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Database: UniProt
Entry: SBT16_ARATH
LinkDB: SBT16_ARATH
Original site: SBT16_ARATH 
ID   SBT16_ARATH             Reviewed;         764 AA.
AC   O49607;
DT   04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   08-MAY-2019, entry version 143.
DE   RecName: Full=Subtilisin-like protease SBT1.6 {ECO:0000303|PubMed:16193095};
DE            EC=3.4.21.- {ECO:0000305};
DE   AltName: Full=Subtilase subfamily 1 member 6 {ECO:0000303|PubMed:16193095};
DE            Short=AtSBT1.6 {ECO:0000303|PubMed:16193095};
DE   AltName: Full=Subtilisin-like serine protease 2 {ECO:0000303|PubMed:12702015};
DE            Short=At-SLP2 {ECO:0000303|PubMed:12702015};
DE   Flags: Precursor;
GN   Name=SBT1.6 {ECO:0000303|PubMed:16193095};
GN   Synonyms=SLP2 {ECO:0000303|PubMed:12702015};
GN   OrderedLocusNames=At4g34980 {ECO:0000312|Araport:AT4G34980};
GN   ORFNames=M4E13.40 {ECO:0000312|EMBL:CAA17763.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G.,
RA   Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N.,
RA   Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M.,
RA   Weichselgartner M., de Simone V., Obermaier B., Mache R., Mueller M.,
RA   Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T.,
RA   Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I.,
RA   Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P.,
RA   Langham S.-A., McCullagh B., Bilham L., Robben J.,
RA   van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F.,
RA   Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E.,
RA   Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P.,
RA   Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H.,
RA   De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R.,
RA   van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S.,
RA   Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R.,
RA   Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S.,
RA   Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H.,
RA   Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A.,
RA   Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R.,
RA   Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S.,
RA   Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E.,
RA   Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A.,
RA   Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T.,
RA   Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C.,
RA   Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S.,
RA   Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K.,
RA   Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L.,
RA   Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J.,
RA   Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J.,
RA   Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D.,
RA   Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D.,
RA   Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C.,
RA   Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C.,
RA   Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R.,
RA   Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S.,
RA   Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A.,
RA   Chen E., Marra M.A., Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 402:769-777(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana
RT   reference genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA   Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA   Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA   Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA   Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA   Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA   Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA   Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA   Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA   Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA   Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA   Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   TISSUE SPECIFICITY, AND INDUCTION BY METHYL JASMONATE.
RX   PubMed=12702015; DOI=10.1034/j.1399-3054.2003.00087.x;
RA   Golldack D., Vera P., Dietz K.J.;
RT   "Expression of subtilisin-like serine proteases in Arabidopsis
RT   thaliana is cell-specific and responds to jasmonic acid and heavy
RT   metals with developmental differences.";
RL   Physiol. Plantarum 118:64-73(2003).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16193095; DOI=10.1371/journal.pcbi.0010040;
RA   Rautengarten C., Steinhauser D., Bussis D., Stintzi A., Schaller A.,
RA   Kopka J., Altmann T.;
RT   "Inferring hypotheses on functional relationships of genes: Analysis
RT   of the Arabidopsis thaliana subtilase gene family.";
RL   PLoS Comput. Biol. 1:E40-E40(2005).
CC   -!- TISSUE SPECIFICITY: Expressed in roots, leaves and flowers of
CC       mature plants. {ECO:0000269|PubMed:12702015}.
CC   -!- INDUCTION: By methyl jasmonate. {ECO:0000269|PubMed:12702015}.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000305}.
DR   EMBL; AL022023; CAA17763.1; -; Genomic_DNA.
DR   EMBL; AL161586; CAB80215.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE86443.1; -; Genomic_DNA.
DR   EMBL; AY074375; AAL67071.1; -; mRNA.
DR   EMBL; AY096357; AAM19998.1; -; mRNA.
DR   PIR; T05768; T05768.
DR   RefSeq; NP_567972.1; NM_119664.3.
DR   SMR; O49607; -.
DR   STRING; 3702.AT4G34980.1; -.
DR   MEROPS; S08.A39; -.
DR   PaxDb; O49607; -.
DR   PRIDE; O49607; -.
DR   ProMEX; O49607; -.
DR   EnsemblPlants; AT4G34980.1; AT4G34980.1; AT4G34980.
DR   GeneID; 829650; -.
DR   Gramene; AT4G34980.1; AT4G34980.1; AT4G34980.
