ID SCNNG_PELSI Reviewed; 669 AA.
AC K7FSQ4;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2013, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=Amiloride-sensitive sodium channel subunit gamma;
DE AltName: Full=Epithelial Na(+) channel subunit gamma;
DE Short=Gamma-ENaC;
DE AltName: Full=Gamma-NaCH;
DE AltName: Full=Nonvoltage-gated sodium channel 1 subunit gamma;
DE AltName: Full=SCNEG;
GN Name=SCNN1G;
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sodium permeable non-voltage-sensitive ion channel inhibited
CC by the diuretic amiloride. Mediates the electrodiffusion of the luminal
CC sodium (and water, which follows osmotically) through the apical
CC membrane of epithelial cells. Plays an essential role in electrolyte
CC and blood pressure homeostasis, but also in airway surface liquid
CC homeostasis, which is important for proper clearance of mucus.
CC {ECO:0000250|UniProtKB:P51170}.
CC -!- SUBUNIT: Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a
CC gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in
CC some organisms and can replace the alpha/SCNN1A subunit to form an
CC alternative channel with specific properties.
CC {ECO:0000250|UniProtKB:P51170}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000250|UniProtKB:P37091}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P37089}. Note=Apical membrane of epithelial
CC cells. {ECO:0000250|UniProtKB:P37091}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. SCNN1G subfamily. {ECO:0000305}.
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DR EMBL; AGCU01105104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01105105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01105106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006125866.1; XM_006125804.1.
DR AlphaFoldDB; K7FSQ4; -.
DR SMR; K7FSQ4; -.
DR STRING; 13735.ENSPSIP00000011064; -.
DR Ensembl; ENSPSIT00000011120.1; ENSPSIP00000011064.1; ENSPSIG00000010028.1.
DR GeneID; 102447008; -.
DR KEGG; pss:102447008; -.
DR CTD; 6340; -.
DR eggNOG; KOG4294; Eukaryota.
DR GeneTree; ENSGT00940000160352; -.
DR HOGENOM; CLU_020415_0_0_1; -.
DR OMA; SCDSRNF; -.
DR OrthoDB; 5344287at2759; -.
DR TreeFam; TF330663; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0034706; C:sodium channel complex; IEA:Ensembl.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:Ensembl.
DR GO; GO:0050699; F:WW domain binding; IEA:Ensembl.
DR GO; GO:0071468; P:cellular response to acidic pH; IEA:Ensembl.
DR GO; GO:1904045; P:cellular response to aldosterone; IEA:Ensembl.
DR GO; GO:0006883; P:intracellular sodium ion homeostasis; IEA:Ensembl.
DR GO; GO:0050891; P:multicellular organismal-level water homeostasis; IEA:Ensembl.
DR GO; GO:0098719; P:sodium ion import across plasma membrane; IEA:Ensembl.
DR GO; GO:0035725; P:sodium ion transmembrane transport; ISS:UniProtKB.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR InterPro; IPR020903; ENaC_CS.
DR NCBIfam; TIGR00859; ENaC; 1.
DR PANTHER; PTHR11690:SF19; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 3: Inferred from homology;
KW Cell membrane; Ion channel; Ion transport; Membrane; Reference proteome;
KW Sodium; Sodium channel; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..669
FT /note="Amiloride-sensitive sodium channel subunit gamma"
FT /id="PRO_0000432864"
FT TOPO_DOM 1..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P37089"
FT TRANSMEM 68..88
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..551
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:P37089"
FT TRANSMEM 552..572
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 573..669
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P37089"
FT REGION 592..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 669 AA; 76220 MW; 945D57F08FE65870 CRC64;
MAPPYHGDTR EFSMAPAKKI KAKIKKTLPV TGPQAPTVSE LMHWYCMNTN THGCRRIVVS
RGRLRKFIWI LLTLSAVGLI LWQCAELIMS YYTASVSVTV QFQKLPFPAV TICNINPYKY
SAMKEHLSEL DKETKNALET LYGFSEGKSK VRRDAADWNS TGRNMQSKLL EKIPLLKFDD
LFKKTATEIL SGHKRKIEGS AFHQGSSMVN IGEPQDVVGF QLCDPNNSSD CAVYIFSSGV
NAIQEWYKLH YMNIMAQIPL EMKVNMGYSA EDLLLTCFFD GISCDSRNFT PFHHPLYGNC
YTFNSGENGT ILTTSTGGSE YGLQVVLYVE EADYNPFLVT STGAKIIVHD QDEYPFIEDI
GTEIETAMAT SIGMHFTRSH KLSQPYSDCT ETGNDIPVAN LYNKSYSLQI CLHSCFQRAM
VDTCGCAQYA QPLPPGAEYC NYKKYPNWMY CYYKLHEKFV KEQLGCQQIC KESCSFKEWT
LTTSLAQWPS SVSEDWMLRV LSWDKRQKIN KMLNKTDLAN LVVFYKDLNE RFISENPANN
LVILLSNFGG QLGLWMSCSM VCVIEIIEVF FIDSFSIVMR RRWQKMKKWW NDRKAPRPQE
PPQVNAPAKE GHDNPVCTDE DLPTFNTALR LPLPQENHMP RTPPPNYSTL QLNAAFTDQL
PDTLEGRSH
//
