ID SDA1_DICDI Reviewed; 756 AA.
AC Q55DE2;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 84.
DE RecName: Full=Protein SDA1 homolog;
DE AltName: Full=SDA1 domain-containing protein 1 homolog;
GN Name=sdad1; ORFNames=DDB_G0269688;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Required for 60S pre-ribosomal subunits export to the
CC cytoplasm. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SDA1 family. {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72194.1; -; Genomic_DNA.
DR RefSeq; XP_646189.1; XM_641097.1.
DR AlphaFoldDB; Q55DE2; -.
DR SMR; Q55DE2; -.
DR STRING; 44689.Q55DE2; -.
DR PaxDb; 44689-DDB0266533; -.
DR EnsemblProtists; EAL72194; EAL72194; DDB_G0269688.
DR GeneID; 8617142; -.
DR KEGG; ddi:DDB_G0269688; -.
DR dictyBase; DDB_G0269688; sdad1.
DR eggNOG; KOG2229; Eukaryota.
DR HOGENOM; CLU_009161_3_1_1; -.
DR InParanoid; Q55DE2; -.
DR OMA; AMYKTYK; -.
DR PhylomeDB; Q55DE2; -.
DR PRO; PR:Q55DE2; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR GO; GO:0000055; P:ribosomal large subunit export from nucleus; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027312; Sda1.
DR InterPro; IPR048292; SDA1_C.
DR InterPro; IPR007949; SDA1_MD.
DR InterPro; IPR012977; SDA1_N.
DR PANTHER; PTHR12730; HSDA/SDA1-RELATED; 1.
DR PANTHER; PTHR12730:SF0; PROTEIN SDA1 HOMOLOG; 1.
DR Pfam; PF21638; SDA1_C; 1.
DR Pfam; PF05285; SDA1_dom; 1.
DR Pfam; PF08158; SDA1_HEAT; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Protein transport; Reference proteome;
KW Ribosome biogenesis; Transport.
FT CHAIN 1..756
FT /note="Protein SDA1 homolog"
FT /id="PRO_0000328429"
FT REGION 494..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 227..282
FT /evidence="ECO:0000255"
FT COMPBIAS 495..518
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..594
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..615
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 756 AA; 88003 MW; 8FC43FD4E0977FFA CRC64;
MGTRILDLLQ LQNLTKRDPS AYKEEFLLQY QHYLTQLQIF QLKPTKEFKH FSQLVSYLSH
VCVCYPKELS EFPKQISDLL ENNCNNLEPE LRRILAKSLI LMRNRNLLPQ IQMLSLFFKL
FRVHDKPLRS LLYSHIVADI KNTNLKQKNQ KLNRTLQNFM FTMMNDDSEI ASKMSLKVMI
ELFRKKIWHD TKTVNVISNG VFSKNSKILI TTLNFFLHID NPDKPDEEEE DEAVKEKRAK
DNFRKKSLAH RVGKKTKGRI TRLAKSKVDL KKAKQEEDNK LQPNFPAIEL IHDPQGYCDK
LFNVLVKTTE KFETRIMIMN FISRLIYVHK LMVYNFYPFL QKYLQPHQKN ITYLLAVLAQ
SCHELVDPDV LKPLVMTIAK YFVNDGCGSD VIAIGLNTIR SICSRCPLAI DTVLLADLIQ
YREKKEKGVA MASKSLLQFF KDNYPSMLPK KERGKNKTDI GLLAFGHQKV SQGIDGLDLL
MDEELNARLD AIEAGEEFES DDDSDSDSDD EGWEDVNTTT ADDDNNSEWV SDDDDEEGEE
DEEVEDEEDE EEVDEEELED DEEGDWESGE EIEGDDDDDE EWEEVEEEVE EEEEEEIKPT
KKKSQQKEKV EVLRTDDIKV LTDEELIRIR KLRILKEARE NNKQYEDMDQ DDDENGENVH
GLIRPEDLQG AHKKKKEEKL ERIARAKEGR DGGYGSKASR RDKTGKSTTN EYKAKVTKPF
VLTLKTKKVR GKSLKSFRDK QIGQREHSAR QKRGRH
//
