ID SAMC_BOVIN Reviewed; 274 AA.
AC A6QR09;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Mitochondrial S-adenosylmethionine carrier protein {ECO:0000250|UniProtKB:Q70HW3};
DE Short=SAM carrier {ECO:0000250|UniProtKB:Q70HW3};
DE AltName: Full=Solute carrier family 25 member 26;
GN Name=SLC25A26; Synonyms=SAMC {ECO:0000250|UniProtKB:Q70HW3};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Ascending colon;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial S-adenosyl-L-methionine/S-adenosyl-L-
CC homocysteine antiporter. Mediates the exchange of cytosolic S-adenosyl-
CC L-methionine, the predominant methyl-group donor for macromolecule
CC methylation processes, for mitochondrial S-adenosylhomocysteine(SAH), a
CC by-product of methylation reactions. {ECO:0000250|UniProtKB:Q70HW3}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) =
CC S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out);
CC Xref=Rhea:RHEA:75479, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789;
CC Evidence={ECO:0000250|UniProtKB:Q70HW3};
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q70HW3}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; BC150067; AAI50068.1; -; mRNA.
DR RefSeq; NP_001096767.1; NM_001103297.1.
DR AlphaFoldDB; A6QR09; -.
DR SMR; A6QR09; -.
DR STRING; 9913.ENSBTAP00000058793; -.
DR PaxDb; 9913-ENSBTAP00000050467; -.
DR Ensembl; ENSBTAT00000054584.3; ENSBTAP00000050467.3; ENSBTAG00000037972.3.
DR GeneID; 614713; -.
DR KEGG; bta:614713; -.
DR CTD; 115286; -.
DR VEuPathDB; HostDB:ENSBTAG00000037972; -.
DR VGNC; VGNC:34752; SLC25A26.
DR eggNOG; KOG0768; Eukaryota.
DR GeneTree; ENSGT00550000074950; -.
DR InParanoid; A6QR09; -.
DR OMA; IGPRTMW; -.
DR OrthoDB; 199104at2759; -.
DR Reactome; R-BTA-425393; Transport of inorganic cations/anions and amino acids/oligopeptides.
DR Proteomes; UP000009136; Chromosome 22.
DR Bgee; ENSBTAG00000037972; Expressed in oocyte and 107 other cell types or tissues.
DR ExpressionAtlas; A6QR09; baseline and differential.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0000095; F:S-adenosyl-L-methionine transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0180003; F:S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity; ISS:UniProtKB.
DR GO; GO:1990543; P:mitochondrial S-adenosyl-L-methionine transmembrane transport; ISS:UniProtKB.
DR GO; GO:0015805; P:S-adenosyl-L-methionine transport; ISS:UniProtKB.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45667; S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN; 1.
DR PANTHER; PTHR45667:SF9; S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN; 1.
DR Pfam; PF00153; Mito_carr; 4.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Antiport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Repeat; S-adenosyl-L-methionine; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..274
FT /note="Mitochondrial S-adenosylmethionine carrier protein"
FT /id="PRO_0000317586"
FT TRANSMEM 5..25
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 4..77
FT /note="Solcar 1"
FT REPEAT 86..168
FT /note="Solcar 2"
FT REPEAT 177..265
FT /note="Solcar 3"
SQ SEQUENCE 274 AA; 29409 MW; D0B86C6672135784 CRC64;
MDRPGFTASL VAGGVAGVSV DLILFPLDTI KTRLQSPQGF YKAGGFYGVY AGVPSTAIGS
FPNAAAFFVT YEYVKWILHT DSSSYLMPVT HMLAASVGEV VACLIRVPSE VVKQRAQVSA
SSGTFHIFSN ILCQEGIQGL YRGYKSTVLR EIPFSLVQFP LWESLKALWS WRQDRVVDSW
QAAVCGAFAG GFAAAVTTPL DVAKTRIMLA KAGSSTASGN ILSALHAVWR TQGLSGLFAG
VFPRMAAISL GGFIFLGVYD QTRSFLLELG RESP
//
