ID S9XFY8_CAMFR Unreviewed; 458 AA.
AC S9XFY8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=Synaptotagmin {ECO:0000256|RuleBase:RU367154};
GN ORFNames=CB1_000111010 {ECO:0000313|EMBL:EPY89407.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY89407.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY89407.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- FUNCTION: May have a regulatory role in the membrane interactions
CC during trafficking of synaptic vesicles at the active zone of the
CC synapse. It binds acidic phospholipids with a specificity that requires
CC the presence of both an acidic head group and a diacyl backbone.
CC {ECO:0000256|RuleBase:RU367154}.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|RuleBase:RU367154};
CC Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2
CC domains. {ECO:0000256|RuleBase:RU367154};
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle membrane {ECO:0000256|RuleBase:RU367154}; Single-pass membrane
CC protein {ECO:0000256|RuleBase:RU367154}.
CC -!- SIMILARITY: Belongs to the synaptotagmin family.
CC {ECO:0000256|ARBA:ARBA00006996, ECO:0000256|RuleBase:RU367154}.
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DR EMBL; KB016410; EPY89407.1; -; Genomic_DNA.
DR AlphaFoldDB; S9XFY8; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR CDD; cd08385; C2A_Synaptotagmin-1-5-6-9-10; 1.
DR CDD; cd08402; C2B_Synaptotagmin-1; 1.
DR CDD; cd21964; Syt2_N; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001565; Synaptotagmin.
DR PANTHER; PTHR10024; SYNAPTOTAGMIN; 1.
DR PANTHER; PTHR10024:SF223; SYNAPTOTAGMIN-2; 1.
DR Pfam; PF00168; C2; 2.
DR PRINTS; PR00360; C2DOMAIN.
DR PRINTS; PR00399; SYNAPTOTAGMN.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR PROSITE; PS50004; C2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU367154};
KW Cytoplasmic vesicle {ECO:0000256|RuleBase:RU367154};
KW Membrane {ECO:0000256|RuleBase:RU367154};
KW Metal-binding {ECO:0000256|RuleBase:RU367154};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|RuleBase:RU367154};
KW Transmembrane {ECO:0000256|RuleBase:RU367154};
KW Transmembrane helix {ECO:0000256|RuleBase:RU367154}.
FT TRANSMEM 102..123
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367154"
FT DOMAIN 178..297
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 309..442
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 52..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..173
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 458 AA; 50721 MW; AE343DB72C09AC8F CRC64;
MPWGAEGPGQ QGCHSKCDEK PLEGGSVEGG RGWGGFRRPS AAMRSIFKRN QEPAVAPATT
ATPVGPADNS TESGGTGKTK DMFAKMGEQF FNDMKLIPLP PWALIAVVVV VGLLLLTCCF
CICKKCCCKK RKNKKEKGKG AKSAMSMRDM RGGQDDDDAE TGLTEGEGEG EEEKEPENLG
KLQFSLDYDF QANQLTVGVL QAAELPALDM GGTSDPYVKV FLLPDKKKKY ETKVHRKTLN
PAFNETFTFK VPYQELGGKT LVMAIYDFDR FSKHDIIGEV KVPMNTVDLG QPIEEWRDLQ
GGEKEEPEKL GDICTSLRYV PTAGKLTVCI LEAKNLKKMD VGGLSDPYVK IHLMQNGKRL
KKKKTTVKKK TLNPYFNESF SFEIPFEQIQ KVQVVVTVLD YDKLGKNEAI GKIFVGSSAT
GTELRHWSDM LANPRRPIAQ WHSLKPEEEV DALLGKNK
//
