ID SET4_YEAST Reviewed; 560 AA.
AC P42948; D6VW79;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 27-MAR-2024, entry version 154.
DE RecName: Full=SET domain-containing protein 4;
GN Name=SET4; OrderedLocusNames=YJL105W; ORFNames=J0819;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=7483851; DOI=10.1002/yea.320110909;
RA Rasmussen S.W.;
RT "A 37.5 kb region of yeast chromosome X includes the SME1, MEF2, GSH1 and
RT CSD3 genes, a TCP-1-related gene, an open reading frame similar to the
RT DAL80 gene, and a tRNA(Arg).";
RL Yeast 11:873-883(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- FUNCTION: Putative chromatin regulator.
CC -!- SIMILARITY: Belongs to the SET3 family. {ECO:0000305}.
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DR EMBL; X85021; CAA59389.1; -; Genomic_DNA.
DR EMBL; Z49380; CAA89400.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08695.1; -; Genomic_DNA.
DR PIR; S53382; S53382.
DR RefSeq; NP_012430.1; NM_001181538.1.
DR AlphaFoldDB; P42948; -.
DR SMR; P42948; -.
DR BioGRID; 33651; 106.
DR MINT; P42948; -.
DR STRING; 4932.YJL105W; -.
DR CarbonylDB; P42948; -.
DR PaxDb; 4932-YJL105W; -.
DR PeptideAtlas; P42948; -.
DR EnsemblFungi; YJL105W_mRNA; YJL105W; YJL105W.
DR GeneID; 853339; -.
DR KEGG; sce:YJL105W; -.
DR AGR; SGD:S000003641; -.
DR SGD; S000003641; SET4.
DR VEuPathDB; FungiDB:YJL105W; -.
DR eggNOG; KOG1844; Eukaryota.
DR GeneTree; ENSGT00940000168747; -.
DR HOGENOM; CLU_017047_1_0_1; -.
DR InParanoid; P42948; -.
DR OMA; NTIMHNC; -.
DR OrthoDB; 124870at2759; -.
DR BioCyc; YEAST:G3O-31559-MONOMER; -.
DR BioGRID-ORCS; 853339; 0 hits in 10 CRISPR screens.
DR PRO; PR:P42948; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P42948; Protein.
DR GO; GO:0070210; C:Rpd3L-Expanded complex; IBA:GO_Central.
DR GO; GO:0034967; C:Set3 complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035064; F:methylated histone binding; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd19183; SET_SpSET3-like; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR044435; Set3/4_SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46462; UPSET, ISOFORM A; 1.
DR PANTHER; PTHR46462:SF3; UPSET, ISOFORM A; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Chromatin regulator; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..560
FT /note="SET domain-containing protein 4"
FT /id="PRO_0000097697"
FT DOMAIN 346..475
FT /note="SET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT ZN_FING 160..210
FT /note="PHD-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 560 AA; 63856 MW; 9A7BAECE97318AFA CRC64;
MTSPESLSSR HIRQGRTYTT TDKVISRSSS YSSNSSMSKD YGDHTPLSVS SAASETLPSP
QYMPIRTFNT MPTAGPTPLH LFQNDRGIFN HHSSSGSSKT ASTNKRGIAA AVALATAATI
PFPLKKQNQD DNSKVSVTHN ESSKENKITP SMRAEDNKPK NGCICGSSDS KDELFIQCNK
CKTWQHKLCY AFKKSDPIKR DFVCKRCDSD TKVQVNQVKP MIFPRKMGDE RLFQFSSIVT
TSASNTNQHQ QSVNNIEEQP KKRQLHYTAP TTENSNSIRK KLRQEKLVVS SHFLKPLLNE
VSSSNDTEFK AITISEYKDK YVKMFIDNHY DDDWVVCSNW ESSRSADIEV RKSSNERDFG
VFAADSCVKG ELIQEYLGKI DFQKNYQTDP NNDYRLMGTT KPKVLFHPHW PLYIDSRETG
GLTRYIRRSC EPNVELVTVR PLDEKPRGDN DCRVKFVLRA IRDIRKGEEI SVEWQWDLRN
PIWEIINASK DLDSLPDPDK FWLMGSIKTI LTNCDCACGY LGHNCPITKI KNFSEEFMRN
TKESLSNKSY FNTIMHNCKP
//
