ID S9XNT3_CAMFR Unreviewed; 2794 AA.
AC S9XNT3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Fibrillin-3 {ECO:0000313|EMBL:EPY76816.1};
GN ORFNames=CB1_001381005 {ECO:0000313|EMBL:EPY76816.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY76816.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY76816.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KB017569; EPY76816.1; -; Genomic_DNA.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0031012; C:extracellular matrix; IEA:UniProt.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 27.
DR Gene3D; 2.10.25.10; Laminin; 44.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 7.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR049388; FBN_EGF_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF46; LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 3; 1.
DR Pfam; PF12662; cEGF; 5.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 32.
DR Pfam; PF21364; FBN_EGF_st1; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 7.
DR PIRSF; PIRSF036312; Fibrillin; 6.
DR SMART; SM00181; EGF; 45.
DR SMART; SM00179; EGF_CA; 43.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 14.
DR SUPFAM; SSF57581; TB module/8-cys domain; 7.
DR PROSITE; PS00010; ASX_HYDROXYL; 40.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 21.
DR PROSITE; PS50026; EGF_3; 40.
DR PROSITE; PS01187; EGF_CA; 15.
DR PROSITE; PS51364; TB; 7.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 72..104
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 110..153
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 172..213
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 214..255
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 325..363
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 366..405
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 406..447
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 448..488
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 489..529
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 535..587
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 599..640
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 641..682
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 683..722
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 727..766
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 786..827
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 832..870
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 884..925
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 938..980
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 981..1022
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1023..1064
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1179..1216
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1221..1259
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1262..1302
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1328..1369
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1370..1406
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1411..1451
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1456..1512
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1529..1570
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1571..1612
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1617..1669
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1687..1724
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1729..1770
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1814..1849
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1853..1895
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1896..1933
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1950..1991
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2059..2096
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2101..2140
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2141..2181
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2182..2226
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2227..2268
