ID SAM11_MOUSE Reviewed; 542 AA.
AC Q1RNF8; Q3TU11;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=Sterile alpha motif domain-containing protein 11;
DE Short=SAM domain-containing protein 11;
DE AltName: Full=Major retinal SAM domain-containing protein;
DE Short=Mr-s;
GN Name=Samd11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, FUNCTION, TISSUE
RP SPECIFICITY, HOMODIMERIZATION, AND DEVELOPMENTAL STAGE.
RC STRAIN=ICR; TISSUE=Retina;
RX PubMed=16539743; DOI=10.1186/1471-213x-6-15;
RA Inoue T., Terada K., Furukawa A., Koike C., Tamaki Y., Araie M.,
RA Furukawa T.;
RT "Cloning and characterization of mr-s, a novel SAM domain protein,
RT predominantly expressed in retinal photoreceptor cells.";
RL BMC Dev. Biol. 6:15-15(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May play a role in photoreceptor development.
CC {ECO:0000269|PubMed:16539743}.
CC -!- SUBUNIT: Homodimer.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16539743}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in retinal photoreceptors
CC and pineal gland. {ECO:0000269|PubMed:16539743}.
CC -!- DEVELOPMENTAL STAGE: Expressed from 18 dpc in the outer aspect of
CC neuroblastic layer (NBL). {ECO:0000269|PubMed:16539743}.
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DR EMBL; AY458844; AAS67287.1; -; mRNA.
DR EMBL; AK161035; BAE36160.1; -; mRNA.
DR CCDS; CCDS89876.1; -.
DR RefSeq; XP_006538903.1; XM_006538840.3.
DR RefSeq; XP_006538904.1; XM_006538841.3.
DR RefSeq; XP_006538905.1; XM_006538842.2.
DR AlphaFoldDB; Q1RNF8; -.
DR SMR; Q1RNF8; -.
DR BioGRID; 231071; 1.
DR STRING; 10090.ENSMUSP00000136611; -.
DR iPTMnet; Q1RNF8; -.
DR PhosphoSitePlus; Q1RNF8; -.
DR PaxDb; 10090-ENSMUSP00000136611; -.
DR ProteomicsDB; 256695; -.
DR Antibodypedia; 56168; 42 antibodies from 9 providers.
DR Ensembl; ENSMUST00000217934.2; ENSMUSP00000151756.2; ENSMUSG00000096351.3.
DR Ensembl; ENSMUST00000218788.2; ENSMUSP00000151442.2; ENSMUSG00000096351.3.
DR GeneID; 231004; -.
DR UCSC; uc029vbk.1; mouse.
DR AGR; MGI:2446220; -.
DR CTD; 148398; -.
DR MGI; MGI:2446220; Samd11.
DR VEuPathDB; HostDB:ENSMUSG00000096351; -.
DR eggNOG; KOG4333; Eukaryota.
DR GeneTree; ENSGT00940000160830; -.
DR InParanoid; Q1RNF8; -.
DR OrthoDB; 2912923at2759; -.
DR BioGRID-ORCS; 231004; 1 hit in 76 CRISPR screens.
DR ChiTaRS; Samd11; mouse.
DR PRO; PR:Q1RNF8; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q1RNF8; Protein.
DR Bgee; ENSMUSG00000096351; Expressed in retinal neural layer and 65 other cell types or tissues.
DR ExpressionAtlas; Q1RNF8; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0035102; C:PRC1 complex; IDA:UniProtKB.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IMP:UniProtKB.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0042731; F:PH domain binding; IDA:MGI.
DR GO; GO:0043621; F:protein self-association; IDA:MGI.
DR GO; GO:0032093; F:SAM domain binding; IDA:MGI.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0046548; P:retinal rod cell development; IMP:UniProtKB.
DR CDD; cd09579; SAM_Samd7_11; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF67; STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 11; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..542
FT /note="Sterile alpha motif domain-containing protein 11"
FT /id="PRO_0000279501"
FT DOMAIN 404..469
FT /note="SAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT REGION 268..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..286
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 342
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q96NU1"
FT MOD_RES 499
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96NU1"
FT CONFLICT 16
FT /note="E -> Q (in Ref. 2; BAE36160)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 542 AA; 57784 MW; 6534924C1147D6A2 CRC64;
MPEHPRHCDF QRGNVEIGLG PGGDLLGKRL SCPCITSHCS SEKKARSKDP QATSLLPELE
STMAPEDHYH QLMSALSEAS SFEETQRLYH LGIPSHDLLR VRQEVATATL RGPSGLEVHL
PSSTADHRRK QGLVQRREGA VPAAATSFSE REMSQPPPLL SPQNAAHITM SSHLRPPFLG
MPTAVCQTPG FSFLPSAQAE MLARQQELLR KQSLARLEMS ELLRQKELGS VHRPLLPAPE
VALHIPEGPD ELQRRGSMLV LKHSSAPLLA LPPQGPPGPG PPIPPKESAR SRSEKGSLGV
QPSQPKETTG AGLWAQEVSE EPSKDSDGED PETAAAREGT STPSQVPAGG TRAEGRGLLS
GSTLPPPLPL GFPCGAVSPY FHTGTMGGLF TDEETTTLED VNKWTVDDVC NFVGGLSGCG
EYARVFGEQG IDGETLPLLT EEHLLNTMGL KLGPALKIRA QVAKRLGRVF YMASFPVALP
LQPPSLQAPE LSPGHQPLSP ATTTSPYEGT HLPTGQASPK QENGSGTIAL LSGAPDPSQL
LQ
//
