ID S9XPU7_CAMFR Unreviewed; 417 AA.
AC S9XPU7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Glial fibrillary acidic protein {ECO:0000256|ARBA:ARBA00018571};
GN ORFNames=CB1_000085010 {ECO:0000313|EMBL:EPY89684.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY89684.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY89684.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- FUNCTION: GFAP, a class-III intermediate filament, is a cell-specific
CC marker that, during the development of the central nervous system,
CC distinguishes astrocytes from other glial cells.
CC {ECO:0000256|ARBA:ARBA00002194}.
CC -!- SUBUNIT: Interacts with SYNM. {ECO:0000256|ARBA:ARBA00024375}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; KB016384; EPY89684.1; -; Genomic_DNA.
DR AlphaFoldDB; S9XPU7; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF9; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR Pfam; PF00038; Filament; 2.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684}.
FT DOMAIN 65..362
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 69..103
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 140..206
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 260..333
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 417 AA; 48090 MW; A9D47D3AD9D8C99B CRC64;
MERRRVTSSA RRSYVSSSEM VVGGRRLGPG TRLSLARMPP PLPARVDFSL GGALNAGFKE
TRASERAEMM ELNDRFASYI EKVRFLEQQN KALAAELNQL RAKEPTKLAD VYQAELRELR
LRLDQCGCIN SLPTAPGSRL QDETNLRLEA ENNLAAYRQE ADEATLSRLD LERKTESLEE
EIRFLRKIHE EEVRELQEQL AQQQVHVEMD VAKPDLTAAL REIRTQYEAV ASSNMHEAEE
WYRSKFADLT DAAARNAELL RQAKHEANDY RRQLQALTCD LESLRGTNES LERQMREQEE
RHVREAVNYQ EALARLEEEG QSLKDEMARH LQEYQDLLNV KLALDIEIAT YRKLLEGEEN
RITIPVQTFS NLQIRETSLD TKSVSEGHLK RNIVVKTVEM RDGEVIKESK QEHKDVM
//