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2273..2326
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2338..2375
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2421..2457
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2460..2498
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2503..2537
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2543..2580
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 2030..2058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 76..86
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 94..103
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 370..380
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 687..697
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1818..1828
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2507..2517
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2794 AA; 297210 MW; 9ED649C152E8530C CRC64;
MIGTVSFGNS IGHACGEGFC SRPNLCACAD GKLAPSCGVN RGSGCSVSCM NGGSCQGESC
LCQRGYTGTV CGQPICDRGC HNGGRCIGPN HCACVYGFMG PQCERDYRTG PCFGQVGPEG
CQHQLTGLAC TKALCCATVG RAWGLPCELC PAQPHPCRRG FIPNIRTGAC QDVDECQAVP
GLCQGGSCVN TVGSFECRCP SGHRLSENSA KCEDVNECLS VPGLCSGGDC TNTVGSYVCT
CPRGFASSLD GTRCLDEFQR LCALGLPLLP PYPARFPSIP GFGSSGGLGP GLGPAWHSPQ
GSNGRGVPSL GFGDTNIGTA TLNQTIDICQ HFTNLCLNGR CLPTASSYRC ECNMGYKQDV
RGECIDVDEC ASSPCRHGDC VNTPGSYHCR CHEGFQAMVT KQVCLDVDEC VVSSGLCHHG
RCVNTEGSFQ CVCNAGFKLS PDGKNCVDHN ECATTTMCAN GVCLNEDGSF TCLCKPGFLL
APSGRHCVDI DECQTPGICM NGHCTNTEGS FRCRCLGGLA VGADGRVCVD THVRSTCYGA
LDKGSCARPF PGAVTKSECC CASPDHGFGE PCQLCPAKDS AEFQALCSSG LGITTDGRDI
NECALDPDVC ANGICENLRG SYRCICNLGY EASAGGKECA DVDECALNSL LCDNGWCRNS
PGSYSCSCPQ GFSFQQDTET CEDVDECLSH PCVNGMCLNL AGSYTCECAP GSRLGPTGTV
CLDSTKGTCW LKVQDGRCEA NLHGATLRSE CCATLGAAWG SPCERCDMDP ACAHGFARTM
GLTCEDVNEC DVFPGVCSNG RCLNTAGSFR CECPQGLTLD TTGRLCVDMR LELCFLRWDE
DECGAALPGK YRMDVCCCSV GAAWGASCEP RLPVFLSGRP FYKDVNECKA FPGLCAHGTC
RNTVGSFRCS CAGGFTLDAQ ERNCTDVEAR PAPTLSTDID ECRISPDLCG HGTCVNTLGS
FECECFHGYE SGFMLMKNCV DVNECARDPR LCRGGTCTNT DGSYECLCPT GHALAAKGTA
CEDIDECSLS DGLCPHGQCI NVIGAFQCSC HAGFQSAPDG RGCVXXXXXX XXXXVDECEE
SPDICDGGQC TNVPGGHRCL CHDGFAATPD TRTCLGEELG LLQAGEMRLC TWWAAPGHQC
PEPVHQGPWH LIHSSRAPPN LILLNMFDDT YRVPSAYRDV DECDLNPHIC LHGDCENTRG
SFVCHCQLGY AVRKGATGCS DVNECELGGH SCDGHASCLN IPGSFSCRCQ PGWVGDGFEC
HDLDECTFQE HQCSPRADCL NTPGSYRCAC LPGFAGDGFS CEGCAFSPGG HRPGLSPLGQ
SSPLDSEYRD ECAENVDLCE NGQCLNAPGG YRCECEMGFN PMEDQRACQD VDECVLGNLC
VSGSCENLPG MFRCICDEGY ELDRGGGNCT DVNECADPVN CINGLCVNTP GSYLCNCPQD
FELNPSGVGC VDTRVGNCFL DTHDRGDGGI SCSAEIGVGV TRASCCCSLG QAWGNPCELC
PMANTTEYRT LCPGGEGFRP NPVTVILEDI DECQELPGLC QGGDCVNTFG SFQCECPPGY
HLNEDTRICE DIDECSVHSG ICGPGTCYNT LGNYTCVCPA EYLQVNGGNN CMDMRKSICF
RHYNGTCRNE LAFNVTRKMC CCSYNIGQAW NRPCEACPTP TSLDYQILCG NQIPGFVIDI
HSGKPVDIDE CGEIPAICAN GVCINQIGSF RCECPTGFRY DRVLLVCKDM DECASGENPC
QQNAECVNIP GSYRCTCAQG YKLSPGGACV GRNECQEIPN ICSHGDCVDT VSSYMCLCHR
GFRASADQTL CMADIDECDR QPCGNGTCKN IVGSYSCLCF PGFMVTHNGD CVDVDECTTM
VGQVCRFGQC LNTAGSFHCL CQDGFELTRD GKNCADTNEC LSLAGTCLPG TCQNLEGSFR
CICPPGFQDH LTLVEDLLTP HISCVPATPD IDECSEEPNL CLFGTCTNSP GSFQCFCPPG
FVLSDNRRRC FAAFQELCPF GHGAVPGPDD SREALPGLYP GFPSLILPPG PTGGPRLRAS
ERGQGVTDTP HLQPVTPSDV NECAENPGVC TNGLCVNTDG SFRCECPFGY SLDSTGVSCV
DTDECSGGRP CGEGTCTNVI GGFECACADG FEPGPTMTCE DIDECSLNPL LCAFRCHNTE
GSYVCTCPAG YTLREDGAMC RDVDECADGH QDCRARGMLC KNLIGTFTCI CPPGLRPQPG
SGEGCTDDDE CRVQPGLCAN GRCVNTAGSF RCDCDEGFQP SPSLTECHDI RQGPCFSEVL
QAVCQVPSSG VEVVSRAECC CGGGRTWGPR CELCPLPGTS AHRKLCPHGS GYTADGRDVD
ECRVLAHLCP YGECINSLGS FRCHCRAGYA PDAAATACLD VDECSLAPTP CPFLCKNTEG
SFLCACPRGY LLAENGRTCR DLDECASGQH NCQFFCVNTI GAFSCRCPPG FTQRRQACFD
NDECSAQPDP CGTRGRCHNT PGSFSCECSQ GFALDSSGRD CKDVDECDGP HRCQHGCQNE
LGGYRCSCPQ GFTPHSQWGQ CVDQNECVLS PAACGSASCH NTLGGFRCVC PSGFNFDQAL
GGCKDVDECV AHSSPCSYSC ANTPGGFLCG CPRGYFRAGQ GHNARYPLPC NARKHCVSGL
GFSPGPQDTP DEEKLLSPEA CYECKINSQP PRDRPRRSTH RDHQVSLASL DSEAPLTLGL
DLSRLGPAGH ILELRPALES LGGRVRYVIA RGNEQGFFRM YHLRGLSSLQ LGRRRPGPGT
YQLEVVSVAE PWGTRPEGQP GDQALRLKVQ VQLL
//
