DR MEROPS; M02.004; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008241; F:peptidyl-dipeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd06461; M2_ACE; 1.
DR Gene3D; 1.10.1370.30; -; 1.
DR InterPro; IPR001548; Peptidase_M2.
DR PANTHER; PTHR10514; ANGIOTENSIN-CONVERTING ENZYME; 1.
DR PANTHER; PTHR10514:SF41; ANGIOTENSIN-CONVERTING ENZYME-LIKE PROTEIN ACE3; 1.
DR Pfam; PF01401; Peptidase_M2; 1.
DR PRINTS; PR00791; PEPDIPTASEA.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|RuleBase:RU361144};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180,
KW ECO:0000256|RuleBase:RU361144}; Hydrolase {ECO:0000256|RuleBase:RU361144};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|RuleBase:RU361144};
KW Metalloprotease {ECO:0000256|RuleBase:RU361144};
KW Protease {ECO:0000256|RuleBase:RU361144};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|RuleBase:RU361144}.
FT TRANSMEM 637..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 715..736
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 671..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 754 AA; 87562 MW; 76902B4C89B151C6 CRC64;
MPICFSADKL YNETVAKTFL QFYEHTAQVV WNQFMEATWN YVTNITKKNR EEMLHKDMER
SQHTLYFGTR ARLFNIANFQ DPDVKRMLSN LQNIGKAALP KDKLQEYNQI LAYMETTYSM
GQVCLNEGPC LSLEPDLEEV MATSRDQKEL LWAWQGWRDA VGRQLRTTFE RYVQLSNKAA
KLNGYKDMGA LWRSTYESNM LEEDLEKLYQ ELQPLYLNLH SYVRRALHRF YGPELIDLRG
PIPAHVLGNM WAQSWVSILD LVLPFPEKPP EDITKIMKGQ HWKPEKMFQE AEKFFTSLGL
LSTPPEFWKN SMMERPTDGR EVECHASSWD FYNGKDFRAG VSRQHGIKKC TEVTIEDLLS
IFHQMGHIQY FLQYKNLSVI FRKGANPAFE EAVGSVVTLS ASSHKYLLNR GLLSHQHQDS
EEEVNFLMGI ALQKIAFIPF AYLVDLYRWK IFDGTIQKAV YNQEWWSLRL KYQGLCPPVA
RSEEDFDPGA KFHISASLPY IRYFISLVLQ FQFHEALCKA SGHMGPLHRC DIYNSKEAGK
LLEDVLKLGW SKPWPEVLEK ITGETKVSAK ALMTYFKPLL DWLVTENVRH GDILGWPDFS
CSFEGQDLTF GLEKKETDRV AFLDLELDPD QAKFGQWMLL ALSFVMFLVV LLLAYRLYTL
QKRLLTQDTS AQDTSAQDTS AQDTSAQDTN ALKTPPKAYF LGIAMEPHQV AKRQWMLLGL
CLILILCSIS LIIRISTQHN RMPPWMRSDW WSWD
//
