ID S9XY38_CAMFR Unreviewed; 2253 AA.
AC S9XY38;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=G-protein coupled receptor 115 {ECO:0008006|Google:ProtNLM};
GN ORFNames=CB1_001402123 {ECO:0000313|EMBL:EPY76620.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY76620.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY76620.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR EMBL; KB017589; EPY76620.1; -; Genomic_DNA.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR CDD; cd15074; 7tmA_Opsin5_neuropsin; 1.
DR CDD; cd15994; 7tmB2_GPR111_115; 1.
DR CDD; cd12053; SH3_CD2AP_1; 1.
DR CDD; cd12054; SH3_CD2AP_2; 1.
DR Gene3D; 2.60.220.50; -; 2.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR035775; CD2AP_SH3_1.
DR InterPro; IPR035776; CD2AP_SH_2.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR027430; Retinal_BS.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45813:SF1; ADHESION G PROTEIN-COUPLED RECEPTOR F4; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF00002; 7tm_2; 2.
DR Pfam; PF01825; GPS; 2.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00303; GPS; 2.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 2.
DR PROSITE; PS50221; GPS; 2.
DR PROSITE; PS00238; OPSIN; 1.
DR PROSITE; PS50002; SH3; 2.
PE 3: Inferred from homology;
KW Chromophore {ECO:0000256|ARBA:ARBA00022991};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Photoreceptor protein {ECO:0000256|ARBA:ARBA00022543};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Retinal protein {ECO:0000256|ARBA:ARBA00022925};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 946..971
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 983..1009
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1029..1052
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1059..1083
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1103..1128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1149..1172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1178..1201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1589..1610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1645..1662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1669..1690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1710..1734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1755..1777
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1783..1803
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1872..1890
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1981..2002
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2023..2042
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2071..2093
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2126..2150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..61
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 110..169
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 947..1202
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT DOMAIN 1553..1808
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT DOMAIN 1955..2179
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 174..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..279
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2253 AA; 249491 MW; 16F840EC2A2666D1 CRC64;
MNRVDYIVEY DYDAVHDDEL TIRVGEVIRN VRKLQEEGWL EGELNGRRGM FPDNFAKEVK
RETESKDDSL PIKRERHGNV ASLVQRISTY GLLAGGIQPH PQTKNIKKKT KKRQCRVLFE
YIPQNEDELE LKVGDVVDIS EEVEEGWWSG TLNNKLGLFP SNFVKELEVT YDGETHEAQE
DSETFLTGST SPSPSPGNGN EAAPGSVTQP KKIRGVGFGD IFKEGSVKLR TRTSSSETEE
KKPEKPLITQ SLGPKTQSME TTKIDTEGKF KDEKSVLEQK PKPAAPQVPP KKPTPPTKAN
NLLKSSGTVY PKRPEKPVPP PPPVAKINGE VSSILSKFET EPISKPKLES EQLPLRPKSV
DLDSFTVRSS KETDLINFDD IASSENLLHL TANRPKMPGR RLPGRFNGGH SPTQSPEKIS
KLPKEDDSAN LKPSELKKDP CYSPKPSAYL STPSSASKPN MAAFLTPLEI KAKAETDDGK
KNSLDELRAQ IVELLCIVEA LKKDHGSKKG SCAEDNASGA SAVLLRVSLA HRVLQEVMPG
CQQEQGAGVR QATRQKKWHK ITDTCRTLTA FNIFELIHPN PARHFCFKSV PPSLLGSGRD
ELLRHQELAY PHRASVQCAP TDGVGAAAPK TAVAVLRRGR VGDKLGLRFL LKHLGIRQAG
EYSIQPSGGT KITEYANKKS ETITDVLMRK CPRDLSCVIR NIQRSPRIPG NIAVIVQLLR
NISTVLTTDV DEAKMQSYSI MANHILNSKS ISNWTFIPDR NSSWVLLHSV NSFARKLFIN
KHPIDIADVF IHTMGTTISR DDTGKNFSFS MRVNDTGDEV TGRVSISRDE LQKMPSPSKA
ISIAFPTLGA ILEASVLENV TVNGLVLSVI LPKELQRISL IFEKISKSEE MRTQCVGWHS
LESRWDQQAC QMIQENSQQA VCTCQPSRLF TSFSILMAPH VLESPILVYI TYIGLGISIC
SLVLCLSIEA LVWGEVTKTE ISYLRHVCIA NIAASLLVAD VWFIVAAFLS GPATSHSACV
AATFFVHFFY LSVFFWMLAK ALLILYGILI VFHTLPKSAL VASLFTVGYG CPLVIAAITV
AATEPGKGYL QPETCWLNWD MTKALMAFVV PALAILVVNL VTVTLVIVKT RQAAVGSSMF
QEVRAIVRIS KNIAILTPLL GLTWGFGIAT VLDDRSLAFH IIFSLLNAFQ GFFILVFGTI
LDPKIWRRWG RGPWEAPGRA RDGGHGGGKP APTFPLGRLV SRMDADGDKL QGPEGKPKTG
KMQAPFIPLH ILDFRAPEPI KSVAHGIRKN CPLDFACIVD TVKSSEATSG NIAFIVEILK
NISTDLSDNV TREKMKSYSK VANHILDPAV IPNWAFIPDK NASSDLLQAV NAFARRLRIY
HEPEHIVDEL FIQTKGFPIN HNTQGRSFNF SSNVSNTTEG ILGIVEIPSQ ELWKLPPNAS
LAISIAFPTL GAVLKEAHLQ DEDLPRPVNG LVLSVILPEE LKQILLTFEK INRPRNARAQ
CVGWHSSRRR WDESVCETAL DVANRAKCRC NYTNAVTSFS ILMSPRSIDN KVLDYITCIG
LSSSILSLIL CLIIEATVWS RVVVTEISYM RHVCIVNIAV SLLTANVWFI LGTNFNRKAQ
DYNWCVAVTF FSHFFYLSLF FWMLFKALLI IYGILVVFRR MMKSRMMAIG FAIGYGCPLV
IAVTTVAVTV PGRGYTRHGA CWLNWDDTKA LLAFAIPALV IVAVNLVVVL VVAVNTQRPS
IGSSKSQDLA IIMRISKNVA ILTPLLGLTW GFGIATLLQG TSLIFHIIFA LLNAFQGFFI
LLFGTIMDHK NASLSPTNGS KLMHRKFNEI QEGRDESIDP KIKWTRVSAD SECRMTALTA
DSRMPLKRGY KVGFRILVTC IASAFQARAL QHRMALNHTA PPPDERRPRH LRDGDPFASK
LSWEADLVAG FYLTIIGQVR GYAPISSKEP EWNDILVVGK PFTIISCFCH RWMFGWIGCR
WYGWAGFFFG CGSLITMTAV SLDRYLKICY LSYGVWLKRK HAYICLAVIW AYASFWTTMP
LVGLGDYAPE PFGTSCTLDW WLAQASVGGQ IFILNILFFC LLLPTAVIVF SYVKIIAKVK
SSSKEVAHFD SRIHSSHVLE MKLTKVAMLI CAGFLIAWIP YAVVSVWSAF GRPDSIPIQL
SVVPTLLAKS AAMYNPIIYQ VIDYKFACCQ TGGLKATKKK SLEDFRLHTV TTVRKSSAVL
EIHQEGGVDL KGAFGACAGE EMDSSFSSLS ASP
//
