ID S9XQ79_CAMFR Unreviewed; 715 AA.
AC S9XQ79;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Importin subunit alpha-5 {ECO:0000256|ARBA:ARBA00041122};
DE AltName: Full=Karyopherin subunit alpha-1 {ECO:0000256|ARBA:ARBA00041488};
GN ORFNames=CB1_001278024 {ECO:0000313|EMBL:EPY77291.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY77291.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY77291.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394}.
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DR EMBL; KB017483; EPY77291.1; -; Genomic_DNA.
DR AlphaFoldDB; S9XQ79; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF3; IMPORTIN SUBUNIT ALPHA-5; 1.
DR Pfam; PF00514; Arm; 7.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Transport {ECO:0000256|PROSITE-ProRule:PRU00561}.
FT DOMAIN 1..57
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 135..178
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 178..206
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 220..248
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 715 AA; 79019 MW; FE17B4D409AD4320 CRC64;
MTTPGKENFR LKSYKNKSLN PDEMRRRREE EGLQLRKQKR EEQLFKRRNV ATAEEETEEE
VMSDGGFHEA QINNMEMAPI SNMKEMLKWR EGYYEVSLSY KVLALKSKDC FSSFLLFYGE
TEPNPPIDEV ISTPGVVARF VEFLKRKENC TLQFESAWVL TNIASGNSLQ TRIVIQAGAV
PIFIELLSSE FEDVQEQAVW ALGNIAGDST MCRDYVLDCN ILPPLLQLFS KQNRLTMTRN
AVWALSNLCR GKSPPPEFAK VSPCLNVLSW LLFVSDTDVL ADACWALSYL SDGPNDKIQA
VIDAGVCRRL VELLMHNDYK VVSPALRAVG NIVTGDDIQT QTVIDANIFP ALISILQTAE
FRTRKEAAWA ITNATSGGSA EQIKYLVELG CIKPLCDLLT VMDSKIVQVA LNGLENILRL
GEQEAKRNGT GINPYCALIE EAYGLDKIEF LQSHENQEIY QKAFDLIEHY FGTEDEDSSI
APQVDLSQQQ YIFQQSLSYP GSRPQVEGNR TKATCEAGAH KESPADGWTH GPYIPQMRSP
KGLLSNAGLT LRPRTPHNSV LSRHTVSKKK CTFLETFTAS HSSQSGLGET LLTSLAQASS
PGNAQGRSQR TEPADGASGR SQRTEPADGA SGRSQRTEPA DGASGRSQRT EPADGASGRS
QRTEPADGAS GRSQRTEPAD GESLATPRCR RQAPVSSNSA YASFRLASEI FCLKR
//
