ID S9YHN4_CAMFR Unreviewed; 2053 AA.
AC S9YHN4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN ORFNames=CB1_000295003 {ECO:0000313|EMBL:EPY86846.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY86846.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY86846.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; KB016587; EPY86846.1; -; Genomic_DNA.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 5.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 5.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR008053; Na_channel_a5su.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF206; SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 2.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR PRINTS; PR01666; NACHANNEL5.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132, ECO:0000313|EMBL:EPY86846.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..2053
FT /note="Sodium channel protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004561475"
FT TRANSMEM 92..113
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 254..282
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 701..724
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 744..761
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 781..804
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1184..1205
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1233..1259
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1337..1363
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1449..1467
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1479..1497
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1509..1529
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1566..1594
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1614..1641
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 1..288
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 314..473
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 524..810
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 818..857
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 873..1075
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1079..1371
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1448..1599
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 886..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1826..1855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 279..310
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 903..917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1827..1855
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2053 AA; 229831 MW; 50866117F62A13DC CRC64;
MLIMCTILTN CVFMAQHDPP PWTKYVEYTF TAIYTFESLV KILARGFCLH AFTFLRDPWN
WLDFSVIIMA YTTEFVDLGN VSALRTFRVL RALKTISVIS GLKTIVGALI QSVKKLADVM
VLTVFCLSVF ALIGLQLFMG NLRHKCVRNF TMLNGTNGSV EADGLVWESL DLYLNNPENY
LLKNGTSDVL LCGNSSDAGT CPEGYRCLKA GENPDHGYTS FDSFAWAFLA LFRLMTQDCW
ERLYQQTLRS AGKIYMIFFM LVIFLGSFYL VNLILAVVAM AYEEQNQATI AETEEKEKRF
QEAMEMLKKE HENRLSITHG LSRTSLKPRS SRGSIFTFRR RDLGSETDFA DDENSTAGDS
ESHRTSLLVP WPLRWPSAQG QPSPGTSTLG HVLNGKRNST VDCNGVVSLL GVGDPEATSP
GSRLLRPMML ERPLDTTTPS EEPGRPQMLT PQAPCADGFE EPAERQRALS AVSALTSVLE
ELEESHRKCP PCWTRFAQRY LIWECCPLWM SIKQKVKFMV MDPFADLTIT MCIVLNTLFM
ALEHYNMTTE FEEMLQVGNL VRGRWQLTLK RVSWCEGPAF MDPALSVPAA QVTRKGKQVS
YTVKWSTKDS GVYDSDKVFT GIFTAEMTFK IIALDPYYYF QEGWNIFDSI IVILSLMELG
LSRMGNLSVL RSFRLLRVFK LAKSWPTLNT LIKIIGNSVG ALGNLTLVLA IIVFIFAVVG
MQLFGKNYSE LRHRISDSGL LPRWHMMDFF HAFLIIFRIL CGEWIETMWD CMEVSGQSLC
LLVFLLVMVI GNLVVLNLFL ALLLSSFSAD NLTAPDEDGE LNNLQLALAR IQRALRFIKR
TTWDFCCGLL QRRPQKPAAL ATQGQLPSCG TPEDPEPVCV PIAVAESDTD DQEEDEENSL
STGEESSKQQ ESQPVSCGPE ALPQPRAWSQ VSETTSSRAE ASAAPADLRQ QRRAGARAPG
CSEQIWEKGV TLKAMGTTET PRATLYPGAL YHLPGIQSFL ITNLKMPEDS YSEGSTADMT
NTADLLEQIP DLGEDVKDPE DCFTEGCVRR CPCCTVDTTQ SPGKVWWRLR KTCYRIVEHS
WFETFIIFMI LLSSGALIRP RPLGSSQCQG WGLGRVGLGV VGRHGHLVRI GLQAFEDIYL
EERKTIKVLL EYADKMFTYV FVLEMLLKWV AYGFKKYFTN AWCWLDFLIV DVSLISLVAN
ALGFAEMGPI KSLRTLRALR PLRALSRFEG MRVVVNALVG AIPSIMNVLL VCLIFWLIFS
IMGVNLFAGK FGRCINQTEG DLPLNYTIVN NKSDCESFNM TGELYWTKVK VNFDNVGAGY
LALLQVYEEQ PQWEYNLYMY IYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKIPYLRDEA
LRDAGGRVGT VPLVLDQGQR GGQDIFMTEE QKKYYNAMKK LGSKKPQKPI PRPLNKYQGF
IFDIVTKQAF DVTIMFLICL NMVTMMVETD DQSPEKVNIL AKINLLFVAI FTGECIFKMA
ALRHYYFTNS WNIFDFVVVI LSIVGTVLSD IIQKYFFSPT LFRVIRLARI GRILRLIRGA
KGIRTLLFAL MMSLPALFNI GLLLFLVMFI YSIFGMANFA YITTNGSRGN CGSPAVGILF
FTTYIIISFL IVVNMYIAII LENFSVATEE STEPLSEDDF DMFYEIWEKF DPEATQFIEY
SALSDFADAL SEPLRIAKPN KISLINMDLP MVSGDRIHCM DILFAFTKRV LGESGEMDAL
KIQMEEKFMA ANPSKISYEP ITTTLRRKHE EVSATIIQRA FRRHLLQRSL KHASFLYRQQ
MGSSGVSEED APEQEGLIAY MMNENYSQRH GPPSSSSISS TSFPPSYDSV TRATSDNLQR
ARLSVKSINI ELKSMREAAP LTLGPPGLRS SAAVGAAAPA HVGKGPRDGQ AGPCVGNGPL
MSPPGSAQGP GGLGCPQVWS DNWGRPGRAG LLTPRSPAST LVPGTAHGAG IQGQLPGTCC
RTEKPHHPSL CGETGRLEFQ KGVQVKAELP SRMWADRPAP SQTRDPVSVK TVKAEALVQR
DDVAGPSEGL NGW
//
