ID S9Y5D7_CAMFR Unreviewed; 944 AA.
AC S9Y5D7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE Flags: Fragment;
GN ORFNames=CB1_000639022 {ECO:0000313|EMBL:EPY82631.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY82631.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY82631.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005601}.
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DR EMBL; KB016909; EPY82631.1; -; Genomic_DNA.
DR AlphaFoldDB; S9Y5D7; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0032574; F:5'-3' RNA helicase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR CDD; cd18038; DEXXQc_Helz-like; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR049080; MOV-10-like_beta-barrel.
DR InterPro; IPR026122; MOV-10/SDE3_DEXXQ/H-box.
DR InterPro; IPR049079; Mov-10_helical.
DR InterPro; IPR049077; MOV-10_Ig-like.
DR InterPro; IPR049075; MOV-10_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF537; HELICASE MOV-10; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF21634; MOV-10_beta-barrel; 1.
DR Pfam; PF21635; Mov-10_helical; 1.
DR Pfam; PF21633; MOV-10_Ig-like; 1.
DR Pfam; PF21632; MOV-10_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684}.
FT DOMAIN 3..31
FT /note="Helicase MOV-10 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21632"
FT DOMAIN 69..196
FT /note="Helicase MOV-10 Ig-like"
FT /evidence="ECO:0000259|Pfam:PF21633"
FT DOMAIN 246..312
FT /note="Helicase MOV-10 helical"
FT /evidence="ECO:0000259|Pfam:PF21635"
FT DOMAIN 313..402
FT /note="Helicase MOV-10-like beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF21634"
FT DOMAIN 454..524
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 565..642
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 654..876
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 923..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EPY82631.1"
SQ SEQUENCE 944 AA; 106228 MW; 82E274A8B59A977F CRC64;
SFGTPAPGFS SMLYGMKIAS LAYVTKTRVR FFRLDRWADV WFPEKRKVKL GSDISKHHKS
LLAEIFYDRA EYLHGKHGVD VEVQGPHEAR DGQLLIRLDL NRKEVLTLKL RNGGTQPVTL
THLFPLCRTP QFAFYNGDQE LPCPLGPGEC YELHVHCKTS FVGYFPATVL WELLGPGEPG
SEGAGTFYVA RFLAAVAHSP LAAQLKPTTP FKRTQITRNP VVTSRIEEGE RPDRAKSYDL
ELSMALGTYS PPPRLRQLLP ILLRGTSIFT APKEIAEIKA QLETTLKWRN YEVKLRLLLH
LEELQMEHDI RHYDLESVPM TWDPVDQNPG LLTLEVPGVA ESRPSVLRGD HLFALLSSET
HHEDPVTYKG FVHKVELDRV KLSFSTSLLS RFVDGLTFKV NFTFNRQPLR VQHRALELTG
RWLLWPMLFP VAARGVPLLP SDVKLKLYDR SLESNPEQLQ AMKHIVMGTT RPAPYIIFGP
PGTGKTVTLV EAIKQVVKHL PKAHILACAP SNSGADLLCQ RLRVHLPSSI YRLLAPSRDI
RMVPEDIKPC CNWDAKKGDY VFPSKKKLQE YRVLITTLIT ASRLVSAQFP IDHFTHIFID
EAGHSMEPES LVAIAGLMEV KEADNPGGQL VLAGDPRQLG PVLRCPLTQK YGLGYSLLER
LLTYNALYKK GPEGFNPQFI TKLLRNYRSH PTILDIPNRL YYEGELQACA DVVDRERFCR
WEGLPRQGFP IIFHGVMGKD EREGNSPSFF NPEEAATVTS YLKQLLAPSS KKGKARLSPR
SVGVISPYRK QVEKIRYCIT KLDKELRGLD DIKDLKVGSV EEFQGQERSV ILISTVRSSQ
SFVQLDLDFN LGFLKNPKRF NVAVTRAKAL LIVVGNPLLL GHDPDWKAFL EFCKENGGYT
GCPFPAKLDL QQGQNLLQGL SKLSPSTSGE ETQWEVAGKP PTGF
//
