ID S9YIN7_CAMFR Unreviewed; 879 AA.
AC S9YIN7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=26S proteasome non-ATPase regulatory subunit 3 {ECO:0000313|EMBL:EPY87216.1};
GN ORFNames=CB1_000261007 {ECO:0000313|EMBL:EPY87216.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY87216.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY87216.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SIMILARITY: Belongs to the gasdermin family.
CC {ECO:0000256|ARBA:ARBA00009279}.
CC -!- SIMILARITY: Belongs to the proteasome subunit S3 family.
CC {ECO:0000256|ARBA:ARBA00007912}.
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DR EMBL; KB016554; EPY87216.1; -; Genomic_DNA.
DR AlphaFoldDB; S9YIN7; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR GO; GO:0030234; F:enzyme regulator activity; IEA:InterPro.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-KW.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR013586; 26S_Psome_reg_C.
DR InterPro; IPR040460; Gasdermin_pore.
DR InterPro; IPR041263; Gasdermin_PUB.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10758:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3; 1.
DR PANTHER; PTHR10758; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3; 1.
DR Pfam; PF04598; Gasdermin; 1.
DR Pfam; PF17708; Gasdermin_C; 1.
DR Pfam; PF01399; PCI; 1.
DR Pfam; PF08375; Rpn3_C; 1.
DR SMART; SM00753; PAM; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Necrosis {ECO:0000256|ARBA:ARBA00022590};
KW Proteasome {ECO:0000313|EMBL:EPY87216.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684}.
FT DOMAIN 631..810
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
FT REGION 358..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..379
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..866
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 879 AA; 100022 MW; 62C27F8349126658 CRC64;
MTMFENVTRA LVRQLNPRGD LTPLDSLIDF KRFHPFCLVL RKRKSTLFWG ARYVHTDYTL
LDVLEPGSSP SDPTDSGNFG FKNMLDARVE GEVDVPKTVK VKGTANLSRN STLEVQTLSV
APTALESLHQ ERKLMVDHPF LKEMRSERMN LYVVMEVVET VQEVTLERAS KADGCFSLPI
FAPLGLQGSI NHKEAVTIPK GCILAFRVRQ LMVKGKDEWD IPCIYNDNMQ TFPLGEKPEE
EKFTREAFKD FRTLKEEVQR KTHEVEKLSP VGKSSLLCSL SKLLGKKKEL EDLEFTLEGA
LDRGHEVTLE ALPKDVLLSK EATGAILYFL GALTELSEAQ QKLLVISMEK KILPMQLKLA
KPPPGGGEQE PPPPPAPQDV EMKEEAAAGG GSTGEADGKT AATAAEHSQR ELDTVTLEDI
KEHVKQLEKA VSGKEPRFVL RALRMLPSTS RRLNHYVLYK AVHGFFTSNN ATRDFLLPFL
EEPMDTEADL QFRPRTGKAA SAPLLPEVEA YLQLLMVIFL MNSKRYKEAQ KISDDLMQKI
STQNRRALDL VAAKCYYYHA RVYEFLDKLD VVRSFLHARL RTATLRHDTD GQATLLNLLL
RNYLHYSLYD QAEKLVSKSV FPEQANNNEW ARYLYYTGRI KAIQLEYSEA RRTMTNALRK
APQHTAVGFK QTVHKLLIVV ELLLGEIPDR LQFRQPSLKR SLMPYFLLTQ AVRTGNLAKF
NQVLDQFGEK FQADGTYTLI IRLRHNVIKT GVRMISLSYS RISLADIAQK LQLDSPEDAE
FIVAKAIRDG VIEASINHEK GYVQSKEMID IYSTREPQLA FHQRISFCLD IHNMSVKAMR
FPPKSYNKDL ESAEERRERE QQDLEFAKEM AEDDDDSFP
//
