ID S9XTE5_CAMFR Unreviewed; 523 AA.
AC S9XTE5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Growth hormone secretagogue receptor type 1 {ECO:0000256|ARBA:ARBA00018726};
DE AltName: Full=GH-releasing peptide receptor {ECO:0000256|ARBA:ARBA00033151};
DE AltName: Full=Ghrelin receptor {ECO:0000256|ARBA:ARBA00032291};
GN ORFNames=CB1_001066023 {ECO:0000313|EMBL:EPY78446.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY78446.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY78446.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- FUNCTION: Receptor for ghrelin, coupled to G-alpha-11 proteins.
CC Stimulates growth hormone secretion. Binds also other growth hormone
CC releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as
CC non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-
CC 0677, adenosine). {ECO:0000256|ARBA:ARBA00024836}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; KB017296; EPY78446.1; -; Genomic_DNA.
DR AlphaFoldDB; S9XTE5; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15131; 7tmA_GHSR; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR003905; GHS-R/MTLR.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24243; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24243:SF7; GROWTH HORMONE SECRETAGOGUE RECEPTOR TYPE 1; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01417; GHSRECEPTOR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 17..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 238..480
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 155..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 523 AA; 59278 MW; 5C52B6E7D473ABD7 CRC64;
MASVQAPGGA SPGQTCVLML IFTVLLQSLC VAITYVYFTN ELKQIQDKYS KSGIGCFLKE
DDSSWDPSDE ESMINPCWQV KWQLRQFIRK VKFHFLIYIV PKNLNDPHLG HGQVSVNRCG
QRNCLVQVCV QEESPGSLLE QDWGAEARIE KEDLLQDQPD PASQRSSIQE PVKQSRRSMW
NATPSEEPGP NLTLQDLSWD APPDNDSLAD ELLPLFPTPL LAGVTATCVV LFLMGIAGNL
LTMLVVSRFR ELRTTTNLYL SSMAFSDLLI FLCMPLDLVR LWQYRPWNFG DLLCKLFQFV
SESCTYATVL TITALSVERY FAICFPLRAK VVITKGRVKL VILVIWAVAF CSAGPIFVLV
GVEHENGTDP RDTNECRATE FAVRSGLLTV MVWVSSVFFF LPVFCLTVLY SLIGRKLWRR
RRAVVVFAFI LCWLPFHVGR YLFSKSFEPG SLEIAQISQY CNLVSFVLFY LSAAINPILY
NIMSKKYRVA VFRLLGFEPF SQRKLSTLKD ESSRAWTESS INT
//