DR   KEGG; ath:AT4G34980; -.
DR   Araport; AT4G34980; -.
DR   TAIR; locus:2131566; AT4G34980.
DR   eggNOG; ENOG410IEMN; Eukaryota.
DR   eggNOG; COG1404; LUCA.
DR   HOGENOM; HOG000238262; -.
DR   InParanoid; O49607; -.
DR   OMA; GRMFPVV; -.
DR   OrthoDB; 337164at2759; -.
DR   PhylomeDB; O49607; -.
DR   PRO; PR:O49607; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; O49607; baseline and differential.
DR   Genevisible; O49607; AT.
DR   GO; GO:0016020; C:membrane; IDA:TAIR.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0008236; F:serine-type peptidase activity; ISS:TAIR.
DR   GO; GO:0009827; P:plant-type cell wall modification; TAS:TAIR.
DR   CDD; cd04852; Peptidases_S8_3; 1.
DR   Gene3D; 3.30.70.80; -; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR034197; Peptidases_S8_3.
DR   InterPro; IPR010259; S8pro/Inhibitor_I9.
DR   InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR   InterPro; IPR041469; Subtilisin-like_FN3.
DR   Pfam; PF17766; fn3_6; 1.
DR   Pfam; PF05922; Inhibitor_I9; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Glycoprotein; Hydrolase; Protease;
KW   Reference proteome; Serine protease; Signal.
FT   SIGNAL        1     20       {ECO:0000255}.
FT   CHAIN        21    764       Subtilisin-like protease SBT1.6.
FT                                {ECO:0000255}.
FT                                /FTId=PRO_0000431965.
FT   DOMAIN       46     99       Inhibitor I9. {ECO:0000255}.
FT   DOMAIN      127    607       Peptidase S8. {ECO:0000255}.
FT   DOMAIN      377    457       PA. {ECO:0000255}.
FT   ACT_SITE    131    131       Charge relay system.
FT                                {ECO:0000255|PROSITE-ProRule:PRU10080}.
FT   ACT_SITE    205    205       Charge relay system.
FT                                {ECO:0000255|PROSITE-ProRule:PRU10081}.
FT   ACT_SITE    538    538       Charge relay system.
FT                                {ECO:0000255|PROSITE-ProRule:PRU10082}.
FT   CARBOHYD    191    191       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00498}.
FT   CARBOHYD    578    578       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00498}.
SQ   SEQUENCE   764 AA;  81046 MW;  EBB3827F26F33F50 CRC64;
     MASSTIVLLL FLSFPFISFA ASQAAKTFIF RIDGGSMPSI FPTHYHWYST EFAEESRIVH
     VYHTVFHGFS AVVTPDEADN LRNHPAVLAV FEDRRRELHT TRSPQFLGLQ NQKGLWSESD
     YGSDVIIGVF DTGIWPERRS FSDLNLGPIP KRWRGVCESG ARFSPRNCNR KIIGARFFAK
     GQQAAVIGGI NKTVEFLSPR DADGHGTHTS STAAGRHAFK ASMSGYASGV AKGVAPKARI
     AAYKVCWKDS GCLDSDILAA FDAAVRDGVD VISISIGGGD GITSPYYLDP IAIGSYGAAS
     KGIFVSSSAG NEGPNGMSVT NLAPWVTTVG ASTIDRNFPA DAILGDGHRL RGVSLYAGVP
     LNGRMFPVVY PGKSGMSSAS LCMENTLDPK QVRGKIVICD RGSSPRVAKG LVVKKAGGVG
     MILANGASNG EGLVGDAHLI PACAVGSNEG DRIKAYASSH PNPIASIDFR GTIVGIKPAP
     VIASFSGRGP NGLSPEILKP DLIAPGVNIL AAWTDAVGPT GLPSDPRKTE FNILSGTSMA
     CPHVSGAAAL LKSAHPDWSP AVIRSAMMTT TNLVDNSNRS LIDESTGKSA TPYDYGSGHL
     NLGRAMNPGL VYDITNDDYI TFLCSIGYGP KTIQVITRTP VRCPTTRKPS PGNLNYPSIT
     AVFPTNRRGL VSKTVIRTAT NVGQAEAVYR ARIESPRGVT VTVKPPRLVF TSAVKRRSYA
     VTVTVNTRNV VLGETGAVFG SVTWFDGGKH VVRSPIVVTQ MDTL
//
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