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Database: UniProt
Entry: S9XFJ9_CAMFR
LinkDB: S9XFJ9_CAMFR
Original site: S9XFJ9_CAMFR 
ID   S9XFJ9_CAMFR            Unreviewed;      1375 AA.
AC   S9XFJ9;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   05-JUN-2019, entry version 36.
DE   SubName: Full=Vascular endothelial growth factor receptor 2 {ECO:0000313|EMBL:EPY86474.1};
GN   ORFNames=CB1_000310012 {ECO:0000313|EMBL:EPY86474.1};
OS   Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Tylopoda;
OC   Camelidae; Camelus.
OX   NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY86474.1};
RN   [1] {ECO:0000313|EMBL:EPY86474.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Naran {ECO:0000313|EMBL:EPY86474.1};
RG   The Bactrian Camels Genome Sequencing and Analysis Consortium;
RA   Yao J., Meng H.;
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EPY86474.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Naran {ECO:0000313|EMBL:EPY86474.1};
RX   PubMed=23149746;
RG   Bactrian Camels Genome Sequencing and Analysis Consortium;
RA   Jirimutu null, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H.,
RA   Wang L., Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S.,
RA   Zhang W., Batmunkh M., Ts B., Narenbatu null, Unierhu null,
RA   Bat-Ireedui S., Gao H., Baysgalan B., Li Q., Jia Z.,
RA   Turigenbayila null, Subudenggerile null, Narenmanduhu null, Wang Z.,
RA   Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt null, Erdemt null,
RA   Altansha null, Altansukh null, Liu T., Cao M., Aruuntsever null,
RA   Bayart null, Hosblig null, He F., Zha-ti A., Zheng G., Qiu F., Sun Z.,
RA   Zhao L., Zhao W., Liu B., Li C., Chen Y., Tang X., Guo C., Liu W.,
RA   Ming L., Temuulen null, Cui A., Li Y., Gao J., Li J., Wurentaodi null,
RA   Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T., Bayaer T.,
RA   Li Y., Meng H.;
RT   "Genome sequences of wild and domestic bactrian camels.";
RL   Nat. Commun. 3:1202-1202(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-
CC         tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|RuleBase:RU000311,
CC         ECO:0000256|SAAS:SAAS01176171};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU000311};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU000311}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. CSF-1/PDGF receptor subfamily.
CC       {ECO:0000256|RuleBase:RU000311}.
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DR   EMBL; KB016602; EPY86474.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019838; F:growth factor binding; IEA:InterPro.
DR   GO; GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IEA:InterPro.
DR   GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 7.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR001824; Tyr_kinase_rcpt_3_CS.
DR   InterPro; IPR041348; VEGFR-2_TMD.
DR   InterPro; IPR009136; VEGFR2_rcpt.
DR   PANTHER; PTHR24416:SF45; PTHR24416:SF45; 2.
DR   Pfam; PF07679; I-set; 2.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF17988; VEGFR-2_TMD; 1.
DR   PRINTS; PR01834; VEGFRECEPTR2.
DR   SMART; SM00409; IG; 7.
DR   SMART; SM00408; IGc2; 5.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF48726; SSF48726; 6.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50835; IG_LIKE; 5.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS00240; RECEPTOR_TYR_KIN_III; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00600564};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00916669};
KW   Immunoglobulin domain {ECO:0000256|RuleBase:RU000311,
KW   ECO:0000256|SAAS:SAAS00941986};
KW   Kinase {ECO:0000256|SAAS:SAAS00601152};
KW   Membrane {ECO:0000256|SAAS:SAAS00602125, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00600689};
KW   Receptor {ECO:0000256|RuleBase:RU000311,
KW   ECO:0000256|SAAS:SAAS00600436, ECO:0000313|EMBL:EPY86474.1};
KW   Repeat {ECO:0000256|SAAS:SAAS00295312};
KW   Transferase {ECO:0000256|SAAS:SAAS00601608};
KW   Transmembrane {ECO:0000256|RuleBase:RU000311,
KW   ECO:0000256|SAAS:SAAS00600943, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
KW   ECO:0000256|SAM:Phobius};
KW   Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00582553}.
FT   TRANSMEM    846    867       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      271    370       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      409    495       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      502    625       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      632    741       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      748    820       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      915   1243       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   REGION     1304   1338       Disordered. {ECO:0000256|MobiDB-lite:
FT                                S9XFJ9}.
FT   COMPBIAS   1304   1334       Polar. {ECO:0000256|MobiDB-lite:S9XFJ9}.
SQ   SEQUENCE   1375 AA;  153255 MW;  4AD696F35D9F5E87 CRC64;
     MIVMSTMGYE IQPTSGETPP AAAAGAGAPL PCAPRSPALR RGFHLRAFSA EQDQGERTGA
     RVLGTALGAR GERDLDWLWP NNQSGSEKRV EVTECSEGIF CKMLTIPKVV GNDTGAYKCF
     YRDTDMASVV YVYVQVFAMV AFQVFVIEAS LEPDIYQQTY LWIPFPDYRS PFIASVSDQH
     GVVYITENKN KTVVIPCLGT ISNLNVSLCA RYPEKRFVPD GNRISWDSKK GFTIPSYMIS
     YAGMVFCEAK INDESYQSIM YIVVVVGYRI YDVVLSPPHG VELSVGEKLV LNCTARTELN
     VGIDFNWEYP SLKHQHKKLV NRDLKTQSGS EMKKFLSTLT IDGVTRSDQG WYTCAASSGL
     MTKKNSTFIT VHGDLEKVSQ RSKCLKAIGR PADWTGGEER ANAKTREKPF VAFVSGMESL
     VEATVGDRVR VPVKYLGYPP PEIKWYKNGR PIESNHTIKV GHVLTIMEVS EKDTGNYTVI
     LTNPISKEKQ SHVVSLVVNV PPQIGEKSLI SPVDSYQYGT SQTLTCTVYA VPPPSHIRWY
     WQLETECTYK PTQAALMTNP YSCKEWRNVE DVQSGNKIEV NKNQFALIEG KNKTVSTLVI
     QAANVSALYK CEAVNKAGRG ERVISFHVTR GPEITLQPST QPTEQESVSL QCSADRTMFE
     NLTWYKLGPQ ALPVRTGELP TPICKNLDVL WKMNATMFSN STNDILIVEL QNASLQDQGD
     YVCFAQDRKT KKRHCVARQL TVLERMAPTI TGNLENQTTS IGETIEVSCT AFGNPPPQIT
     WFKDNETLVE DSGIVLKDGN RNLTIRRVRK EDEGLYTCQA CSVLGCAQVE AFFIVEGAQE
     KTNLEVIILV GTAVLAMFFW LLLVIILRTV KRANGGELKT GYLSIVMDPD ELPLDEHCER
     LPYDASKWEF PRDRLKLGKP LGRGAFGQVI EADAFGIDKT ATCKTVAVKM LKEGATHSEH
     RALMSELKIL IHIGHHLNVV NLLGACTKPG GPLMVIVEFC KFGNLSTYLR SKRNEFVPYK
     SKGARFRQGK EYVGEITVDP KRRLDSITSS QSSASSGFVE EKSLSDVEEE EVPEDLYKNF
     LTLEHLICYS FQVAKGMEFL ASRKCIHRDL AARNILLSEK NVVKICDFGL ARDIYKDPDY
     VRKGDARLPL KWMAPETIFD RVYTIQSDVW SFGVLLWEIF SLGASPYPGV KIDEEFCRRL
     KEGTRMRAPD YTTPEMYQTM LDCWHGEPNQ RPTFSELVEH LGNLLQANAQ QDGKDYIVLP
     ISETLSMEED SGLSLPTSPV SCMEEEEVCD PKFHYDNTAG ISGLMPSKSK ESVASEGSNQ
     TSGYQSGYHS DDTDTTVYSS EEAELLKLVE MGPQAGSAAQ ILQPESGTTL SAPPV
//
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